Widebac IV Infusion (50mg/vial)

✔️ Uses of Widebac IV Infusion

Manage serious infections such as:

• Complicated infection of the skin and soft tissues (the tissue below the skin), excluding diabetic foot infections
• Complicated infection in the abdomen

✔️ How does Widebac IV Infusion work?

Widebac IV Infusion acts on the bacteria and disrupts the important life functions of the bacteria. It interferes with the present bacteria and disrupts the cell membrane hampering its various cellular functions which leads to bacterial death.

✔️ Side Effects of Widebac IV Infusion

Common side effects of Widebac IV Injection include headache, vomiting, nausea, increased liver enzymes, stomach pain, and diarrhea. These side effects are usually temporary and may improve as your body adjusts to the medication.

✔️ Quick Suggestions:

• Take Widebac IV Injection as prescribed without skipping doses, even if you start feeling better. Stopping the medication early may cause the infection to return or worsen.
• Inform your doctor if you experience persistent diarrhea or find blood in your stools during treatment.
• Before starting treatment, inform your doctor about your pregnancy status, breastfeeding, liver problems, and any allergies to antibiotics.
• Regular monitoring of liver function may be recommended during treatment with Widebac IV Injection.

✔️ Indication of Widebac IV Infusion

Widebac 50 mg/vial belongs to the tetracycline group of drugs. It acts as a glycylcycline by inhibiting bacterial protein translation at the 30S ribosomal subunit. This mechanism prevents amino-acyl tRNA molecules from entering the ribosome's A site, thereby halting peptide chain elongation. Widebac 50 mg/vial carries a glycylamido moiety at the 9-position of minocycline, a modification not found in naturally occurring or semi-synthetic tetracyclines. It is effective against a broad spectrum of bacteria and is not affected by common resistance mechanisms such as ribosomal protection, efflux pumps, or enzyme target modifications.

✔️ Pharmacology

Widebac IV Injection is a glycylcycline antibiotic that works by inhibiting bacterial protein synthesis. It binds to the 30S ribosomal subunit of bacteria, preventing the incorporation of amino acids into growing peptide chains. This action stops bacterial growth and helps in treating infections.

✔️ Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

✔️ Overdose Effects of Widebac IV Infusion

Widebac IV Infusion will be administered to you only by a doctor or a nurse in a hospital so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

✔️ How to manage common side effects:

Diarrhea:

• Stay Hydrated: Drink plenty of fluids such as water, electrolyte solutions, or fruit juice to prevent dehydration.
• Avoid Certain Foods: Stick to a bland diet that includes foods like bananas, rice, applesauce, and toast (BRAT diet) to help firm up stools.
• Consult Your Doctor: Do not take any over-the-counter medications for diarrhea without consulting your doctor first, especially if it persists.

Nausea:

• Eat Simple Meals: Stick to light, bland foods like crackers or plain rice.
• Avoid Triggers: Steer clear of spicy, rich, or greasy foods.
• Medication Advice: Do not take anti-nausea medications without your doctor’s approval, and discuss other options if nausea continues.

Headache:

• Rest: Lie down in a quiet, dark room to rest.
• Apply Cold Compress: Use a cold compress on your forehead to alleviate pain.
• Avoid Exertion: Stay away from strenuous activities that could worsen the headache.
• Consult Your Doctor: If headaches persist or are severe, seek medical advice.

Vomiting:

• Stay Hydrated: Sip clear fluids like water, broth, or electrolyte solutions to prevent dehydration.
• Choose Light Foods: Eat small, frequent meals of bland foods like toast or crackers.
• Avoid Triggers: Skip fried, oily, or overly sweet foods.
• Doctor’s Guidance: Consult your doctor if vomiting is severe or persistent.

Dizziness:

• Lie Down: If you feel dizzy, lie down or sit with your head resting until the sensation passes.
• Quiet Environment: Rest in a quiet, dark room with your eyes closed to help reduce dizziness.
• Avoid Driving: Refrain from driving or operating heavy machinery if you experience dizziness.
• Medical Consultation: Discuss any worsening symptoms or concerns with your doctor promptly.

Stomach Pain:

• Rest and Relax: Lie down and rest to ease stomach discomfort.
• Small Meals: Eat smaller, more frequent meals rather than large ones.
• Apply Heat: Use a heating pad or warm compress on your stomach to relieve pain.
• Seek Medical Advice: Consult your doctor if stomach pain persists or becomes severe.

Loss of Appetite:

• Eat Small, Nutritious Meals: Choose nutrient-rich foods that are easy to digest, such as fruits, nuts, and high-protein snacks.
• Consult Your Doctor: If appetite loss persists, talk to your doctor for further guidance and potential solutions.

Low Blood Sugar:

• Immediate Treatment: Consume glucose tablets, sweets, biscuits, or fruit juice to raise blood sugar levels quickly.
• Rest: Take a break and rest to stabilize your condition.
• Medical Attention: Seek medical advice if symptoms of low blood sugar do not improve or worsen.

✔️ Dosage:

The recommended dosage for adults is an initial dose of 100 mg followed by 50 mg every 12 hours via intravenous infusion over 30 to 60 minutes. The duration of treatment varies depending on the infection type, typically 5 to 14 days for skin infections and intra-abdominal infections, and 7 to 14 days for community-acquired pneumonia.

✔️ Administration:

Widebac IV Injection is administered by healthcare professionals either by drip or direct injection into a vein (intravenously) in a hospital setting. It's essential not to self-administer this medication

✔️ Interaction

Drug interaction of Widebac with Digoxin and Warfarin is observed.

✔️ Contraindications

Widebac 50 mg/vial should be used cautiously in patients with known hypersensitivity to tetracycline-class antibiotics. 

✔️ Pregnancy & Lactation

Special precautions apply during pregnancy and lactation, with use justified only if benefits outweigh potential risks to the fetus or nursing infant.

✔️ Precautions & Warnings

• Inform your doctor if you have kidney or liver problems before starting Tigecycline treatment. Adjustments to your dosage may be necessary.
• Inform your doctor if you have a history of colitis before using Tigecycline. This medication may worsen this condition.
• Notify your doctor if you have pancreatitis (inflammation of the pancreas) before starting Tigecycline treatment.
• Antibiotic therapy like Tigecycline can lead to CDAD. Inform your doctor if you develop persistent diarrhea during or after Tigecycline treatment.
• If you are receiving vaccinations with live bacterial vaccines (e.g., typhoid vaccine), discuss with your doctor. Tigecycline may interfere with the effectiveness of these vaccines.
• Tigecycline can cause increased sensitivity to sunlight (photosensitivity). Use sunscreen and protective clothing when outdoors to prevent sunburn.
• Tigecycline is not recommended during pregnancy due to potential harm to the unborn baby. Consult your doctor if you are pregnant or planning pregnancy. It may pass into breast milk, so discuss breastfeeding considerations with your doctor.
• Tigecycline may cause dizziness. Avoid driving or operating machinery until you know how Tigecycline affects you.
• Tigecycline is generally not recommended for children under eight years old due to potential effects on bone development.

✔️ Before Reconstitution:

• Store Widebac IV Injection vials in a refrigerator at 2°C to 8°C (36°F to 46°F).
• Do not freeze the vials.

✔️ After Reconstitution:

• Once reconstituted, Widebac IV Injection may be stored at room temperature (approximately 20°C to 25°C or 68°F to 77°F) for up to 24 hours.
• During this period, the reconstituted solution can be kept for up to 6 hours in the vial itself and the remaining time in the intravenous bag.
• If refrigeration is preferred, the reconstituted solution can be stored in the refrigerator at 2°C to 8°C (36°F to 46°F) for up to 48 hours.
• It is important to immediately transfer the reconstituted solution into the intravenous bag before refrigerating to maintain sterility and stability.