Ursocol 300mg Tablet | Biliary Cirrhosis | Gallbladder Stones | ePharma
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Ursocol 300mg Tablet

Generic: Ursodeoxycholic Acid

Type: Tablet

Pack Size: 10 Pcs

A medication called Ursocol 300mg Tablet is used to dissolve some types of gallstones, stop them from forming, and treat primary biliary cirrhosis, a type of liver disease. It is a bile acid that aids in the breakdown of cholesterol that has crystallized into gallbladder stones.


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Discount Price: ৳ 237.5
MRP: ৳ 250 5% Off

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✅ Description:

  • Ursocol 300mg Tablet includes Ursodeoxycholic Acid, which belongs to the class of drugs known as Hepatoprotective agents. It is employed in the treatment of primary biliary cirrhosis. (damage of bile ducts in the liver leading to build up of bile).
  • Ursocol 300mg Tablet is also used to dissolve tiny gallstones (less than 15mm in diameter) in individuals with a functional gall bladder. Gallstones are hardened deposits of cholesterol that can develop in the gallbladder and cause sudden, excruciating pain in the upper right side of the abdomen.
  • Ursocol 300mg Tablet can also be used to treat cystic fibrosis-related liver damage in children aged 6 to 18 years.
  • Cystic fibrosis is a condition that affects the cells that create mucus, perspiration, and digestive juices, causing these fluids to thicken and cling together, clogging tubes, ducts, and passages.
  • During or after treatment with Ursocol 300mg Tablet, your doctor may order a variety of diagnostic tests, including a liver function test and a gallbladder scan.
  • Ursocol 300mg Tablet is not recommended for use in patients with bile acid allergies, calcified gallstones, gallbladder or bile duct inflammation, blockage of the common bile duct or cystic duct, frequent cramp-like pains in the upper abdomen, low bile flow in children, or improper gall bladder function. In individuals with liver problems, Ursocol 300mg Tablet should be taken with care.
  • Ursocol 300mg Tablet should be used only if specifically suggested by a doctor during pregnancy, and should be used with caution in breast-feeding women. Before taking any medication, consult your doctor. Ursocol 300mg Tablet is suitable for children, teenagers, and the elderly. Your doctor will determine the appropriate dose and duration of Ursocol 300mg Tablet treatment for you.
  • Soft, loose stools or diarrhea are the most prevalent adverse effects of taking Ursocol 300mg Tablet. If your symptoms increase or do not improve, see your doctor.

Safety Advices


Alcohol
UNSAFE

Avoid consumption of alcohol while taking Ursocol 300mg Tablet as it may cause increased dizziness and liver damage.


Pregnancy
CONSULT YOUR DOCTOR

Ursocol 300mg Tablet should be used in pregnant women only if considered clearly necessary by the doctor. If you are pregnant or think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking Ursocol 300mg Tablet.


Breastfeeding
SAFE IF PRESCRIBED

Ursocol 300mg Tablet should be used with caution in breastfeeding women as it is not known if it passes through breast milk. Consult your doctor if you are breastfeeding or about to start breastfeeding before taking Ursocol 300mg Tablet.


Driving
SAFE

Ursocol 300mg Tablet has no or negligible effect on driving or using machines.


Kidney
CONSULT YOUR DOCTOR

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.


Liver
CONSULT YOUR DOCTOR

Ursocol 300mg Tablet should be used with caution in patients with liver diseases. Your doctor might advise you for frequent liver examinations and tests during the treatment. Consult your doctor before taking the Ursocol 300mg Tablet

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✔️ Uses of Ursocol 300mg Tablet
  • Treatment of Primary Biliary Cirrhosis (bile acid-associated liver damage)
  • Treatment of Gallbladder stones
✔️ How Ursocol 300mg Tablet works?

By improving bile flow through the liver and preserving liver cells, Ursocol 300mg Tablet helps to reduce elevated liver enzyme levels. Ursocol 300mg Tablet is a bile concentrate that reduces biliary cholesterol by blocking the synthesis of new cholesterol through intestinal absorption. Lowering cholesterol levels progressively solubilizes cholesterol from gallstones, resulting in their disintegration.

 

✔️ Side Effects of Ursocol 300mg Tablet
  • Diarrhea
  • Indigestion
  • Bladder pain
  • Nausea or Vomiting
  • Unusual bleeding
  • Weakness
✔️ Quick Suggestions:
  • Ursocol 300 should be taken after a meal with a glass of milk or water.
  • Foods rich in vitamins B, C, and calcium, are good for the gallbladder.
  • Eat a healthy diet, exercise regularly
  • Avoid tobacco and alcohol consumption.
  • Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
  • Your doctor may monitor your liver function and bilirubin levels every month for the next 3 months after the start of therapy, and every 6 months thereafter.
  • Do not stop taking the medication without talking to your doctor.
✔️ Indication of Ursocol 300mg Tablet

Ursodeoxycholic Acid helps to treat

  • Primary biliary cirrhosis (PBC)
  • Gallstones (not visible on X-ray in patients with a functioning gall bladder)
  • Liver disease associated with cystic fibrosis in children aged 6 to 18 years
✔️ Pharmacology

A naturally occurring bile acid called ursodeoxycholic acid is used to treat a number of hepatobiliary conditions. The action of ursodeoxycholic acid is based on a decrease in bile cholesterol synthesis. By lowering dietary cholesterol absorption, reducing hepatic cholesterol production, and not impairing bile acid synthesis, ursodeoxycholic acid achieves this.

Bile's composition shifts from supersaturated to unsaturated as a result. Because it encourages the growth of liquid cholesterol crystal complexes, ursodeoxycholic acid also facilitates the movement of cholesterol from the gallbladder into the intestine for excretion.

  • Cholangiocytes are shielded from the cytotoxicity of hydrophobic bile acid by ursodeoxycholic acid, which aids in the treatment of cholestatic liver disease.
  • Hepatobiliary secretion stimulation
  • Bile acid does not cause apoptosis in hepatocytes.

Ursodeoxycholic acid is completely absorbed in the upper gut. Between 30 and 150 minutes pass before serum concentration reaches its maximum. The percentage of absorption varies from 60% to 80%. After absorption, ursodeoxycholic acid travels to the portal vein where it is taken up by the liver, conjugated with an amino acid (glycine or taurine), and then released into the hepatic bile ducts. Ursodeoxycholic acid is present in very small amounts in the blood and is only slightly excreted in the urine. The biological half-life of ursodeoxycholic acid ranges from 3.5 to 5.8 days.

✔️ Dosage & Administration of Ursocol 300mg Tablet

Gallstone dissolution: 8–12 mg/kg/day, given either all at once at night or in divided doses.

  • 2-4 divided doses of 10-15 mg/kg/day for primary biliary cirrhosis
  • 600 mg daily for acute viral hepatitis.
  • 300 mg/day for alcoholic fatty liver.
  • 25–30 mg/kg/day for primary sclerosing cholangiocarcinoma
  • Gallstones and Non-Alcoholic Steato Hepatitis Dissolution: 13–15 mg/kg/day.

Take Ursocol 300mg Tablet in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ursocol 300 Tablet is to be taken with food.

✔️ Interaction

Ursodeoxycholic Acid should not be used with medicines that raise bile cholesterol, such as oestrogenic hormones. Concurrent administration of Ursodeoxycholic acid with bile-acid binding medications such as antacids, charcoal, or cholestyramine should be avoided, since this may impair the efficacy of Ursodeoxycholic acid therapy.

✔️ Contraindications

Inflammatory intestinal illness, non-functioning gallbladder, calcified and pigmented gallstones

✔️ Pregnancy & Lactation

Category B pregnancy. In pregnancy, no indication of danger has been documented. It has been successfully used to treat cholestasis in pregnant women throughout the third trimester with no adverse effects. Breastfeeding problems have not been recorded in humans.

✔️ Precautions & Warnings

It is important to follow the precautions and warnings provided by the manufacturer and your healthcare provider before taking Ursocol 300mg Tablet. 

  • Ursocol 300mg Tablet should not be taken if you are allergic to any of its components or have certain medical conditions such as inflammation of the gall bladder and bile ducts, narrowing or blockage of the bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer.
  • If you have variceal bleeding, ascites, liver encephalopathy, or liver disease, you should inform your doctor before taking Ursocol 300mg Tablet.
  • It is essential to inform your doctor if you are taking any other medications, including antibiotics such as ciprofloxacin and dapsone, antihypertensive agents such as nitrendipine, immunosuppressants such as cyclosporine, oral contraceptives such as estrogen, or cholesterol-lowering agents such as clofibrate.
  • Ursocol 300mg Tablet can interact with these medications and cause unwanted side effects.
  • Ursocol 300mg Tablet should not be taken during pregnancy or while breastfeeding unless prescribed by your doctor.
  • Children above six years of age can take Ursocol 300mg Tablet only if prescribed by their doctor.
  • Consuming alcohol with Ursocol 300mg Tablet can increase the risk of drowsiness and liver damage.
  • It is important to keep your doctor informed about your health condition and medications to avoid any unpleasant side effects.
  • Your doctor may recommend frequent liver function tests to check liver function and treatment progress.
  • Ursocol 300mg Tablet may cause hair thinning and loss in rare cases; if there is considerable hair loss, visit your doctor for additional advice.
✔️ Storage Conditions

Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.

Frequently Asked Questions (FAQ)

Ursocol 300 Tablet is generally regarded as a safe and effective medication. This medication, however, may cause certain typical adverse effects, such as diarrhea. If you get diarrhea, your doctor may lower the dose, and if it persists, your therapy may be stopped. Furthermore, using this medication as a long-term therapy may have an effect on your liver enzyme levels. Your doctor will periodically evaluate your liver enzyme levels to keep an eye on this. Despite these modest adverse effects, this medication is seen to be a suitable alternative to surgery in certain gallstones patients.

Ursocol 300 Tablet works on the liver and is concentrated in bile released by the liver. As a result, the liver's production and release of cholesterol is suppressed, resulting in lower cholesterol levels in bile. This medication also prevents the intestines from absorbing bile salts and cholesterol. As a result of the lower cholesterol saturation in bile from the liver, cholesterol from gallstones gradually dissolve, resulting in a reduction in size and final disintegration. It also lowers increased liver enzyme levels by boosting bile flow through the liver, so preserving liver cells.

Avoid using an antacid preparation without first seeing your doctor, since they reduce the efficacy of Ursocol 300 Tablet. You should also avoid taking cholestyramine or colestipol since they interfere with the efficiency of Ursocol 300 Tablet. So, consult your doctor about the time interval between Ursocol 300 Tablet and these medications. Also, avoid taking oral contraceptives, estrogenic hormones, and blood cholesterol-lowering agents such as clofibrate, as these may increase the likelihood of developing gallstones and work in the opposite direction of the Ursocol 300 Tablet.

The time taken for Ursodeoxycholic Acid to show its effect is variable and depends on stone size and composition. It may start showing its effect after six to 24 months after the administration.

Depending on your health, the best time to take this medication may change. Your doctor may advise you to take 2 to 3 doses each day, with the last dosage taken at bedtime. Ursocol 300 Tablet should be taken with water or milk and with or after meals. When recommended to dissolve gallstones, it is normally advised to take it once a day at night. It should ideally be taken every 6 hours, for example, at 8 a.m., 2 p.m., and 8 p.m.

Do not stop taking Ursocol 300 Tablet unless advised by your doctor. Your doctor might advise you on how long you should continue to take Ursocol 300 Tablet. From time to time, you will need to consult your doctor to review your treatment and assess your symptoms.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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