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Flurizin 5mg Tablet 1 Strip
Flunarizine, the active ingredient in Flurizin, is a selective calcium channel blocker and a difluorinated derivative of cinnarizine. It works by reducing excessive calcium influx into cells, preventing calcium overload while maintaining normal calcium homeostasis. Flunarizine also exhibits antihistaminic and sedative properties. It binds extensively to plasma proteins (99%).
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✅ Description:
Flurizin is prescribed for:
- Migraine prevention, including both classic migraines (with aura) and common migraines (without aura).
- Vestibular vertigo, when caused by a diagnosed functional disorder of the vestibular system.
- Peripheral Vascular Disease (PVD).
- Motion sickness.
- Refractory epilepsy, which does not respond to conventional antiepileptic treatment.
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✔️ Uses of Flurizin 5
- Manage migraine
✔️ How does Flurizin 5 work?
eFlurizin 5ffectively helps in the management of migraine by managing of narrowing of blood vessels.
✔️ Dosage & Administration of Flurizin 5
Migraine Prevention:
Starting Dose:
- Adults (<65 years): 10 mg at bedtime.
- Elderly (>65 years): 5 mg daily.
If depressive, extrapyramidal, or other serious side effects occur, discontinue use.
If no improvement is seen after two months, treatment should be stopped.
Maintenance Dose:
- If effective, reduce the dose to five days per week (same daily dose), with two drug-free days.
- If treatment remains effective for six months, discontinue use; restart only if symptoms return.
Peripheral Vascular Disease (PVD):
- 10 mg twice daily, increasing to 30 mg per day if needed.
Vertigo & Motion Sickness:
- Adults: 10-20 mg daily.
- Children (>40 kg): 5 mg daily.
Epileptic Seizures (as adjunct therapy):
- Adults: 15-20 mg daily.
- Children: 5-10 mg daily.
✔️ Side Effects of Flurizin 5
Common side effects may include:
- Drowsiness or fatigue.
- Increased appetite and weight gain.
- Long-term use may lead to:
- Depression, particularly in women with a prior history.
- Extrapyramidal symptoms, such as:
- Bradykinesia (slow movements)
- Rigidity
- Akathisia (restlessness)
- Orofacial dyskinesia (involuntary facial movements)
- Tremors (especially in elderly patients)
- Other infrequent side effects:
- Heartburn, nausea, stomach pain
- Insomnia, anxiety
- Galactorrhoea (milk secretion without pregnancy)
- Dry mouth, muscle pain
- Skin rash
✔️ Drug Interactions
- Some women on oral contraceptives may experience galactorrhoea (unexpected milk production) within the first two months of treatment.
- Carbamazepine and Phenytoin (hepatic enzyme inducers) may increase the metabolism of Flurizin, requiring a higher dosage adjustment.
✔️ Flurizin should not be used in:
- Patients are allergic to Flunarizine.
- Individuals with a history of depression.
- Patients with Parkinson’s disease or other extrapyramidal disorders.
✔️ Pregnancy & Lactation
The safety of Flurizin during pregnancy and breastfeeding has not been established. Consult a doctor before use.
✔️ Precautions & Warnings
Flurizin may cause drowsiness, which can be worsened by alcohol or sedatives. Avoid activities that require mental alertness, such as driving or operating heavy machinery.
This medication is not intended to stop an ongoing migraine attack. Do not increase the dose if an attack occurs.
It may cause extrapyramidal symptoms and depression, potentially triggering Parkinsonism, particularly in elderly or predisposed patients. Use with caution.
✔️ Storage Instructions
Store below 30°C, away from light and moisture.
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