Odazyth Powder For Suspension

✔️ Mechanism of Action:

• Binds to the 50S ribosomal subunit of bacteria, inhibiting protein synthesis.
• Does not affect nucleic acid synthesis.

Active against:

• Gram-positive bacteria: Staphylococcus aureus, Streptococcus agalactiae, S. pneumoniae, S. pyogenes, Viridans streptococci, Streptococci groups C, F, G
• Gram-negative bacteria: Haemophilus influenzae, H. ducreyi, Moraxella catarrhalis, Neisseria gonorrhoeae, Bordetella pertussis, Legionella pneumophila
• Other microorganisms: Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae
• Anaerobes: Peptostreptococcus species, Prevotella bivia

Note: Activity is not affected by β-lactamase production.

✔️ Dosage & Administration

Oral (Adults):

500 mg once daily for 3 days OR

500 mg on day 1, then 250 mg daily for 2–4 days

For STIs (Chlamydia):

1 g single dose OR 500 mg day 1 + 250 mg daily for 2 days

Oral (Children):

6 months: 10 mg/kg once daily for 3 days

15–25 kg: 200 mg daily

26–35 kg: 300 mg daily

36–45 kg: 400 mg daily

Typhoid fever: 500 mg once daily for 7–10 days

IV Injection (Adults):

Community-acquired pneumonia: 500 mg IV once daily for ≥2 days, then switch to oral 500 mg daily to complete 7–10 days

Pelvic inflammatory disease: 500 mg IV once daily for 1–2 days, then switch to oral 250 mg daily for 7 days

Use in children <16 years for IV therapy is not established

Oral Administration Notes:

Take at least 1 hour before or 2 hours after meals

Suspension Reconstitution:

Shake bottle to loosen powder

Add boiled and cooled water to the mark

Shake until fully dissolved

✔️ Interactions

Antacids: Take at least 1 hour before or 2 hours after

Cyclosporin: Monitor levels due to potential interaction

Digoxin: Monitor levels; may impair metabolism

Ergot derivatives: Avoid co-administration

Warfarin: Can be co-administered; monitor prothrombin time

Other drugs (carbamazepine, methylprednisolone, terfenadine, theophylline, terfenadine): Generally safe, but monitor as needed

✔️ Contraindications:

Hypersensitivity to azithromycin or other macrolides

Co-administration with ergot derivatives

Patients with hepatic disease

✔️ Side Effects

Common: Nausea, vomiting, abdominal discomfort, diarrhea, flatulence, loose stools

Allergic reactions: Rash, photosensitivity

Rare: Serious hypersensitivity, reversible liver enzyme elevation, cholestatic jaundice, mild transient neutrophil reduction, reversible hearing impairment at high doses

✔️ Pregnancy & Lactation

Category B: No evidence of fetal harm in animal studies; use only if necessary in humans

Unknown if excreted in breast milk; exercise caution

✔️ Precautions & Warnings

Rare serious allergic reactions including angioneurotic edema and anaphylaxis

Avoid in hepatic impairment

Use caution in renal impairment (creatinine clearance <40 mL/min)

✔️ Storage:

Keep in a dry, cool place away from light and heat

Keep out of reach of children