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Eye Drops,Generic: Moxifloxacin 0.5% Eye prep.Healthcare Pharmaceuticals Ltd.
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✅ Description:
Indications
The ophthalmic solution is used to treat bacterial conjunctivitis caused by sensitive strains of the bacteria listed below:
Corynebacterium species, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus warneri, Streptococcus pneumoniae, Streptococcus viridans group, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococc
Acinetobacterlwoffii, Haemophilusinfluenzae, and Haemophilus parainfluenzae are Gram-negative aerobic bacteria.
Chlamydia trachomatis is an example of other bacteria.
Pharmacology
Moxifloxacin's antibacterial activity is due to the inhibition of topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is a necessary enzyme for the replication, transcription, and repair of bacterial DNA. Topoisomerase IV is an enzyme that is involved in chromosomal DNA partitioning during bacterial cell division.
Dosage & Administration
Eye Drops: One drop in the affected eye 3 times per day for 7 days.
Eye Ointment: It should be applied thinly and evenly to the affected eye three times a day for the first two days and for the next five days apply two times a day or as advised by the registered physician.
Interaction
Moxifloxacin Hydrochloride ophthalmic solution has not been subjected to drug-drug interaction investigations. Moxifloxacin does not inhibit CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2, according to in vitro investigations, indicating that it is unlikely to affect the pharmacokinetics of medicines metabolized by these cytochrome P450 isozymes.
Contraindications
Moxifloxacin Patients having a history of hypersensitivity to Moxifloxacin, other quinolones, or any of the components in this drug should not use the hydrochloride ophthalmic solution.
Side Effects
Conjunctivitis, reduced visual acuity, dry eye, keratitis, ocular discomfort, ocular hyperemia, ocular pain, ocular pruritus, subconjunctival hemorrhage, and tears were the most commonly reported ocular side effects. Approximately 1-6 percent of participants experienced these complications. Fever, increased cough, infection, otitis media, pharyngitis, rash, and rhinitis were among the non-ocular side effects recorded at an incidence of 1-4 percent.
Pregnancy & Lactation
Because no sufficient and well-controlled trials in pregnant women have been conducted, Moxifloxacin Hydrochloride ophthalmic solution should only be used during pregnancy if the possible benefit outweighs the risk to the fetus. Although moxifloxacin has not been detected in human milk, it is thought to be excreted in it. When administering Moxifloxacin hydrochloride ophthalmic solution to a nursing mother, use caution.
Precautions & Warnings
Prolonged use of anti-infectives, like other antibiotics, can lead to the proliferation of non-susceptible organisms, such as fungi. If superinfection arises, stop using it and seek alternate treatment. When clinical judgment demands, the patient should be evaluated under magnification, such as slit lamp biomicroscopy, and fluorescein staining, if applicable. If a patient has signs and symptoms of bacterial conjunctivitis, they should not wear contact lenses.
Storage Conditions
Keep it below 25°C. Do not allow yourself to become frozen. Store in a cold, dry, and light-protected location. Keep out of children's reach. Do not touch the dropper tip to any surface, as this could contaminate the mixture. After one month from the date of initial opening, do not use.
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