TAF 25mg Tablet is used in the treatment of Chronic Hepatitis B Virus (HBV) Infection.
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Tenofovir Alafenamide, an antiviral medication, is used to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease. It inhibits HBV replication by incorporating the HBV reverse transcriptase into viral DNA, leading to DNA chain termination and preventing the production of new viruses. Take as prescribed by your doctor, and be cautious about potential side effects such as headaches, diarrhea, vomiting, nausea, and rash. Avoid Tenofovir Alafenamide if you are allergic to it or have a history of severe kidney or liver impairment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, and avoid alcohol consumption while taking this medication. Exercise caution when driving or using machinery due to potential dizziness. Not suitable for children under 12. Take precautions to avoid infecting others.
Alcohol can increase the side effects of TAF 25mg Tablet such as dizziness, liver damage, and headache. Thus, you should avoid alcohol while on this medicine.
TAF 25mg Tablet should be used with caution during pregnancy only if considered clearly necessary. Consult your doctor before taking TAF 25mg Tablet
TAF 25mg Tablet is not recommended for use in breastfeeding women as the medicine passes to the baby through breast milk. Consult your doctor before taking TAF 25mg Tablet.
Do not drive or use any machines if you feel dizzy after taking the TAF 25mg Tablet.
TAF 25mg Tablet should be used with caution in patients with kidney disease or problems. Consult your doctor before taking TAF 25mg Tablet.
TAF 25mg Tablet should be used with caution in patients with a history of liver disease, including hepatitis C or D (a viral liver infection that leads to serious liver damage). Consult your doctor before taking TAF 25mg Tablet.
TAF 25mg Tablet works by inhibiting an enzyme (viral polymerase), causing chain termination, which in turn, inhibits DNA synthesis and viral replication, thereby preventing the virus from producing new viruses and stopping the infection from spreading.
TAF 25mg Tablet is used for the treatment of adult patients suffering from Human Immunodeficiency Virus (HIV) infection.
Tenofovir alafenamide (AF) is a nucleotide reverse transcriptase inhibitor (NRTI) and a prodrug of tenofovir. Unlike tenofovir disoproxil fumarate (tenofovir DF or Viread), tenofovir AF is a more targeted form of tenofovir. It has shown highly effective antiviral activity at a dose that is 10 times lower than tenofovir DF and offers improved safety for the kidneys and bones.
Tenofovir AF is a lipophilic compound that can easily penetrate cells. It enters primary hepatocytes through passive diffusion and by utilizing hepatic uptake transporters like OATP1B1 and OATP1B3. Once inside the cell, it is converted into tenofovir diphosphate. Tenofovir diphosphate inhibits HBV replication by becoming part of the viral DNA during the reverse transcription process, ultimately leading to DNA chain termination and stopping viral replication.
Adult Dose
Chronic Hepatitis B Infection: TAF 25mg Tablet is indicated for the treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease. The recommended dose is 25 mg taken orally once daily with food.
Hepatic Impairment
Renal Dose
Take TAF 25mg Tablet as prescribed by your physician. Swallow the tablet with a glass of water. Your doctor will determine the appropriate dose and duration based on your age, body weight, and the severity of your disease. Do not discontinue TAF 25mg Tablet unless advised to do so by your doctor.
Before taking TAF 25mg Tablet, it's important to inform your doctor if you are currently taking any of the following medications:
If you are allergic to tenofovir or any other ingredient of TAF 25mg Tablet.
The use of TENOFOVIR ALAFENAMIDE in pregnant women lacks sufficient human data to assess potential risks of adverse fetal developmental outcomes. However, animal studies did not show any adverse effects on fetal development when tenofovir alafenamide was administered during the period of organogenesis. These studies were conducted at exposure levels equal to or 51 times higher than the tenofovir alafenamide exposure at the recommended daily dose in both rats and rabbits.
It's important to note that findings in animal studies may not always directly translate to humans, and caution is typically exercised when considering medication use during pregnancy. The decision to use TENOFOVIR ALAFENAMIDE during pregnancy should be made by a healthcare provider after a thorough evaluation of the potential benefits and risks for the individual patient.
Pregnant women or those planning to become pregnant should consult their healthcare provider for guidance on the most appropriate treatment options and considerations for their specific situation.
Here are some important points to consider regarding the use of TENOFOVIR ALAFENAMIDE:
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