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Sefur 125 Tablet | 1 Strip
Cefuroxime is a broad-spectrum, bactericidal cephalosporin antibiotic effective against many common pathogens, including beta-lactamase-producing strains. It is stable against bacterial beta-lactamase enzymes, making it effective against ampicillin- and amoxicillin-resistant bacteria.
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✅ Description:
Sefur 125 is used to treat infections caused by bacteria that are sensitive to it, including:
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
- Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (including beta-lactamase-producing strains), or Streptococcus pyogenes
- Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non-beta-lactamase-producing strains)
- Lower respiratory tract infections (including pneumonia) caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase and non-penicillinase producing), Streptococcus pyogenes, and E. coli
- Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase-negative), or Haemophilus parainfluenzae (beta-lactamase-negative)
- Skin and soft tissue infections caused by Staphylococcus aureus (including beta-lactamase-producing strains) or Streptococcus pyogenes
- Urinary tract infections caused by E. coli or Klebsiella pneumoniae
- Bone and joint infections caused by Staphylococcus aureus (penicillinase and non-penicillinase producing strains)
- Gonorrhoea caused by penicillinase and non-penicillinase-producing Neisseria gonorrhoeae
- Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi
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✔️ Side Effects
Generally mild and short-lived, including rash and gastrointestinal upset. Prolonged use may lead to overgrowth of non-susceptible organisms (e.g., Candida).
✔️ Dosage & Administration
Oral (Tablets/Suspension)
Adults & adolescents (13+ years)
Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days
Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days
Acute exacerbations of chronic bronchitis: 250–500 mg twice daily for 10 days
Secondary bacterial infections of acute bronchitis: 250–500 mg twice daily for 5–10 days
Uncomplicated skin/skin-structure infections: 250–500 mg twice daily for 10 days
Uncomplicated UTI: 250 mg twice daily for 7–10 days
Uncomplicated Gonorrhoea: Single dose of 1000 mg
Community-acquired pneumonia: 250–500 mg twice daily for 5–10 days
MDR Typhoid Fever: 500 mg twice daily for 10–14 days
Early Lyme disease: 500 mg twice daily for 20 days
Children (3 months–12 years)
Pharyngitis/Tonsillitis: 20 mg/kg/day in 2 doses for 5–10 days
Acute otitis media: 30 mg/kg/day in 2 doses for 10 days
Acute bacterial maxillary sinusitis: 30 mg/kg/day in 2 doses for 10 days
Impetigo: 30 mg/kg/day in 2 doses for 10 days
Parenteral (Injection)
Adults: 750 mg IM/IV every 8 hours; severe infections up to 1.5 g every 8 hours. May increase to 4 doses/day if needed (3–6 g/day).
Children (over 3 months): 30–100 mg/kg/day in 3–4 doses (60 mg/kg/day for most infections).
Neonates: 30–100 mg/kg/day in 2–3 doses.
Special cases:
Surgical prophylaxis: 1.5 g IV at anesthesia induction, followed by up to 3 doses of 750 mg every 8 hours for high-risk procedures.
Pneumonia: 1.5 g IV twice daily for 2–3 days, then switch to 500 mg orally twice daily for 7–10 days.
Acute bronchitis exacerbation: 750 mg twice daily for 2–3 days, then 500 mg orally twice daily for 5–10 days.
Gonorrhoea: 1.5 g as a single dose (two 750 mg injections at separate sites).
Meningitis: Adults 3 g IV every 8 hours; children 200–240 mg/kg/day IV in 3–4 doses (reduce after improvement); neonates 100 mg/kg/day IV (reduce to 50 mg/kg/day when indicated).
Bone/joint infections: Adults 1.5 g IV every 6 hours; children 150 mg/kg/day divided into doses every 8 hours (max adult dose).
✔️ Interactions
No significant hazardous drug interactions reported.
✔️ Contraindications
Do not use in patients allergic to cephalosporins.
✔️ Pregnancy & Lactation
FDA Pregnancy Category B. Use only if needed. Excreted in breast milk—use with caution in nursing women.
✔️ Precautions & Warnings
Use cautiously in patients taking strong diuretics or with a history of colitis. Cross-reactivity may occur in penicillin-allergic patients.
✔️ Storage
Keep in a cool, dry place (below 30°C), protected from light and moisture. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
