Quiet 200 XR Tablet 10pcs

Uses of Quiet 200 XR Tablet

• Treatment of Mania
• Treatment of Schizophrenia

How does Quiet 200 XR Tablet work?

Quetiapine works by inhibiting the release of certain chemical substances in the brain which are responsible for causing anxiety and the symptoms of schizophrenia.

Overdose of Quiet 200 XR Tablet

• Survival reported in overdoses up to 30 grams.
• No specific antidote; consider intensive care measures.
• Treat refractory hypotension with intravenous fluids and/or sympathomimetic agents (avoid adrenaline and dopamine).

Special Populations:

• Elderly: Use with caution, slower dose titration, and lower daily dose.
• Children and Adolescents: Not indicated for use below 18 years.

Side Effects of Quiet 200 XR Tablet

• Dizziness, weakness, drowsiness
• Withdrawal symptoms (nausea, vomiting, diarrhea, irritability)
• Low blood pressure
• Rapid heartbeat
• Fainting
• Seizures
• Symptoms of neuroleptic malignant syndrome (high fever, muscle stiffness, confusion)
• Nightmares, unpleasant dreams, suicidal thoughts
• Worsening symptoms (anxiety, panic attacks, irritability, agitation, aggressiveness)
• Weight gain, increased appetite
• Changes in blood levels (e.g., elevated blood sugar, elevated liver enzymes)
• Metabolic syndrome (increase in abdominal fat, decreased HDL cholesterol, high blood pressure, elevated blood glucose, elevated triglycerides)
• Difficulty passing urine
• Nausea, vomiting, diarrhea
• Blurred vision, difficulty speaking
• Swelling of hands and legs
• Stuffy nose
• Allergic reactions (itching, hives, rash, swelling of lips, face, throat)
• Liver issues (jaundice, liver disease)
• Formation of blood clots
• Restless legs syndrome
• Low body temperature (hypothermia)

Quetiapine is used to treat various mental health conditions, including:

1. Schizophrenia: A mental disorder that affects a person’s ability to think, feel, and behave clearly.
2. Bipolar Disorder: A condition characterized by mood swings that include emotional highs (mania or hypomania) and lows (depression).
   • Manic Episodes: Periods of abnormally elevated mood and energy levels.
   • Depressive Episodes: Periods of intense sadness or despair.
3. Major Depressive Disorder (MDD): Used as an adjunct treatment for patients not responding to standard antidepressants.
4. Prevention of Recurrence: Helps in preventing recurrence of depressive episodes in bipolar disorder.

Pharmacology

Quetiapine Fumarate is an atypical psychotropic agent belonging to the dibenzothiazepine derivatives. It acts as an antagonist at multiple neurotransmitter receptors, including serotonin 5HT1A and 5HT2, dopamine D1 and D2, histamine H1, and adrenergic α1 and α2 receptors. It has no appreciable affinity for cholinergic muscarinic and benzodiazepine receptors. The efficacy in schizophrenia is believed to be mediated through dopamine D2 and serotonin 5HT2 antagonism. Its antagonism of histamine H1 receptors may explain somnolence, and adrenergic α1 receptor antagonism may explain orthostatic hypotension.

Schizophrenia:

• Administer twice daily, with or without food.
• Day 1: 50 mg, Day 2: 100 mg, Day 3: 200 mg, Day 4: 300 mg.
• The usual effective dose range: is 300-450 mg/day, adjustable within 150-750 mg/day based on response and tolerability.

Manic episodes in bipolar disorder:

• Administer twice daily, with or without food.
• Day 1: 100 mg, Day 2: 200 mg, Day 3: 300 mg, Day 4: 400 mg.
• Dosage adjustments up to 800 mg/day by Day 6 in increments no greater than 200 mg/day.
• Effective dose range: 400-800 mg/day.

Depressive episodes in bipolar disorder:

• Administer once daily at bedtime, with or without food.
• Day 1: 50 mg, Day 2: 100 mg, Day 3: 200 mg, Day 4: 300 mg.
• Can be titrated to 400 mg on Day 5 and up to 600 mg by Day 8.
• Effective dose range: 300-600 mg/day.

Maintenance in bipolar I disorder:

• Continue the same dose as in acute treatment with a mood stabilizer.
• The dose can be adjusted based on response and tolerability.
• Effective combination therapy dose: 400-800 mg/day.

Directions for Use:

Take Quiet 200 XR Tablet as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Quiet 200 XR Tablet should be taken at least one hour before meals or before bedtime.

Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Do not stop taking the Quiet 200 XR Tablet unless your doctor advises you to stop, as it may lead to certain withdrawal symptoms such as difficulty in sleeping, nausea, diarrhea, vomiting, irritability, weight gain, or increased hunger.

Missed Dose & Overdose

Do not miss the dose of Quetiapine. In case you miss a dose, take it as soon as you remember. However, if it is time for the next dose, then skip the missed dose. Do not double the dose to make up for the missed one.

Do not take more than the prescribed dose of Quetiapine. Seek emergency medical treatment in case of an overdose.

Interaction

1. Drug Interactions: Avoid Quetiapine if you are taking:
   • Protease inhibitors for HIV (e.g., Atazanavir, Lopinavir).
   • Antifungal medications (e.g., Ketoconazole, Posaconazole, Itraconazole).
   • Certain antibiotics (e.g., Erythromycin, Clarithromycin).
   • Nefazodone, is used for depression.

Quetiapine should not be used in the following situations:

Allergy: If you are allergic to Quetiapine or any of its components.

Pregnancy & Lactation

• Safety during pregnancy is not established. Use only if benefits justify potential risks.
• Unknown if excreted in human milk; avoid breastfeeding.

Precautions & Warnings

• Pregnancy & Lactation:
• Cardiovascular Disease
• Elderly
• Children and Adolescents

Storage Conditions:

• Store in a cool, dry place away from light. Keep out of reach of children. Do not use after the expiry date.