A-Kit is an emergency contraceptive designed to prevent unwanted pregnancy. This pill contains synthetic progestin, which stimulates the menstrual cycle. Unwanted pregnancies can occur due to failure of contraceptives or unprotected intercourse.
Unwanted pregnancies can be stressful and can hamper a woman's health. However, it is considered better to prevent an unwanted pregnancy than going for an abortion at a later stage.
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A-Kit belongs to a category of gynecological medications known as abortifacients, utilized for terminating pregnancies 63 days from the start of the last menstrual period. It's also effective in the second trimester of pregnancy.
This kit comprises two drugs: Mifepristone and Misoprostol. Mifepristone blocks the effects of progesterone, which is necessary for sustaining a pregnancy, while Misoprostol induces contractions and cervix dilation, facilitating pregnancy expulsion. Together, they cause pregnancy termination and are administered sequentially for medical abortion.
Typically, a medical abortion requires 2-3 visits to a healthcare provider, involving medication administration and confirmation of pregnancy termination:
Potential side effects include nausea, cramps, vomiting, diarrhea, infection, dizziness, and uterine bleeding, which usually resolve over time. Persistent vaginal bleeding warrants immediate medical attention. It's crucial not to abruptly stop A-Kit without consulting a doctor to avoid incomplete abortion.
Inform your doctor of any relevant medical history, such as ectopic pregnancy, contraceptive use, breastfeeding, bleeding disorders, or heart conditions. Avoid strenuous activities to prevent excessive bleeding, and ultrasound may be used to confirm abortion completion, as lack of bleeding doesn't necessarily indicate completion.
Alcohol is known to cause excessive drowsiness and increase uterine bleeding if taken along with A-Kit.
A-Kit is used for medical abortion. If taken in pregnancy, it can lead to abortion.
A-Kit should not be taken if breastfeeding as it may pass through the milk to the baby.
Driving is unsafe when taking A-Kit as it might increase the risk of excessive bleeding.
A-Kit is to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.
A-Kit to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your do
Treatment of Medical Abortion
Each box contains 2 blister strips.
Mifepristone functions as a synthetic steroid with anti-progestational properties by competitively interacting with progesterone at progesterone-receptor sites. This interaction inhibits the activity of both endogenous and exogenous progesterone. Studies utilizing varied oral doses in various animal species have shown its effectiveness in Menstrual Regulation (MR) outcomes. During pregnancy, Mifepristone increases the myometrium's sensitivity to the contraction-inducing function of prostaglandins.
Misoprostol, on the other hand, is a synthetic analog of prostaglandin E1. It works by interacting with specific receptors on myometrial cells, leading to contractions of the uterus. This interaction causes a change in calcium concentration, initiating muscle contraction. Additionally, misoprostol softens the cervix and induces contractions of the uterus, facilitating the expulsion of uterine contents by interacting with prostaglandin receptors.
A-Kit regimen should only be prescribed by qualified medical professionals capable of assessing embryo gestational age and diagnosing ectopic pregnancies. These professionals must also be equipped to provide surgical intervention, such as Manual Vacuum Aspiration (MVA), in cases of incomplete abortion or severe bleeding. If they cannot provide such care directly, they should have arrangements in place to ensure patient access to medical facilities capable of providing blood transfusions and resuscitation if needed.
Day 1 (First Visit): Mifepristone Administration
Day 2 (Second Visit): Misoprostol Administration
Day 10 to 14 (Third Visit): Post-Treatment Examination
Patients with ongoing pregnancy at this visit are at risk of fetal malformation due to treatment. Surgical termination or MVA is recommended for managing treatment failures in menstrual regulation or termination of pregnancy.
Take A-Kit in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush, or break it. A-Kit is to be taken with food.
A-Kit interacts with various medications, so it's important to avoid combining it with corticosteroids (such as dexamethasone), antifungals (like ketoconazole and itraconazole), antibiotics (including erythromycin and rifampicin), anti-epileptic drugs (such as phenytoin, phenobarbital, and carbamazepine), immunosuppressants (like cyclosporine, tacrolimus, and sirolimus), and medications for migraine (such as ergotamine). These interactions can lead to adverse effects and should be avoided.
In terms of food interactions, it's crucial to inform your doctor about any vitamins, herbs, or supplements you're taking, as A-Kit may interact with them, causing unwanted side effects. Additionally, A-Kit can interact with St. John's Wort, a natural remedy used for mild depression, as well as grapefruit juice.
Regarding disease interactions, caution is advised when taking A-Kit in individuals with bleeding disorders, confirmed or suspected ectopic pregnancy, heart issues, liver or kidney disease, vaginal bleeding, or porphyria, an inherited blood disorder that may cause nervous system or skin problems. It's essential to discuss any existing health conditions with your doctor before starting treatment with A-Kit.
During Pregnancy:
During Lactation:
Store in a cool & dry place. Keep out of reach of children. Do not freeze.
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