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Varizil IV 500mg/100ml Infusion
Varizil IV 500mg/100ml Infusion (Metronidazole) is an antibiotic used to treat various bacterial and parasitic infections. It should be taken with food, and the prescribed dose should be followed strictly. Even if symptoms improve, the full course of treatment should be completed.
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✅ Description:
Indications of Varizil 500 mg/100 ml:
Varizil 500 mg/100 ml is indicated for the treatment of the following conditions:
- Prevention of post-operative infections due to anaerobic bacteria, especially species of bacteroides and anaerobic streptococci.
- Treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, and post-operative wound infections caused by anaerobes.
- Urogenital trichomoniasis.
- Bacterial vaginosis (also known as non-specific vaginitis).
- All forms of amoebiasis (intestinal, extra-intestinal disease, and asymptomatic cyst passers).
- Giardiasis.
- Acute ulcerative gingivitis.
- Anaerobically infected leg ulcers and pressure sores.
- Acute dental infections due to anaerobic organisms.
- Antibiotic-associated pseudomembranous colitis.
Safety Advices
Alcohol
UNSAFE
It is unsafe to consume alcohol while taking Varizil IV 500mg/100ml Infusion as it may cause a disulfiram reaction, leading to symptoms like flushing, increased heart rate, nausea, and low blood pressure.
Pregnancy
CONSULT YOUR DOCTOR
Varizil IV 500mg/100ml Infusion is generally considered safe to use during pregnancy, but it should be taken only if prescribed by a doctor. Limited human studies are available, so caution is advised.
Breastfeeding
CONSULT YOUR DOCTOR
Caution is recommended while using Varizil IV 500mg/100ml Infusion during breastfeeding. It's advisable to hold breastfeeding until the treatment is completed and the drug is eliminated from the body. If a single dose is taken, breastfeeding should be avoided for 12-24 hours.
Driving
CAUTION
Varizil IV may cause side effects such as drowsiness, dizziness, confusion, hallucinations, and temporary eyesight problems, which can impair driving ability. It is advised to avoid driving if you experience these side effects.
Kidney
CAUTION
Varizil IV is safe to use in patients with kidney disease, and no dose adjustment is necessary. However, patients undergoing kidney dialysis should take this medicine after dialysis treatment.
Liver
CAUTION
Caution is advised when using Varizil IV in patients with liver disease. Dose adjustment may be necessary, so it's essential to consult a doctor.
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✔️ Overdose Effects:
Overdose of Varizil 500 mg/100 ml may result in symptoms such as vomiting, ataxia, and disorientation. Symptomatic and supportive treatment should be instituted in case of suspected overdose.
✔️ Missed Dose:
If a dose of Varizil IV is missed, it should be taken as soon as possible. However, if it's almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule should be followed.
✔️ Pharmacology:
Varizil 500 mg/100 ml belongs to the imidazole class of antibacterial drugs and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of Varizil 500 mg/100 ml is metabolically reduced by anaerobes. The reduced form of the drug interacts with DNA, exerting a bactericidal action.
✔️ Dosage & Administration of Varizil IV 500mg/100ml Infusion
The dosage and administration of Varizil 500 mg/100 ml vary depending on the condition being treated, age, and weight of the patient. It is available in tablet, suspension, vaginal gel, suppository, and IV infusion forms. Dosage recommendations for various conditions and patient populations are provided in detail in the prescribing information.
Pediatric Uses: Varizil 500 mg/100 ml should be administered with caution in pediatric patients with hepatic or renal impairment. Dosage adjustments may be necessary based on the patient's condition.
✔️ Interaction:
Varizil 500 mg/100 ml may interact with drugs such as disulfiram, alcohol, oral anticoagulants, lithium, cyclosporin, phenytoin or phenobarbital, 5-fluorouracil, and busulfan, leading to potentiation or reduction of their effects. Close monitoring and dose adjustments may be necessary when co-administering Varizil 500 mg/100 ml with these drugs.
✔️ Contraindications:
Varizil 500 mg/100 ml is contraindicated in patients with a history of hypersensitivity to Varizil 500 mg/100 ml or other Nitroimidazole derivatives.
✔️ Side Effects of Varizil IV 500mg/100ml Infusion
Common side effects of Varizil 500 mg/100 ml may include metallic taste, nausea, vomiting, diarrhea, drowsiness, and rashes.
✔️ Pregnancy & Lactation:
Varizil 500 mg/100 ml falls under US FDA Pregnancy Category B. It should be used during pregnancy only if needed. Caution is advised when administering Varizil 500 mg/100 ml to nursing women due to excretion in human milk.
✔️ Precautions & Warnings:
Patients receiving Varizil 500 mg/100 ml for extended periods should undergo regular hematological tests, especially leucocyte count, and be monitored for adverse reactions such as neuropathy. Caution is advised in patients with hepatic encephalopathy. Patients should be warned about urine discoloration.
✔️ Storage Conditions:
Varizil 500 mg/100 ml should be stored below 30°C, protected from light, and kept out of reach of children. It should not be used after the expiration date.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
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lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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