TAF 25mg Tablet | Hepatitis B Infection | 10pcs | Buy | ePharma
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TAF 25mg Tablet

Generic: Tenofovir Alafenamide

Type: Tablet

Pack Size: 10pcs

TAF 25mg Tablet is used in the treatment of Chronic Hepatitis B Virus (HBV) Infection.


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Discount Price: ৳ 1520
MRP: ৳ 1600 5% Off

⪼ Save  ৳: 80  in this Product


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✅ Description:

Tenofovir Alafenamide, an antiviral medication, is used to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease. It inhibits HBV replication by incorporating the HBV reverse transcriptase into viral DNA, leading to DNA chain termination and preventing the production of new viruses. Take as prescribed by your doctor, and be cautious about potential side effects such as headaches, diarrhea, vomiting, nausea, and rash. Avoid Tenofovir Alafenamide if you are allergic to it or have a history of severe kidney or liver impairment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, and avoid alcohol consumption while taking this medication. Exercise caution when driving or using machinery due to potential dizziness. Not suitable for children under 12. Take precautions to avoid infecting others.

Safety Advices


Alcohol
UNSAFE

Alcohol can increase the side effects of TAF 25mg Tablet such as dizziness, liver damage, and headache. Thus, you should avoid alcohol while on this medicine.


Pregnancy
SAFE IF PRESCRIBED

TAF 25mg Tablet should be used with caution during pregnancy only if considered clearly necessary. Consult your doctor before taking TAF 25mg Tablet


Breastfeeding
CONSULT YOUR DOCTOR

TAF 25mg Tablet is not recommended for use in breastfeeding women as the medicine passes to the baby through breast milk. Consult your doctor before taking TAF 25mg Tablet.


Driving
UNSAFE

Do not drive or use any machines if you feel dizzy after taking the TAF 25mg Tablet.


Kidney
CONSULT YOUR DOCTOR

TAF 25mg Tablet should be used with caution in patients with kidney disease or problems. Consult your doctor before taking TAF 25mg Tablet.


Liver
CONSULT YOUR DOCTOR

TAF 25mg Tablet should be used with caution in patients with a history of liver disease, including hepatitis C or D (a viral liver infection that leads to serious liver damage). Consult your doctor before taking TAF 25mg Tablet.

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✔️ Uses of Taf 25mg Tablet
  • Treats long-term hepatitis B infection
✔️ How does Taf 25mg Tablet work?

TAF 25mg Tablet works by inhibiting an enzyme (viral polymerase), causing chain termination, which in turn, inhibits DNA synthesis and viral replication, thereby preventing the virus from producing new viruses and stopping the infection from spreading.

✔️ Side Effects of Taf 25mg Tablet
  • Headache
  • Cough
  • Back pain
  • Nausea and Vomiting
  • Troubled breathing
  • swelling of the face, finger, or lower legs
  • Unusual tiredness or weakness
  • Increased blood pressure
  • Sleepiness
  • Loss of appetite
  • A general feeling of discomfort
  • Diarrhea
  • Dizziness
✔️ Quick Suggestions:
  • You have been prescribed TAF 25mg Tablet for the treatment of chronic hepatitis B virus (HBV) infection.
  • In combination with other medicines, it is used for the treatment of HIV infections.
  • Take it with food, as this increases the absorption of the medicine into the body.
  • TAF 25mg Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • You may still develop infections or other illnesses associated with viral infection while taking this medication.
  • You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
  • During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus, and blood cells in your blood.
✔️ Indication

TAF 25mg Tablet is used for the treatment of adult patients suffering from Human Immunodeficiency Virus (HIV) infection.

✔️ Pharmacology

Tenofovir alafenamide (AF) is a nucleotide reverse transcriptase inhibitor (NRTI) and a prodrug of tenofovir. Unlike tenofovir disoproxil fumarate (tenofovir DF or Viread), tenofovir AF is a more targeted form of tenofovir. It has shown highly effective antiviral activity at a dose that is 10 times lower than tenofovir DF and offers improved safety for the kidneys and bones.

Tenofovir AF is a lipophilic compound that can easily penetrate cells. It enters primary hepatocytes through passive diffusion and by utilizing hepatic uptake transporters like OATP1B1 and OATP1B3. Once inside the cell, it is converted into tenofovir diphosphate. Tenofovir diphosphate inhibits HBV replication by becoming part of the viral DNA during the reverse transcription process, ultimately leading to DNA chain termination and stopping viral replication.

✔️ Dosage & Administration of TAF 25mg Tablet

Adult Dose

Chronic Hepatitis B Infection: TAF 25mg Tablet is indicated for the treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease. The recommended dose is 25 mg taken orally once daily with food.

Hepatic Impairment

  • Mild Hepatic Impairment (Child-Pugh A): No dosage adjustment is required.
  • Decompensated Hepatic Impairment (Child-Pugh B or C): Use is not recommended in patients with decompensated hepatic impairment.

Renal Dose

  • Renal Impairment (Mild, Moderate, or Severe): No dosage adjustment is required.
  • End-Stage Renal Disease (CrCl <15 mL/min): Use is not recommended.

Take TAF 25mg Tablet as prescribed by your physician. Swallow the tablet with a glass of water. Your doctor will determine the appropriate dose and duration based on your age, body weight, and the severity of your disease. Do not discontinue TAF 25mg Tablet unless advised to do so by your doctor.

✔️ Interaction

Before taking TAF 25mg Tablet, it's important to inform your doctor if you are currently taking any of the following medications:

  • Other medications used to treat hepatitis B infection (e.g., tenofovir alafenamide, tenofovir disoproxil, adefovir dipivoxil)
  • Ritonavir or cobicistat boosted darunavir, lopinavir, atazanavir (used in the treatment of HIV infection)
  • Medications used to treat bacterial infections, including tuberculosis (e.g., rifabutin, rifampicin, rifapentine)
  • Medications used to manage seizures (e.g., carbamazepine, oxcarbazepine, phenobarbital, phenytoin)
  • St. John’s wort (an herbal remedy for depression and anxiety)
  • Medications used to treat fungal infections (e.g., ketoconazole or itraconazole)
✔️ Contraindications

If you are allergic to tenofovir or any other ingredient of TAF 25mg Tablet.

✔️ Pregnancy & Lactation

The use of TENOFOVIR ALAFENAMIDE in pregnant women lacks sufficient human data to assess potential risks of adverse fetal developmental outcomes. However, animal studies did not show any adverse effects on fetal development when tenofovir alafenamide was administered during the period of organogenesis. These studies were conducted at exposure levels equal to or 51 times higher than the tenofovir alafenamide exposure at the recommended daily dose in both rats and rabbits.

It's important to note that findings in animal studies may not always directly translate to humans, and caution is typically exercised when considering medication use during pregnancy. The decision to use TENOFOVIR ALAFENAMIDE during pregnancy should be made by a healthcare provider after a thorough evaluation of the potential benefits and risks for the individual patient.

Pregnant women or those planning to become pregnant should consult their healthcare provider for guidance on the most appropriate treatment options and considerations for their specific situation.

✔️ Precautions & Warnings

Here are some important points to consider regarding the use of TENOFOVIR ALAFENAMIDE:

  • Lactic Acidosis and Hepatomegaly: Lactic acidosis (excess lactic acid in the blood) and severe hepatomegaly (enlarged liver with fat accumulation) have been reported with the use of nucleoside analogs, including tenofovir disoproxil fumarate, especially when used in combination with other antiretroviral drugs. Most of these cases were reported in women, and risk factors may include obesity and prolonged exposure to nucleoside analogs.
  • Hepatitis B Exacerbation: Discontinuation of antihepatitis B drugs, including tenofovir alafenamide, can lead to severe acute exacerbations of hepatitis B. Therefore, treatment should not be abruptly stopped without medical supervision.
  • HIV-1 Resistance: Tenofovir alafenamide alone is not recommended for the treatment of HIV-1 infection. Before initiating treatment, patients should be tested for HIV-1. Using tenofovir alafenamide alone for HIV-1 treatment can lead to the development of HIV-1 resistance.
  • Lactation: It is unknown whether tenofovir alafenamide is distributed in human breast milk. Healthcare providers should consider the potential risks and benefits of breastfeeding while taking into account the mother's clinical need for the drug and any potential adverse effects on the breastfed infant, either from the drug or the mother's underlying condition.
✔️ Storage Conditions
  • Store at a temperature below 30°C.
  • Keep it out of reach of children and pets.
  • Do not throw away any medicines via wastewater or household waste.
Frequently Asked Questions (FAQ)

Hepatitis B is a potentially deadly liver infection caused by the hepatitis B virus (HBV). It is highly contagious and spreads through intimate contact with an infected person, direct exposure to infected blood, the use of contaminated needles or personal items, or transmission from mother to baby during childbirth. The virus can survive outside the body for up to a week. Chronic hepatitis B progresses slowly, and symptoms may not appear until complications arise. Symptoms can manifest three months after exposure and last for two to twelve weeks. Consequences of chronic hepatitis B include liver failure, liver cancer, and cirrhosis. Fortunately, hepatitis B can be prevented through vaccination.

If you have vomited a dose of TAF 25mg Tablet in less than 1 hour after taking it, take another medicine. Do not take another dose if you vomit the medicine more than 1 hour after taking it.

No, TAF 25mg Tablet is used for adults and not recommended for use in children who are (younger than 12 years of age or weighing less than 35 kgs). Child’s doctor will decide the correct dose or select a suitable alternative therapy for your child.

It is important not to miss a dose of TAF 25mg Tablet but if you do, take the next dose as soon as possible if you remember within 18 hours of previous dose. Do not take the forgotten dose if you remember after 18 hours or more of previous dose. Wait and take your next dose as per schedule.

Yes, you can still pass the infection to others while taking TAF 25mg Tablet. It does not reduce the risk of infecting others with hepatitis B through sexual contact or blood contamination. Discuss the precautionary measures needed with your doctor to avoid infecting others.

TAF 25mg Tablet may start showing its action within one hour.

TAF 25mg Tablet may remain in your body for approximately 4 days.

A blood test (HBsAg blood test) can be used to determine if you have hepatitis B or have ever had it.
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Check our pricing section for TAF 25mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.

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