A-Kit | Mifepristone + Misoprostol | ePharma
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A-Kit is an emergency contraceptive designed to prevent unwanted pregnancy. This pill contains synthetic progestin, which stimulates the menstrual cycle. Unwanted pregnancies can occur due to failure of contraceptives or unprotected intercourse.

Unwanted pregnancies can be stressful and can hamper a woman's health. However, it is considered better to prevent an unwanted pregnancy than going for an abortion at a later stage.


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MRP: ৳ 300 5% Off

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✅ Description:

A-Kit belongs to a category of gynecological medications known as abortifacients, utilized for terminating pregnancies 63 days from the start of the last menstrual period. It's also effective in the second trimester of pregnancy.

This kit comprises two drugs: Mifepristone and Misoprostol. Mifepristone blocks the effects of progesterone, which is necessary for sustaining a pregnancy, while Misoprostol induces contractions and cervix dilation, facilitating pregnancy expulsion. Together, they cause pregnancy termination and are administered sequentially for medical abortion.

Typically, a medical abortion requires 2-3 visits to a healthcare provider, involving medication administration and confirmation of pregnancy termination:

  • Day 1: Counseling and examination, followed by a single dose of mifepristone (200 mcg).
  • Day 2 to 3: Return to the clinic for Misoprostol (800 mcg), either orally or vaginally.
  • Day 7 to 14: Follow-up to confirm abortion completion; additional visits may be needed if abortion is incomplete.

Potential side effects include nausea, cramps, vomiting, diarrhea, infection, dizziness, and uterine bleeding, which usually resolve over time. Persistent vaginal bleeding warrants immediate medical attention. It's crucial not to abruptly stop A-Kit without consulting a doctor to avoid incomplete abortion. 

Inform your doctor of any relevant medical history, such as ectopic pregnancy, contraceptive use, breastfeeding, bleeding disorders, or heart conditions. Avoid strenuous activities to prevent excessive bleeding, and ultrasound may be used to confirm abortion completion, as lack of bleeding doesn't necessarily indicate completion.

Safety Advices


Alcohol
UNSAFE

Alcohol is known to cause excessive drowsiness and increase uterine bleeding if taken along with A-Kit.


Pregnancy
CONSULT YOUR DOCTOR

A-Kit is used for medical abortion. If taken in pregnancy, it can lead to abortion.


Breastfeeding
CONSULT YOUR DOCTOR

A-Kit should not be taken if breastfeeding as it may pass through the milk to the baby.


Driving
UNSAFE

Driving is unsafe when taking A-Kit as it might increase the risk of excessive bleeding.


Kidney
CAUTION

A-Kit is to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.


Liver
CAUTION

A-Kit to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your do

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✔️ Uses of A-Kit

Treatment of Medical Abortion

✔️ Composition of A-Kit

Each box contains 2 blister strips.

  • One strip contains 1 tablet of Mifepristone INN 200 mg.
  • Another strip contains 4 tablets of Misoprostol USP 200 microgram each.
✔️ Side Effects of A-Kit
  • Nausea
  • Uterine cramps
  • Vomiting
  • Diarrhea
  • Dizziness
  • Infection following abortion
  • Uterine bleeding
✔️ Quick Suggestions:
  • A-Kit is effective if taken within 72 hours of unprotected intercourse.
  • It's most effective when taken immediately after unprotected intercourse.
  • If vomiting occurs after taking the tablet, another one can be taken under medical supervision.
  • If menstruation is delayed three weeks after taking A-Kit, consult a doctor.
  • It does not affect fertility. Use contraception to avoid pregnancy.
✔️ For Pregnancy Termination:
  • Take it no later than 63 days after the first day of your last menstrual period.
  • Take Misoprostol 36 – 48 hours after taking Mifepristone.
  • Rest for at least 3 hours after taking the Misoprostol.
  • Take it only as prescribed by the doctor. Miscarriages, if incomplete, may result in serious medical complications leading to hospitalization, surgery, and possible infertility.
  • Vaginal bleeding lasting for approximately 12 days may occur after taking this medicine. Inform your doctor immediately if excessive bleeding occurs or if you suffer from severe abdominal pain.
✔️ Pharmacology

Mifepristone functions as a synthetic steroid with anti-progestational properties by competitively interacting with progesterone at progesterone-receptor sites. This interaction inhibits the activity of both endogenous and exogenous progesterone. Studies utilizing varied oral doses in various animal species have shown its effectiveness in Menstrual Regulation (MR) outcomes. During pregnancy, Mifepristone increases the myometrium's sensitivity to the contraction-inducing function of prostaglandins.

Misoprostol, on the other hand, is a synthetic analog of prostaglandin E1. It works by interacting with specific receptors on myometrial cells, leading to contractions of the uterus. This interaction causes a change in calcium concentration, initiating muscle contraction. Additionally, misoprostol softens the cervix and induces contractions of the uterus, facilitating the expulsion of uterine contents by interacting with prostaglandin receptors.

✔️ Dosage of A-Kit

A-Kit regimen should only be prescribed by qualified medical professionals capable of assessing embryo gestational age and diagnosing ectopic pregnancies. These professionals must also be equipped to provide surgical intervention, such as Manual Vacuum Aspiration (MVA), in cases of incomplete abortion or severe bleeding. If they cannot provide such care directly, they should have arrangements in place to ensure patient access to medical facilities capable of providing blood transfusions and resuscitation if needed.

Day 1 (First Visit): Mifepristone Administration

  • A qualified medical professional administers one tablet of Mifepristone (200 mg) orally in a single dose, typically in a clinic, medical office, or hospital setting.

Day 2 (Second Visit): Misoprostol Administration

  • 24-48 hours after taking Mifepristone, the patient self-administers four tablets of Misoprostol (800 micrograms total) buccally or sublingually.
  • The patient can place two tablets on each side of the cheek or under the tongue and should wait for 30 minutes.
  • Patients may require medication for cramps or gastrointestinal symptoms following Misoprostol administration. They should also receive instructions on managing discomfort, excessive bleeding, or other adverse reactions, along with a contact number for questions or concerns.

Day 10 to 14 (Third Visit): Post-Treatment Examination

  • Patients return to the clinic, medical office, or hospital within 10 to 14 days after taking Mifepristone for a post-treatment examination.
  • This visit is crucial for confirming the complete termination of pregnancy through clinical examination or ultrasonographic scan.

Patients with ongoing pregnancy at this visit are at risk of fetal malformation due to treatment. Surgical termination or MVA is recommended for managing treatment failures in menstrual regulation or termination of pregnancy.

✔️ Administration of A-Kit

Take A-Kit in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush, or break it. A-Kit is to be taken with food.

✔️ Interaction

A-Kit interacts with various medications, so it's important to avoid combining it with corticosteroids (such as dexamethasone), antifungals (like ketoconazole and itraconazole), antibiotics (including erythromycin and rifampicin), anti-epileptic drugs (such as phenytoin, phenobarbital, and carbamazepine), immunosuppressants (like cyclosporine, tacrolimus, and sirolimus), and medications for migraine (such as ergotamine). These interactions can lead to adverse effects and should be avoided.

In terms of food interactions, it's crucial to inform your doctor about any vitamins, herbs, or supplements you're taking, as A-Kit may interact with them, causing unwanted side effects. Additionally, A-Kit can interact with St. John's Wort, a natural remedy used for mild depression, as well as grapefruit juice.

Regarding disease interactions, caution is advised when taking A-Kit in individuals with bleeding disorders, confirmed or suspected ectopic pregnancy, heart issues, liver or kidney disease, vaginal bleeding, or porphyria, an inherited blood disorder that may cause nervous system or skin problems. It's essential to discuss any existing health conditions with your doctor before starting treatment with A-Kit.

✔️ A-Kit is contraindicated in the following cases:
  • Women with a blood clotting disorder.
  • Women experiencing abnormal vaginal bleeding.
  • Women prone to allergies.
  • Women with Porphyria.
  • Women with a liver tumor or other liver issues.
  • Women at risk of tubal pregnancy.
  • Women planning pregnancy.
  • Women with diabetes.
  • Women use anticoagulants, valproic acid, or antifungal medications.
  • Breast cancer patients.
  • Stroke patients.
✔️ Pregnancy & Lactation

During Pregnancy:

  • Mifepristone is indicated for menstrual regulation (MR) up to 63 days of pregnancy and has no other approved use during pregnancy.
  • Patients with ongoing pregnancy at the last visit are at risk of fetal malformation from treatment. Surgical termination is recommended for MR treatment failures.

During Lactation:

  • Mifepristone: It's unknown if Mifepristone is excreted in human milk, but similar hormones are. Breastfeeding women should consult their doctor to decide whether to discard breast milk for a few days after taking the medication.
  • Misoprostol: While it's not confirmed if Misoprostol is excreted in human milk, it should not be given to nursing mothers as potential excretion of misoprostol acid could lead to diarrhea in nursing infants.
✔️ Precautions
  • Avoid A-Kit if you're allergic to any of its ingredients.
  • Refrain from taking A-Kit if you have conditions like high blood pressure, high cholesterol, asthma, bleeding disorders, liver or kidney disease, blood clotting issues, or low hemoglobin levels.
  • Do not use A-Kit if you have an artificial heart valve or if you're malnourished.
  • Note that A-Kit is not an abortion pill and cannot terminate pregnancy.
  • This product is not suitable for children under 16 years of age.
✔️ Warnings:
  • There are no known side effects if A-Kit is taken with alcohol, but it's best to avoid alcohol consumption while using this product.
  • Do not use A-Kit if you're pregnant or suspect you might be. Consult a doctor before use.
  • Breastfeeding women should avoid A-Kit as it can pass into breast milk.
  • This medication may cause dizziness or fatigue, so refrain from driving if you experience these symptoms.
  • If you have a history of liver or kidney disorders, use A-Kit with caution and consult your doctor for dosage adjustments.
  • Not recommended for children under 16 years unless under medical supervision.
✔️ Safety Information:
  • Adhere to the recommended dosage.
  • Read the product label carefully before use.
  • Keep out of reach of children.
  • Use under medical supervision.
✔️ Storage Conditions:

Store in a cool & dry place. Keep out of reach of children. Do not freeze.

Frequently Asked Questions (FAQ)

No, it doesn't impair fertility. Future chances of pregnancy are unaffected.

Abdominal pain, cramping, nausea, diarrhea, dizziness, uterine contractions, pelvic pain, and shivering are common. Consult your doctor if experiencing heavy bleeding or significant discomfort.

Take Mifepristone followed by Misoprostol after 36-48 hours, as directed by your doctor in a clinical setting.

Avoid it if you have a heart fitted with an artificial valve, heart disease, asthma, blood clot or bleeding disorders, liver/kidney disease, or anemia.

Vaginal bleeding may occur, but it doesn't indicate complete abortion. Confirmation requires a doctor's examination or ultrasound.

You may experience vaginal bleeding, abdominal cramping, diarrhea, and nausea. Follow-up tests may confirm termination.

No, A-Kit should be taken as prescribed. Exceeding the dose may lead to excessive bleeding.

No, it doesn't affect future fertility. A-Kits is used for early or unwanted pregnancy termination.

A-Kit contains Mifepristone and Misoprostol. Mifepristone blocks the effect of progesterone, needed to sustain a pregnancy. Without progesterone, the uterine lining breaks down, halting pregnancy growth. Misoprostol, a prostaglandin analog, increases uterine contractions and relaxes the cervix. It's taken 24-36 hours after Mifepristone, either orally or vaginally.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.

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