Flagyl 400mg 10pcs

Indications of Flagyl 400

The following illnesses are appropriate for treatment with Flagyl 400:

• the protection against anaerobic bacteria-caused postoperative infections.
• the management of anaerobe-caused post-operative wound infections, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, and septicemia.
• urogenital trichomoniasis therapy.
• Bacterial vaginosis
• Amoebiasis in all its manifestations.
• acute gingivitis with ulcers.
• Pressure sores and leg ulcers that are anaerobically infected.
• bacterial anaerobic acute dental infections.
• Colitis with pseudomembranous and antibiotics.

Pharmacology

The antibacterial drug Flagyl 400, which is a member of the imidazole class, is employed as an antiprotozoal agent. Metronidazole's 5-nitro group is metabolized less by anaerobes. Studies have shown that the reduced form of this medication interacts with DNA and has a bactericidal effect.

Dosage & Administration of Flagyl 400

Suspension and Tablet:

Trichomoniasis (Adults and Children Over the Age of 10)-

For 7 days, take 200 mg tid or 400 mg bid.

For two days, take 800 mg in the morning and 1-2 gm at night.

2 gm in one dose for one day

Children's Trichomoniasis-

Children aged 7 to 10 years: 100 mg bid

Children aged 3 to 7 years: 100 mg bid

Children aged 1-3 years: 50 mg bid

Intestinal amoebiasis (Adults & Children over 10 yrs)- 

For 5 days, take 800 mg bid.

Amoebiasis of the intestine (Children)-

400 mg bid for children aged 7 to 10 years.

Children aged 3 to 7 years: 200 mg bid

Children aged 1-3 years: 200 mg twice daily

Extra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs)-

400-800 mg tid for 5-10 days

Extra-intestinal & Asymptomatic amoebiasis (Children)-

Children 7-10 yrs: 200-400 mg tid

Children 3-7 yrs: 100-200 mg qid

Children 1-3 yrs: 100-200 mg tid

Giardiasis (Adults & Children over 10 yrs)-

2 gm once daily for 3 days

Giardiasis (Children)-

Children 7-10 yrs: 1 gm once daily

Children 3-7 yrs: 600-800 mg once daily

Children 1-3 yrs: 500 mg once daily

Acute ulcerative gingivitis (Adults & Children over 10 yrs)-

200 mg tid for 3 days

Acute ulcerative gingivitis (Children)-

Children 7-10 yrs: 100 mg tid

Children 3-7 yrs: 100 mg bid

Children 1-3 yrs: 50 mg tid

Acute dental infections (Adults & Children over 10 yrs)-

200 mg tid for 3-7 days

Bacterial Vaginosis (Adults & Children over 10 yrs)-

400 mg bid for 7 days

2 gm as a single dose for 1 day

Leg ulcers and pressure sores (Adults & Children over 10 yrs)-

400 mg tid for 7 days

Anaerobic infections (Adults & Children over 10 yrs)-

800 mg initially and then 400 mg tid for 7 days

Anaerobic infections (Children)-

Children 1-10 yrs: 7.5 mg/kg tid

Surgical prophylaxis (Adults & Children over 10 yrs)-

400 mg tid started 24  hours before  surgery for 1 day

Surgical prophylaxis (Children)-

Children 1-10 yrs: 7.5 mg/kg tid

Vaginal Gel:

As an antiprotozoal agent, the antibacterial medication Flagyl 400, which belongs to the imidazole class, is used. Anaerobes metabolize the 5-nitro group of metronidazole less efficiently. According to studies, this medication's reduced version interacts with DNA and kills bacteria.

Suppository:

Anaerobic Infections-

Adults: 1 g every 8 hours for three days, followed by 1 g every 12 hours.

Children aged 5 to 10 years: 500 mg every 8 hours for three days, then every 12 hours; adults aged 10 and up: 500 mg every 12 hours.

Surgical Precautions-

Adults: 1 g 2 hours before surgery; up to 3 additional 1 g doses every 8 hours for high-risk procedures.

Children 5-10 years old: 500 mg 2 hours before surgery; up to 3 additional 500 mg doses every 8 hours for high-risk procedures.

IV Infusion:

Metronidazole intravenous infusion requires no dilution and should not be mixed with any other drugs prior to administration.

Adults and children over the age of 12 should infuse 500 mg 8 hourly at a rate of 5 ml/minute, with a 24-hour maximum of 4 g. Most patients require only 7 days of treatment, but this can be extended in cases where reinfection is likely. Administration shortly before surgery should be followed by 8-hourly doses for the next 24 hours for surgical prophylaxis.

Children under the age of 12: 7.5 mg/kg body weight/day, administered every 8 hours at a rate of 5 ml/minute.

Interaction of Flagyl 400

Concurrent use of disulfiram may result in psychotic symptoms. Oral anticoagulants' effect may be enhanced. Lithium toxicity may be increased. 5-fluorouracil toxicity may be increased if renal clearance is reduced. Cyclosporin serum levels may rise. Busulfan plasma levels may rise, resulting in severe busulfan toxicity. Increased metabolism with phenobarbital and phenytoin results in lower serum concentrations.

Contraindications

Patients having a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives should avoid taking it. 

Side Effects of Flagyl 400

During treatment, metallic taste, nausea, vomiting, diarrhea, sleepiness, and rashes may occur.

Pregnancy & Lactation

US FDA Pregnancy Category of Metronidazole is B. There are, be that as it may, no satisfactory and well-controlled considerations in pregnant ladies. Since creature propagation ponders are not continuously prescient of human reaction, this medication ought to be utilized amid pregnancy as it were in the event that clearly required. Metronidazole has appeared to be excreted in the human drain. So, caution ought to be worked out when Metronidazole is managed by a nursing woman.

Precautions & Warnings

If abnormal neurologic symptoms occur in patients with CNS diseases, discontinue IV therapy. Seizure disorder in the past. If there is evidence or a history of blood dyscrasias, total and differential leukocyte counts should be performed before and after treatment. Severe hepatic impairment; keep an eye on plasma levels. Edema susceptibility (inj contains sodium). Use for an extended period of time may result in fungal or bacterial superinfection. Human milk excreted; not recommended.

Metronidazole should be administered with caution to patients with hepatic encephalopathy.

Patients should be warned that metronidazole may darken the urine.

Storage Conditions

Keep it below 30°C. Protect yourself from the sun. Medicines should be kept out of the reach of youngsters. Do not use it after the expiration date.