Pronil 500mg

Pronil is an antibiotic medicine that helps your body fight infections caused by bacteria and parasites. It is used to treat infections of the liver, stomach, intestines, vagina, brain, heart, lungs, and skin. Pronil is also used in the treatment of dental infections, leg ulcers and pressure sores. This medicine may be taken with or without food. However, it should be taken at the same time each day to get the most benefit. The amount you are advised will depend on what you are being treated for and how bad it is, but you should take this antibiotic exactly as prescribed by your doctor. Your symptoms may get better after a short time but do not stop taking it until you have finished a full course of treatment, even if you feel well. If you stop taking it early, some bacteria may survive, and the infection may come back. Do not drink any alcohol while taking this medicine and for some days after stopping it. Otherwise, you may get unpleasant side effects like nausea, vomiting and stomach pain. The most common side effects of this medicine are headache, vomiting, nausea, and vomiting. These are usually mild but let your doctor know if they bother you or last more than a few days. You can try using sugarless candies or lozenges to overcome any dryness or metallic taste in the mouth. Before using this medicine, inform your doctor if you are allergic to any medicine or have any kidney or liver problems or any disease of the nervous system. Your doctor may change the dose or prescribe a different medicine. This medicine should not be taken if you are pregnant or breastfeeding unless it is absolutely necessary and prescribed by your doctor.

Uses of Pronil

• Bacterial & parasitic infections

Side effects of Pronil

Common

• Headache
• Nausea
• Vomiting
• Abdominal pain
• Diarrhea
• Vaginal itching
• Vaginal yeast infection

How to use Pronil

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pronil is to be taken with food.

How Pronil works

Pronil is an antibiotic. It kills the bacteria and other microorganisms that cause infections by damaging their DNA.

What if you forget to take Pronil?

If you miss a dose of Pronil, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

• Always take the complete course of treatment, as advised by your doctor, even if you feel better.
• It may cause side effects like nausea, stomach upset, and a metallic taste in the mouth.
• Pronil used in a high dose or for a prolonged time increases the risk of side effects such as nerve damage. Take it only as prescribed by your doctor.
• Do not drink alcohol during or for 2-3 days after treatment with this medicine. You may develop nausea, vomiting, flushing and headache.
• Inform your doctor if you have liver disease. Your dose may need to be adjusted in severe liver disease.
• Pronil treats infections caused by bacteria and parasites.
• It may also be used to prevent infections following surgery.

Brief Description

Indication

Giardiasis, Amoebiasis, Trichomoniasis

Adult Dose

Oral Trichomoniasis; Amoebiasis; Giardiasis Adult: 2 g as a single dose. Severe invasive amoebiasis Adult: 1.5 g daily as single or in divided doses for 5 days.

Child Dose

Oral Trichomoniasis; Amoebiasis; Giardiasis Child: 30 mg/kg as a single dose. Severe invasive amoebiasis Child: 30 mg/kg daily for 5 days.

Contraindication

Hypersensitivity; pregnancy (1st trimester) and lactation.

Mode of Action

Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage.

Precaution

Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders.

Side Effect

Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances.

Interaction

Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life. Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage.