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Omastin Powder For Suspension 35ml
Generic Name: Fluconazole 50mg
Manufacturer/Distributor: Beximco Pharmaceuticals Ltd.
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✅ Description:
Indications
Vaginal candidiasis, oropharyngeal & esophageal candidiasis and cryptococcal meningitis are all treated with fluconazole. It can also be used to treat candida infections in the urinary tract, peritonitis, and systemic candida infections (including candidemia, disseminated candidiasis, and pneumonia).
Pharmacology
Fluconazole is a triazole antifungal that is used to treat fungal infections. It's a strong inhibitor of cytochrome P-450-dependent enzymes in fungi. The ergosterol synthesis is carried out by the Cytochrome P-450 enzyme system, which is an important component of the fungal cell membrane.
Dosage & Administration
Adult (oral)-
Vaginal candidiasis: 150 mg as a single dose.
Oropharyngeal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Clinical evidence of this infection generally resolves within several days, but treatment should be continued for at least 2 weeks to decrease the likelihood of relapse.
Esophageal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Doses up to 400 mg/day may be used. Patients should be treated for a minimum of three weeks and for at least two weeks following the resolution of symptoms.
Systemic candida infections: Optimal therapeutic dosage and duration of therapy have not been established. Sometimes, doses of up to 400 mg daily have been used.
Urinary tract infections caused by candida and peritonitis: 50-200 mg daily have been used.
Cryptococcal meningitis: 400 mg on the first day, followed by 200 mg once daily.
Prophylaxis in patients undergoing bone marrow transplantation: 400 mg once daily.
Child (oral):
Doses of 3-6 mg/kg daily have been used. Doses up to 12 mg/kg are recommended.
Intravenous-
Adult: Invasive candidal infections including candidaemia and disseminated candidiasis and cryptococcal infections including meningitis, by IV, 400 mg initially then 200 mg daily, increased if necessary to 400 mg daily, treatment continued according to response (at least 6-8 weeks for cryptococcal meningitis)
Child: 6-12 mg/kg daily (every 72 hours in neonate up to 2 weeks old, every 48 hours in neonate 2-4 weeks old); maximum 400 mg daily. Prevention of relapse of cryptococcal meningitis, by IV, 100-200 mg daily.
Interaction
Concomitant use of cyclosporin or phenytoin with Fluconazole increases the plasma level of cyclosporin or phenytoin. Concomitant use of Fluconazole & warfarin prolongs the prothrombin time. Rifampicin level is decreased when used with Fluconazole.
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.
Side Effects
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.
Pregnancy & Lactation
US FDA Pregnancy category of Fluconazole is C. So, Fluconazole should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Precautions & Warnings
Fluconazole should be administered with caution to patients having proarrhythmic conditions.
Storage Conditions
Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.
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