Rozith Suspension 15ml - ePharma
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Rozith Suspension 15ml

Generic: Azithromycin

Type: Suspension

Pack Size: 15ml

Generic Name: Azithromycin 200/5mg/ml

Manufacturer/Distributor: Healthcare Pharmaceuticals Limited


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Discount Price: ৳ 89.3
MRP: ৳ 95 6% Off

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✅ Description:

Indications of Rozith 15 ml Powder For Suspension

Rozith is an antibiotic used to treat different kinds of bacterial infections in both adult's and children's eyes, skin, lungs, ears, nose, and throat. Additionally, it works well against typhoid fever and a few STDs, including gonorrhea. Rozith is a broad-spectrum antibiotic that works well to eliminate various gram-positive and gram-negative bacteria as well as other microorganisms.

Pharmacology of Rozith 15 ml Powder For Suspension

Since azithromycin is acid-stable, it can be taken orally without a stomach acid protectant. It is quickly absorbed, and an empty stomach allows for greater absorption. The oral dosage form has a 2.1 to 3.2 hour time to maximum concentration in adults. The reason azithromycin is actively transported to the site of infection is because of its high concentration in phagocytic cells. Large concentrations of azithromycin are released during active phagocytosis. Azithromycin concentrations in tissue can be up to 50 times higher than those in plasma. This results from ions being trapped and lipids having a high solubility.

A single large dose of azithromycin can be administered while still maintaining bacteriostatic levels in infected tissue for several days thanks to its long half-life. Plasma azithromycin concentrations decreased polyphasically after a single 500 mg dose, with a mean apparent plasma clearance of 630 ml/min and a terminal elimination half-life of 68 hours. The extensive absorption and subsequent release of the drug from the tissues are thought to be the cause of the prolonged terminal half-life. The main method of elimination for azithromycin is primarily unchanged excretion. Approximately 6% of the administered dose continued to show up unchanged in the urine after a week.

Microbiology: 

  • Azithromycin inhibits the synthesis of microbial proteins by attaching to the 50S ribosomal subunit of susceptible microorganisms. Nucleic acid synthesis is not impacted. Both in vitro and in human infections, azithromycin has been shown to be effective against the majority of the isolates listed below:
  • Gram-positive bacteria that can be easily grown in an aerobic environment include staphylococcus aureus, streptococcus agalactiae, streptococcus pneumonia, and streptococcus pyogenes. Neisseria gonorrhoeae, Moraxella catarrhalis, Haemophilus ducreyi, and Haemophilus influenzae
  • Other microorganisms include Chlamydia pneumoniae, Mycoplasma pneumoniae, and Chlamydia trachomatis-producing organisms. The activity of azithromycin is not anticipated to be impacted by beta-lactamase.
  • Gram-positive bacteria that are both aerobic and anaerobic: Streptococci (Groups C, F, and G), Streptococci from the group Viridans
  • Gram-negative bacteria that are aerobic and simple to grow include Legionella pneumophila and Bordetella pertussis
  • Prevotella Livia and Peptostreptococcus species are examples of anaerobic microbes.

 Dosage & Administration of Rozith 15 ml Powder For Suspension

Oral-

Adult:

  • Orally take 500 mg once a day for three days, or take 250 mg once a day for four days, starting with 250 mg on day one.
  • Adults who have Chlamydia trachomatis-related STDs should take 1 gm as a single dose, or 500 mg once on day 1, followed by 250 mg once daily for the following 2 days.

Children:

  • Children over 6 months: 10 mg/kg body weight once daily for 3 days
  • If your weight is between 15 and 25 kilograms, take 200 mg daily for three days.
  • For three days, take 300 mg (112 teaspoonfuls) if your body weight is between 26 and 35 kg and 400 mg (2 teaspoonfuls) if it's between 36 and 45 kg.
  • Typhoid fever is treated with 500 mg (212 teaspoons) once daily for 7–10 days.

Administration of Rozith 15 ml Powder For Suspension

Reconstitution procedure of suspension-

  • Step 01: Shake the bottle well to loosen the powder.
  • Step 02: Add boiled and cooled water up to the watermark on the bottle label.
  • Step 03: Shake until powder is completely mixed with water.
  • Azithromycin should be taken at least 1 hour before or 2 hours after a meal.

Interaction of Rozith 15 ml Powder For Suspension

In the presence of food and antacids, azithromycin absorption was decreased. Azithromycin should therefore be given either one hour before or two hours after eating or taking antacids. If azithromycin is used concurrently with digoxin and ergot derivatives, careful patient monitoring is advised because there is a chance of increased digoxin concentration and a theoretical chance of ergotism. Azithromycin and warfarin, theophylline, carbamazepine, methylprednisolone, and cimetidine have not been found to interact pharmacokinetically.

Contraindications of Rozith 15 ml Powder For Suspension

Rozith® is contraindicated in patients with known hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.

Rozith 15 ml Powder For Suspension Side Effects

Low incidences of side effects are associated with azithromycin's well-tolerance. The gastrointestinal system's side effects, including diarrhea, nausea, abdominal pain, flatulence, and melena, are the most frequently reported ones. There have been reports of allergic reactions like rash, edema, and urticaria as well as rare cases of severe hypersensitivity reactions. Although no link to azithromycin has been proven, transient mild decreases in neutrophil counts have occasionally been seen in clinical trials.

Pregnancy & Lactation

Pregnancy: Pregnancy Category B. In the animal studies, no evidence of harm to the fetus due to azithromycin was found. Animal reproduction studies are not always predictive of human response; azithromycin should be used during pregnancy only if clearly needed.

Nursing Mothers: It is not known whether azithromycin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when azithromycin is administered to a nursing woman.

Precautions & Warnings

The liver is the principal route of elimination of azithromycin, caution should be exercised when azithromycin is administered to patients with impaired hepatic function. If any allergic reaction occurs, the drug should be discontinued and appropriate therapy should be instituted.

Storage Conditions of Rozith 15 ml Powder For Suspension

Store at 5-30 ºC in a dry place, protect from light.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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