Finen 20 | Finerenone | General Pharmaceuticals Ltd.
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Finen 20mg Tablet 10pcs

Generic: Finerenone

Type: Tablet

Pack Size: 10pcs

  • Finen 20 tablet is a prescription medication used in adults who have diabetes-related kidney disease
  • Reduces the chance of worsening kidney problems and lowers the risk of severe heart issues.
  • Helps prevent further decline in kidney function
  • Reduces the risk of heart attacks
  • Reduces the requirement for hospitalization caused by heart problems

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Discount Price: ৳ 1034
MRP: ৳ 1100 6% Off

⪼ Save  ৳: 66  in this Product


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✅ Description:

Finen 20mg Tablet contains Finerenone which belongs to a group of medicines called non-steroidal mineralocorticoid receptor antagonists. It is indicated in the management of chronic kidney disease (stages 3 and 4 with abnormal presence of albumin (a type of protein) in the urine) associated with type 2 diabetes in adults.

Finerenone works by blocking the action of certain hormones within the body that can damage your kidneys and heart. During management with Finen 20mg Tablet, your doctor will constantly monitor your kidney functions and blood potassium levels to analyze the safety and efficacy of the management.

Take Finen 20mg Tablet as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It can be taken with or without meals.

Do not eat grapefruit or drink grapefruit juice as long as you take Finen 20mg Tablet, as it could lead to unpleasant side effects. Before taking Finen 20mg Tablet, inform your doctor if you have high blood potassium levels. Do not take Finen 20mg Tablet if you are allergic to finerenone or have Addison’s disease.

Finen 20mg Tablet is not recommended for use in pregnant women unless your doctor states it is necessary. Women of childbearing potential must use a reliable contraceptive method to avoid pregnancy while taking this medicine. Do not take Finen 20mg Tablet during breastfeeding as it may pass through the breast milk and harm the nursing infant.

Safety Advices


Alcohol
UNSAFE

It is not known whether it is safe to consume alcohol with Finen 20mg Tablet. Please consult your doctor.


Pregnancy
CONSULT YOUR DOCTOR

Finen 20mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.


Breastfeeding
CONSULT YOUR DOCTOR

Finen 20mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.


Driving
CAUTION

It is not known whether Finen 20mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.


Kidney
CONSULT YOUR DOCTOR

Finen 20mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Kerendia 20mg Tablet is recommended.


Liver
CAUTION

Finen 20mg Tablet is safe to use in patients with liver disease. No dose adjustment of Kerendia 20mg Tablet is recommended.

Similar Products

✔️ Composition

FINERENONE

✔️ Uses of Finen 20mg Tablet

Finerenone is used to prevent chronic kidney disease.

✔️ Side Effects of Finen 20mg Tablet
  • High potassium level (hyperkalemia)
  • Weakness or tiredness
  • Feeling sick (nausea)
  • Numbness in the hands and lips
  • Muscle cramps
  • Decreased pulse rate
  • Low sodium level (hyponatremia)
  • Tiredness
  • Headache
  • Confusion
  • Muscle weakness, spasms or cramps
  • Decrease in how well the kidneys filter blood (glomerular filtration rate decreased)
  • High uric acid level (hyperuricaemia)
✔️ Quick Suggestions:
  • A healthy, balanced diet lowers your risk of kidney disease. Keep your blood pressure and cholesterol at a healthy level.
  • A well-balanced diet should include plenty of fruits and vegetables.
  • Include starchy foods such as potatoes, wholegrain bread, rice, or pasta in your main meal.
  • For a protein source, include beans or pulses, fish, eggs, or meat in your daily diet.
  • Limit intake of saturated fat, salt, and sugar.
  • Limit the amount of potassium or phosphate in your diet.
  • Quit smoking. Avoid or limit the consumption of alcohol.
  • Do not skip any laboratory appointments, as your doctor will need to regularly check your liver and kidneys and blood and urine samples.
✔️ Indications:

Management of chronic kidney disease (stages 3 and 4 with abnormal presence of albumin in the urine) associated with type 2 diabetes in adults

✔️ Pharmacology

Mechanism of Action:

  • Finerenone is a nonsteroidal, selective antagonist of the mineralocorticoid receptor (MR).
  • It blocks MR-mediated sodium reabsorption and MR overactivation in both epithelial (e.g., kidney) and nonepithelial (e.g., heart, blood vessels) tissues, which can contribute to fibrosis and inflammation.
  • Finerenone has high potency and selectivity for MR, with no significant affinity for androgen, progesterone, estrogen, or glucocorticoid receptors.

Pharmacokinetics:

  • Absorption: Finerenone is completely absorbed after oral administration, with an absolute bioavailability of 44%. Peak plasma concentration (Cmax) is achieved within 0.5 to 1.25 hours after dosing.
  • Distribution: Volume of distribution (Vss) is 52.6 L. Plasma protein binding is 92%, mainly to serum albumin.
  • Elimination: Terminal half-life is 2 to 3 hours. Systemic blood clearance is about 25 L/h.
  • Metabolism: Primarily metabolized by CYP3A4 (90%) and to a lesser extent by CYP2C8 (10%) to inactive metabolites. About 80% of the dose is excreted in urine.
✔️ Dosage & Administration of Finen 20mg Tablet
  • Starting Dose:
    • eGFR ≥60 mL/min/1.73 m²: 20 mg once daily
    • eGFR ≥25 to <60 mL/min/1.73 m²: 10 mg once daily
    • eGFR <25 mL/min/1.73 m²: Not recommended
  • Dose Adjustment: Increase dosage to 20 mg once daily after 4 weeks based on eGFR and serum potassium levels.
  • Pediatric Use: Safety and efficacy not established for those under 18.
  • Geriatric Use: No dose adjustment is required based on study data.
  • Hepatic Impairment: Avoid severe hepatic impairment. No adjustment is needed for mild/moderate impairment but monitor potassium levels.

Missed Dose: 

Take as soon as possible on the same day. If missed for a day, skip and resume the next dose as scheduled.

Overdose:

  • Symptoms: Likely hyperkalemia.
  • Treatment: Discontinue Finerenone. Standard treatment for hyperkalemia. Finerenone is not efficiently removed by hemodialysis.
  • Administration: Tablets can be taken with or without food. If swallowing is difficult, tablets can be crushed and mixed with water or soft foods.
✔️ Interaction
  • Strong CYP3A4 Inhibitors: Contraindicated (e.g., itraconazole, ketoconazole, ritonavir).
  • Moderate/Weak CYP3A4 Inhibitors: Monitor serum potassium and adjust the dose as needed.
  • Strong/Moderate CYP3A4 Inducers: Avoid use (e.g., rifampicin).
  • Drug-Food Interactions: Avoid grapefruit or grapefruit juice.
✔️ Contraindications
  • Strong CYP3A4 inhibitors
  • Adrenal insufficiency
✔️ Pregnancy & Lactation
  • Pregnancy: No data on risks. Animal studies show developmental toxicity. Avoid unless necessary.
  • Lactation: Likely present in breast milk. Avoid breastfeeding during and 1 day after treatment.
✔️ Precautions & Warnings
  • Monitor serum potassium and eGFR before and during treatment.
  • Do not start treatment if serum potassium >5.0 mEq/L.
✔️ Storage:

Store below 30°C, away from light and moisture. Keep out of reach of children.

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