Stener/Ursodeoxycholic Acid is used for the treatment of Dissolution of cholesterol-rich gallstones, Primary biliary cirrhosis, Prevention of gallstone formation in obese patients experiencing rapid weight loss
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Ursodeoxycholic Acid (UDCA) is a bile acid medication commonly used to treat gallstone problems. Gallstones can lead to various symptoms such as jaundice, pain, and inflammation of the pancreas and gallbladder. They form when bile, typically a liquid, hardens in the gallbladder, often due to calcium deposits.
It's crucial to take Ursodeoxycholic Acid exactly as prescribed by your doctor. The dosage will depend on the severity of your condition, and your doctor will typically recommend taking the medication at bedtime, either daily or as directed. It's usually best to take the medication after a meal or with a light snack to enhance its effectiveness.
Ursodeoxycholic Acid should not be used if you have certain types of gallstones, such as cholesterol, radiopaque, or bile pigment stones, or if the stones are larger than 20 mm in diameter. Additionally, individuals allergic to bile acids should avoid using this medication.
Gallbladder stone dissolution with Ursodeoxycholic Acid may require several months of therapy. It's important to note that complete dissolution may not always occur, and recurrence of stones within five years has been observed in 50% of patients. Your doctor may recommend continuing the medication for one to three months after the stone is dissolved.
Regular blood work will be necessary to monitor the effects of the medication. Additionally, ultrasound imaging may be conducted at six-month intervals during the first year of therapy to assess progress. If you experience persistent symptoms such as nausea, vomiting, abdominal pain, or jaundice, it's important to report them to your doctor promptly.
The typical dosage of Ursodeoxycholic Acid is 8-10 mg/kg/day, divided into 2-3 doses. However, its use beyond 24 months has not been established, and approximately 30% of patients may experience stone recurrence after dissolution.
Always consult with an Internal Medicine Specialist or your healthcare provider before starting or changing any medication regimen.
Consumption of alcohol is not safe.
Stener 150mg Tablet should be used in pregnant women only if considered necessary by the doctor. If you are pregnant or think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking Stener 150mg Tablet.
Stener 150mg Tablet should be used with caution if you are breastfeeding. Consult your doctor before taking this medicine.
Stener 150mg Tablet does not affect the consciousness of the patient. It is safe to drive while taking this medicine.
Limited information is available regarding its use in patients with kidney disease. Kindly consult your doctor before taking this medication.
Stener 150mg Tablet should be used with caution in patients with liver diseases. Your doctor might advise you for frequent liver examinations and tests during the treatment. Consult your doctor before taking the Stener 150mg Tablet.
This medication decreases the cholesterol content of bile and bile stones by reducing the secretion of cholesterol from the liver and the fractional reabsorption of cholesterol by the intestines
Ursodeoxycholic Acid is indicated for the treatment of Cholestasis (Jaundice), Viral Hepatitis, Alcoholic Fatty Liver, Primary Billiary Cirrhosis (PBC), Primary Sclerosing Cholangitis (PSC), Dissolution of Gallstones, and Non-Alcoholic Steato Hepatitis (NASH).
Ursodeoxycholic Acid (UDCA) is a naturally occurring bile acid used to treat various hepatobiliary disorders. Its mechanism of action involves several pathways:
UDCA provides therapeutic benefits in cholestatic liver diseases through several mechanisms:
Protection of Cholangiocytes: UDCA protects cholangiocytes (cells lining the bile ducts) against the cytotoxicity of hydrophobic bile acids, which helps in maintaining bile flow and preventing bile duct damage.
Stimulation of Hepatobiliary Secretion: UDCA stimulates the secretion of bile from hepatocytes (liver cells) into the bile ducts, aiding in the elimination of bile acids and waste products from the liver.
Protection against Bile Acid-Induced Apoptosis: UDCA protects hepatocytes against bile acid-induced apoptosis (cell death), thereby preserving liver function and preventing liver damage.
After oral administration, UDCA is completely absorbed in the upper intestine. The time to peak serum concentration varies from 30 to 150 minutes, with a rate of absorption ranging from 60-80%. Once absorbed, UDCA enters the portal vein and undergoes extraction from portal blood by the liver. In the liver, UDCA is conjugated with amino acids, such as glycine or taurine, and then secreted into the hepatic bile ducts. Small quantities of UDCA appear in the circulation, and very small amounts are excreted into the urine. The biological half-life of UDCA ranges from 3.5 to 5.8 days, indicating its relatively long duration of action.
The recommended dosage of Ursodeoxycholic Acid (UDCA) varies depending on the specific condition being treated. Here are the dosage recommendations for different indications:
Before taking URSODIL 300MG TABLET, it's crucial to inform your doctor about any other medications you are currently taking to avoid potential drug interactions. Here are some medications that may interact with Stener 150mg Tablet:
Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.
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