Linez 600mg 6pcs Tablet

✔️ Side Effects of Linez 600

• headache
• Dizziness
• Metallic taste in the mouth
• Diarrhea
• Nausea
• Vomiting,
• Localized or general stomach pain,
• Constipation
• Indigestion
• Difficulty in sleeping
• Localized pain
• Increased blood pressure

✔️ Dosage and Administration of Linezolid

Route of Administration:

• Tablets: Oral, with or without food.
• IV Infusion: Administer via intravenous infusion over 30 to 120 minutes.

Recommended Dosage Table:

Neonates (<7 Days Old):

• Pre-term neonates (<34 weeks gestational age): Start with 10 mg/kg every 12 hours.
  • Consider increasing to 10 mg/kg every 8 hours for suboptimal clinical response.
• By 7 days of life, all neonates should receive 10 mg/kg every 8 hours.

Note: No dose adjustment is required when switching from IV to oral administration.

✔️ Intravenous Administration Instructions:

• Inspect the IV solution for particulate matter before use.
• The solution may appear yellow; this color intensifies over time without affecting potency.
• Do not use vials in series connections or introduce additives into the solution.
• Discard any unused portion after a single use.

✔️ Pediatric Use:

• Linezolid dosing in children is specified in the dosage table above.
• Not recommended for the empiric treatment of central nervous system infections in pediatric patients.

✔️ Hepatic Impairment:

• Mild-to-Moderate Impairment: No dose adjustment is required.
• Severe Impairment: Pharmacokinetics not evaluated; caution is advised.

✔️ Interactions of Linezolid

Drug Interaction with Medications:

• Monoamine Oxidase Inhibition: Linezolid is a reversible, nonselective inhibitor of monoamine oxidase (MAO), making it prone to interactions with adrenergic and serotonergic agents.
• Adrenergic Agents: This may cause a reversible increase in pressure response to indirect-acting sympathomimetics, vasopressors, or dopaminergic agents.
• Serotonergic Agents: Should not be administered to patients taking serotonin reuptake inhibitors, tricyclic antidepressants, serotonin 5-HT1 receptor agonists (e.g., triptans), meperidine, or buspirone unless patients are closely monitored for signs of serotonin syndrome.
• Carcinoid Syndrome Patients: Avoid use unless under careful observation.

Drug Interaction with Food and Other Substances:

• Patients should avoid foods and beverages with high tyramine content (e.g., aged cheese, smoked meats, fermented products, some beers, and soy products) while taking Linezolid to prevent hypertensive crises.

✔️ Contraindications:

Contraindicated in patients with a known hypersensitivity to Linezolid or its components.

Monoamine Oxidase Inhibitors (MAOIs): Should not be used in patients taking medicinal products that inhibit monoamine oxidases A or B (e.g., Phenelzine, Isocarboxazid) or within two weeks of discontinuing these agents.

Pre-existing Conditions:

• Uncontrolled hypertension
• Pheochromocytoma
• Thyrotoxicosis
• Carcinoid syndrome

Concurrent Medications: Avoid use with:

• Sympathomimetic agents: E.g., Pseudoephedrine
• Vasopressive agents: E.g., Epinephrine, Norepinephrine
• Dopaminergic agents: E.g., Dopamine, Dobutamine
• Serotonergic agents: Serotonin reuptake inhibitors, tricyclic antidepressants, serotonin 5-HT1 receptor agonists (e.g., triptans), meperidine, or buspirone.

✔️ Pregnancy & Lactation

Pregnancy:
Available data on the use of Linezolid during pregnancy have not shown a clear risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. However, Linezolid should only be used during pregnancy if the potential benefits outweigh the risks to the fetus.

Lactation:
Linezolid is present in breast milk. The decision to breastfeed should consider the benefits of breastfeeding for the child and the clinical need for Linezolid for the mother, along with any potential risks. Lactating women should monitor their infants for diarrhea and vomiting.

✔️ Precautions & Warnings:

Complete Blood Counts (CBC):
Weekly monitoring of complete blood counts is recommended for patients receiving Linezolid, especially if:

• Treatment lasts longer than two weeks
• The patient has pre-existing myelosuppression
• The patient is on other bone marrow-suppressing medications
• The patient has chronic infections or previous/concomitant antibiotic therapy.

Vision Changes:
If patients experience symptoms of visual impairment (e.g., changes in visual acuity, color vision, blurred vision, or visual field defects), an ophthalmic evaluation is recommended.

Infection Site Concerns:
Linezolid is not approved for treating catheter-related bloodstream infections or catheter-site infections.

Clostridium Difficile-Associated Diarrhea (CDAD):
CDAD can occur up to two months after antibiotic treatment. If suspected or confirmed, antibiotic therapy not directed against C. difficile should be stopped.

Hypertension & Related Conditions:
Linezolid should be used with caution in patients with uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, or those taking sympathomimetic agents, vasopressors, or dopaminergic agents. Blood pressure should be monitored regularly.

Gastrointestinal & Metabolic Issues:
If patients develop recurrent nausea or vomiting, unexplained acidosis, or low bicarbonate levels, they should receive immediate medical evaluation.

Hypoglycemia Management:
If hypoglycemia occurs, a dose adjustment of insulin or oral hypoglycemic agents may be required, or the medication may need to be discontinued.

✔️ Storage:

Store in a cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.