Renvela 800mg Pot

✔️ Uses of Renvela

• Hyperphosphatemia

✔️ How does Renvela work?

Sevelamer binds to phosphorus in your diet and prevents it from being absorbed into your bloodstream.

✔️ Side Effects of Renvela

Nausea, vomiting, upper abdominal pain, constipation, diarrhea, and bloating.

• These side effects may decrease over time. If they persist or worsen, consult your doctor.

✔️ Quick Suggestions:

• Avoid or limit high phosphorus addictive foods (processed meats, instant puddings, sauces, spreadable cheeses, and beverage products).
• Avoid intake of alcoholic beverages with Sevelamer 800 as it can make you dehydrated and may increase the side effects.
• Make sure you drink plenty of fluids. This will help you clear out the extra phosphate and will help you overcome some.
• Sevelamer 800 is preferably taken with meals as it can bind to dietary phosphate and prevent its absorption into the bloodstream. Drink it with a full glass of water.
• Do not stop taking the Sevelamer 800 dose until your doctor says so.
• Do not use Sevelamer 800 if you have a history of bowel obstruction.

✔️ Indication of Renvela

• Control of hyperphosphatemia in adults receiving hemodialysis or peritoneal dialysis.
• Control of hyperphosphatemia in adults with chronic kidney disease (CKD) not on dialysis, with serum phosphorus ≥1.78 mmol/L.
• Should be part of a comprehensive treatment approach, potentially including calcium supplements and vitamin D3 or analogs to manage the renal bone disease.

✔️ Pharmacology

Sevelamer carbonate is a non-absorbed phosphate-binding polymer free of metals and calcium. It binds phosphate in the gastrointestinal tract through ionic and hydrogen bonding, reducing phosphate absorption and lowering serum phosphorus levels.

✔️ Dosage & Administration of Renvela

For End-Stage Renal Disease (ESRD) Hemodialysis and Hyperphosphatemia:

Initial Dose:

• Serum PO4 >9 mg/dL [2.91 mmol/L]: 1600 mg orally every 8 hours with meals.
• Serum PO4 7.5-9 mg/dL [2.42-2.91 mmol/L]: 1200-1600 mg orally every 8 hours with meals.
• Serum PO4 5.5-7.5 mg/dL [1.78-2.42 mmol/L]: 800 mg orally every 8 hours with meals.

Maintenance Dose:

• Serum PO4 >5.5 mg/dL [>1.78 mmol/L]: Increase dose by 400-800 mg per meal.
• Serum PO4 3.5-5.5 mg/dL [1.13-1.78 mmol/L]: Maintain current dose.
• Serum PO4 <3.5 mg/dL [1.13 mmol/L]: Decrease dose by 400-800 mg per meal.

Dosing Considerations:

• Titrate the dose by increasing it by 400-800 mg per meal at 2-week intervals.
• Do not exceed a total daily dose of 4 grams.

Switching from Calcium Acetate:

• Substitute 800 mg of Sevelamer 800 for 667 mg of calcium acetate.
• Substitute 1600 mg of Sevelamer 800 for 1334 mg of calcium acetate.
• Substitute 2400 mg of Sevelamer 800 for 2001 mg of calcium acetate.

Pediatric Dose:

• The safety and efficacy of Sevelamer 800 in children have not been established. It is not recommended for use in pediatric patients.

✔️ Interaction

Drug-Drug Interactions:

• Ciprofloxacin: Sevelamer 800 may decrease the absorption of ciprofloxacin. It should not be taken simultaneously with this antibiotic.
• Mycophenolate: Sevelamer 800 may affect the absorption of mycophenolate. Monitor blood concentrations if used together.
• Levothyroxine: Sevelamer 800 may reduce the effectiveness of levothyroxine. Monitor thyroid-stimulating hormone (TSH) levels.
• Erdafitinib: Interaction with erdafitinib may occur; consult your doctor.

Drug-Food Interactions:

• High-Phosphate Additives: Avoid high-phosphate additives in your diet as they can interfere with Sevelamer 800’s effectiveness.
• Alcohol: Avoid alcohol consumption as it can increase side effects.
• Multivitamins with Minerals: Sevelamer 800 may decrease the effectiveness of multivitamins with minerals. Take multivitamins at least 4 hours before or after taking Sevelamer 800.

Drug-Disease Interactions:

• Hypophosphatemia: Sevelamer 800 is contraindicated in patients with low phosphate levels.
• Bowel Obstruction and Perforation: Sevelamer 800 should not be used in cases of bowel obstruction or perforation.
• Severe Liver Disease: Use Sevelamer 800 with caution in patients with severe liver disease.

✔️ Contraindications

Do not use if allergic to any ingredients in Sevelamer 800.

✔️ Pregnancy & Lactation

Pregnancy and Breastfeeding: Use Sevelamer 800 with caution if you are pregnant or planning to become pregnant. It is not recommended for breastfeeding mothers, as it may pass into breast milk.

✔️ Precautions & Warnings

• Avoid use if you have low phosphate levels in your blood.
• Not suitable for those with bowel obstruction.
• Contains lactose (milk sugar). If you have lactose intolerance, consult your doctor.
• Inform your doctor if you have swallowing problems, motility issues, frequent vomiting, active inflammatory bowel disease, or have had major stomach or bowel surgery.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or breastfeeding before using Sevelamer 800.
• Do not use Sevelamer 800 if you are allergic to it.
• Avoid alcohol while taking Sevelamer 800 as it may cause unpleasant side effects.
• Sevelamer 800 should not be given to children under six years of age, as its safety and effectiveness in this age group have not been established.
• Regular monitoring of serum phosphate levels, and levels of vitamins D, A, E, K, and folic acid is advised while taking Sevelamer 800.

✔️ Storage:

• Store in a cool, dry place, protected from light.