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Manufacturer/Distributor: Square Pharmaceuticals Ltd. Generic Name: Amoxicillin Trihydrate 500mg
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✅ Description:
Amoxicillin is indicated in the treatment of infections due to susceptible ß-lactamase negative strains of microorganisms. These infections include
Ear, nose and throat infections (i.e. otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis)
Lower respiratory tract infections (i.e. pneumonia, acute and chronic bronchitis lung abscess, empyema, bronchiectasis)
Skin and soft tissue infections (i.e. cellulitis, carbuncles, furunculi's, infected wounds, abscess)
Genito-urinary tract infections (i.e. pyelonephritis, cystitis and urethritis)
Venereal disease (i.e. acute uncomplicated gonorrhoeic)
In dental abscess, it is used as short-term therapy.
It is also indicated in combination with Clarithromycin and Lansoprazole (as triple therapy), for the treatment of patients with H. pylori infection and duodenal ulcer disease and to reduce the risk of duodenal ulcer recurrence.
Dosage
Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.
Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.
Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
Pneumonia: Recommended dose is 500-1000 mg three times daily.
Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
In renal impairment: it may be necessary to reduce the total daily dosage.
Side Effects
Side effects are mild and transient in nature. This may include diarrhoea, indigestion or occasionally rash. Pseudo-membranous colitis has been reported rarely.
Pregnancy & Lactation
US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother.
Precautions & Warnings
The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxicillin should be discontinued and appropriate therapy should be instituted.
Reconstitution
Amoxycillin 500 mg Injection:
Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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