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Stener 150mg Tablet 10pcs

Generic: Ursodeoxycholic Acid

Type: Tablet

Pack Size: 10 Pcs

Stener/Ursodeoxycholic Acid is used for the treatment of Dissolution of cholesterol-rich gallstones, Primary biliary cirrhosis, Prevention of gallstone formation in obese patients experiencing rapid weight loss


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Discount Price: ৳ 141
MRP: ৳ 150 6% Off

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✅ Description:

Ursodeoxycholic Acid (UDCA) is a bile acid medication commonly used to treat gallstone problems. Gallstones can lead to various symptoms such as jaundice, pain, and inflammation of the pancreas and gallbladder. They form when bile, typically a liquid, hardens in the gallbladder, often due to calcium deposits.

It's crucial to take Ursodeoxycholic Acid exactly as prescribed by your doctor. The dosage will depend on the severity of your condition, and your doctor will typically recommend taking the medication at bedtime, either daily or as directed. It's usually best to take the medication after a meal or with a light snack to enhance its effectiveness.

Ursodeoxycholic Acid should not be used if you have certain types of gallstones, such as cholesterol, radiopaque, or bile pigment stones, or if the stones are larger than 20 mm in diameter. Additionally, individuals allergic to bile acids should avoid using this medication.

Gallbladder stone dissolution with Ursodeoxycholic Acid may require several months of therapy. It's important to note that complete dissolution may not always occur, and recurrence of stones within five years has been observed in 50% of patients. Your doctor may recommend continuing the medication for one to three months after the stone is dissolved.

Regular blood work will be necessary to monitor the effects of the medication. Additionally, ultrasound imaging may be conducted at six-month intervals during the first year of therapy to assess progress. If you experience persistent symptoms such as nausea, vomiting, abdominal pain, or jaundice, it's important to report them to your doctor promptly.

The typical dosage of Ursodeoxycholic Acid is 8-10 mg/kg/day, divided into 2-3 doses. However, its use beyond 24 months has not been established, and approximately 30% of patients may experience stone recurrence after dissolution.

Always consult with an Internal Medicine Specialist or your healthcare provider before starting or changing any medication regimen.

Safety Advices


Alcohol
UNSAFE

Consumption of alcohol is not safe.


Pregnancy
CONSULT YOUR DOCTOR

Stener 150mg Tablet should be used in pregnant women only if considered necessary by the doctor. If you are pregnant or think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking Stener 150mg Tablet.


Breastfeeding
CONSULT YOUR DOCTOR

Stener 150mg Tablet should be used with caution if you are breastfeeding. Consult your doctor before taking this medicine.


Driving
SAFE

Stener 150mg Tablet does not affect the consciousness of the patient. It is safe to drive while taking this medicine.


Kidney
CONSULT YOUR DOCTOR

Limited information is available regarding its use in patients with kidney disease. Kindly consult your doctor before taking this medication.


Liver
CONSULT YOUR DOCTOR

Stener 150mg Tablet should be used with caution in patients with liver diseases. Your doctor might advise you for frequent liver examinations and tests during the treatment. Consult your doctor before taking the Stener 150mg Tablet.

Similar Products

✔️ Uses of Stener 150mg Tablet
  • Dissolution Of Cholesterol Gallstones
  • Primary Biliary Cirrhosis
✔️ How does Stener 150mg Tablet work?

This medication decreases the cholesterol content of bile and bile stones by reducing the secretion of cholesterol from the liver and the fractional reabsorption of cholesterol by the intestines

✔️ Side Effects of Stener 150mg Tablet
  • Diarrhea
  • Nausea
  • Abdominal Pain
  • Fatigue
  • Headache
  • Pruritus
  • Rash
  • Vomiting
  • Dyspepsia
  • Metallic Taste
✔️ Quick Suggestions:
  • Stener 150 should be taken after a meal with a glass of milk or water.
  • Eat a healthy diet, exercise regularly, and avoid alcohol intake.
  • Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
  • Your doctor may monitor your liver function and bilirubin levels every month for the next 3 months after the start of therapy, and every 6 months thereafter.
  • Do not stop taking the medication without talking to your doctor.
✔️ Indication of Stener 150mg Tablet

Ursodeoxycholic Acid is indicated for the treatment of Cholestasis (Jaundice), Viral Hepatitis, Alcoholic Fatty Liver, Primary Billiary Cirrhosis (PBC), Primary Sclerosing Cholangitis (PSC), Dissolution of Gallstones, and Non-Alcoholic Steato Hepatitis (NASH).

✔️ Pharmacology

Ursodeoxycholic Acid (UDCA) is a naturally occurring bile acid used to treat various hepatobiliary disorders. Its mechanism of action involves several pathways:

  • Decrease in Cholesterol Secretion: UDCA reduces the secretion of cholesterol in bile, which helps in preventing the formation of cholesterol gallstones.
  • Reduction in Cholesterol Absorption: UDCA reduces the absorption of cholesterol from the intestine, further contributing to the prevention of gallstone formation.
  • Suppression of Liver Cholesterol Synthesis: UDCA suppresses the synthesis of cholesterol in the liver, which is another mechanism by which it reduces cholesterol levels in bile.
  • No Inhibition of Bile Acid Synthesis: Unlike some other medications, UDCA does not inhibit the synthesis of bile acids. This alteration in bile composition from supersaturated to unsaturated helps in preventing gallstone formation.
  • Promotion of Cholesterol Crystal Complex Formation: UDCA promotes the formation of liquid cholesterol crystal complexes, facilitating the removal of cholesterol from the gallbladder into the intestine for expulsion.

UDCA provides therapeutic benefits in cholestatic liver diseases through several mechanisms:

Protection of Cholangiocytes: UDCA protects cholangiocytes (cells lining the bile ducts) against the cytotoxicity of hydrophobic bile acids, which helps in maintaining bile flow and preventing bile duct damage.

Stimulation of Hepatobiliary Secretion: UDCA stimulates the secretion of bile from hepatocytes (liver cells) into the bile ducts, aiding in the elimination of bile acids and waste products from the liver.

Protection against Bile Acid-Induced Apoptosis: UDCA protects hepatocytes against bile acid-induced apoptosis (cell death), thereby preserving liver function and preventing liver damage.

After oral administration, UDCA is completely absorbed in the upper intestine. The time to peak serum concentration varies from 30 to 150 minutes, with a rate of absorption ranging from 60-80%. Once absorbed, UDCA enters the portal vein and undergoes extraction from portal blood by the liver. In the liver, UDCA is conjugated with amino acids, such as glycine or taurine, and then secreted into the hepatic bile ducts. Small quantities of UDCA appear in the circulation, and very small amounts are excreted into the urine. The biological half-life of UDCA ranges from 3.5 to 5.8 days, indicating its relatively long duration of action.

✔️ Dosage & Administration of Stener 150mg Tablet

The recommended dosage of Ursodeoxycholic Acid (UDCA) varies depending on the specific condition being treated. Here are the dosage recommendations for different indications:

  • Dissolution of Gallstones: The typical dosage is 8-12 mg/kg/day, either as a single nighttime dose or divided into multiple doses throughout the day.
  • Primary Biliary Cholangitis (PBC): The usual dosage ranges from 10-15 mg/kg/day, divided into 2-4 doses throughout the day.
  • Acute Viral Hepatitis: The recommended dosage is 600 mg/day.
  • Alcoholic Fatty Liver Disease: The typical dosage is 300 mg/day.
  • Primary Sclerosing Cholangitis (PSC): The usual dosage ranges from 25-30 mg/kg/day.
  • Non-Alcoholic Steatohepatitis (NASH): The typical dosage ranges from 13-15 mg/kg/day.
✔️ Interaction

Before taking URSODIL 300MG TABLET, it's crucial to inform your doctor about any other medications you are currently taking to avoid potential drug interactions. Here are some medications that may interact with Stener 150mg Tablet:

  • Medicines used for birth control: Certain contraceptives containing levonorgestrel or ethinyl estradiol may interact with Stener 150mg Tablet.
  • Medicines used to treat acidity: Antacids containing aluminum hydroxide may interact with Stener 150mg Tablet.
  • Medicines used to lower cholesterol levels: Medications such as colestyramine, clofibrate, and colestipol, which are used to lower cholesterol levels, may interact with Stener 150mg Tablet.
  • Medicines used to treat infections: Antibiotics like ciprofloxacin and dapsone, used to treat infections, may interact with Stener 150mg Tablet.
  • Medicine used to treat hypertension: Blood pressure medications such as nitrendipine and rosuvastatin may interact with Stener 150mg Tablet.
  • Medicines used to reduce the activity of the immune system: Immunosuppressive drugs like ciclosporin may interact with Stener 150mg Tablet.
✔️ Contraindications:
  • Allergy to bile acids.
  • Calcified gallstones.
  • Inflammation of the gallbladder or the bile ducts.
  • Blockage of the common bile duct or cystic duct.
  • Frequent cramp-like pains in the upper abdomen.
  • Low bile flow in children.
  • Improper function of the gall bladder.
  • Use with caution in patients with liver diseases.
✔️ Pregnancy & Lactation
  • Should be taken during pregnancy only if advised by the doctor.
  • Use with caution in breastfeeding women. Ask your doctor’s advice before taking it.
✔️ Precautions & Warnings
  • Dietary restrictions: Avoid excessive intake of calories and cholesterol-rich foods while taking Stener to optimize its effectiveness.
  • Monitoring liver function: Liver function tests (LFTs) and bilirubin levels should be monitored regularly, particularly during the initial months of therapy. This helps assess the drug's impact on liver function and detect any abnormalities early on.
  • Risk of gallstone recurrence: Despite successful treatment, there is a risk of gallstone recurrence in some patients. Approximately 50% of successfully treated patients may develop further gallstones within 10 years.
  • Pregnancy and lactation: Use caution if you are pregnant or breastfeeding while taking StenerL. It's essential to discuss the potential risks and benefits with your doctor before initiating treatment during pregnancy or lactation.
  • Monitoring parameters: Monitor liver function tests monthly for the first three months of treatment, and then every six months thereafter. Regarding lactation, it's unclear if Stener is excreted in breast milk, so caution is advised.
✔️ Storage Conditions

Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.

Frequently Asked Questions (FAQ)

While taking Ursodeoxycholic Acid, avoid taking antacid preparations without consulting your medical practitioner, as they decrease the effectiveness of Ursodeoxycholic Acid. You should also avoid taking drugs like cholestyramine or colestipol while you are on Ursodeoxycholic Acid.

Ursodeoxycholic Acid acts on the liver and gets concentrated in the bile secreted from the liver. This, as a result, suppresses the synthesis and secretion of cholesterol by the liver, thereby decreasing the cholesterol levels in bile.

It is generally safe to use Ursodeoxycholic Acid. However, this medicine may have some common side effects, such as diarrhea. If diarrhea occurs for an extended period, your doctor may reduce the dose or suggest discontinuing the use of Ursodeoxycholic Acid.

It is advised to consume Ursodeoxycholic Acid with water or milk and can be taken with food or after food.

You are advised to take Ursodeoxycholic Acid as prescribed by your doctor. Your doctor might instruct you to take 2 to 3 doses per day and suggest taking the last dose at bedtime. Q:

Yes, there is a chance of weight gain with Ursodeoxycholic Acid, but it is not common. Patients suffering from liver problems consuming Ursodeoxycholic Acid might gain weight. Q:
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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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