Erosa (Erythromycin)|Therapeutic Class: Anti-diarrhoeal Antimicrobial, Macrolide Antibiotic
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Erosa (Erythromycin) belongs to the macrolide group of antibiotics. It acts by interfering with bacterial ribosomal protein synthesis, exerting either a bacteriostatic or bactericidal effect depending on concentration and organism susceptibility.
Erythromycin inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome, preventing translocation during translation. It does not bind to mammalian ribosomes (80S), ensuring selective antibacterial activity.
Upper Respiratory Tract Infections:
Lower Respiratory Tract Infections:
Ear Infections:
Eye Infections:
Skin and Soft Tissue Infections:
Gastrointestinal Tract Infections:
Prophylaxis:
Other Infections:
Nausea, vomiting, abdominal pain, or diarrhea
Rarely, allergic reactions (including anaphylaxis)
Adults and Children (over 8 years):
Mild to moderate infections: 250–500 mg every 6 hours.
Severe infections: Up to 4 g daily in divided doses.
Elderly:
No specific dosage adjustment required. May be given twice or thrice daily, depending on total daily requirement.
Children (2–8 years):
250 mg every 6 hours or 30–50 mg/kg/day in 4 divided doses.
Infants and Children (up to 2 years):
30–50 mg/kg/day in divided doses.
Concomitant use with theophylline may increase serum theophylline levels and risk of toxicity.
→ Action: Reduce theophylline dosage if necessary.
Known hypersensitivity to erythromycin or other macrolide antibiotics.
Studies show no evidence of teratogenicity or fetal toxicity in humans.
However, as erythromycin crosses the placenta and is excreted in breast milk, caution is advised when prescribing to pregnant or lactating women.
Use with caution in patients with hepatic impairment, as the drug is primarily excreted via bile.
Regular monitoring is advised during prolonged therapy.
Store below 25°C, protected from light and moisture.
Keep out of the reach of children.
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