Migrex 200mg Tablet 10pcs

Uses of Migrex 200

• Treat mild to moderate pain, and acute migraine attacks.

How does Migrex 200 work?

Migrex 200 is a non-steroidal anti-inflammatory drug (NSAID) that blocks the release of certain chemical messengers responsible for fever, pain, and inflammation.

Side Effects of Migrex 200

Common side effects include diarrhea, nausea, vomiting, dyspepsia, headache, tremor, euphoria, fatigue, pulmonary infiltration, and hematuria, especially in males. Blood dyscrasias and hepatitis are rare but serious.

Quick Suggestions:

• Take Migrex 200 with food or milk to prevent stomach upset.
• Long-term use of Migrex 200 can lead to serious complications like stomach bleeding and kidney problems.
• Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
• Inform your doctor about any history of kidney or liver problems.

Indications:

Tolfenamic acid is indicated for the treatment of migraine headaches and as an analgesic for post-operative pain and fever.

Pharmacology

Tolfenamic acid, also known as N-(2-methyl-3-chlorophenyl) anthranilic acid, belongs to the fenamate class. It inhibits the production of inflammatory mediators like thromboxane (TX) B2 and prostaglandin (PG) E2, which are responsible for swelling, pain, and inflammation. It acts by directly antagonizing receptors and reducing prostaglandin synthesis.

Dosage & Administration of Migrex 200

For adults, the dosage for acute migraine attacks is 200 mg at symptom onset, with a possible repeat dose after 1-2 hours. For mild to moderate pain, the dose ranges from 100-200 mg three times daily. Adjustments may be necessary for renal impairment, while severe impairment warrants avoidance. There's no established pediatric dosage regimen. Tolfenamic acid should be taken with food and accompanied by water during or after meals.

Interaction

Metoclopramide and magnesium hydroxide increase tolfenamic acid absorption, while aluminum hydroxide decreases it. Concurrent use with anticoagulants and other NSAIDs increases bleeding risk. It reduces the antihypertensive effects of loop diuretics, beta-blockers, and ACE inhibitors. Co-administration elevates blood levels of lithium, methotrexate, and cardiac glycosides. When combined with ACE inhibitors, ciclosporin, tacrolimus, or diuretics, there's an increased risk of nephrotoxicity.

Contraindications

Tolfenamic acid is contraindicated in active or bleeding peptic ulcers, and severe heart, kidney, or liver failure.

Pregnancy & Lactation

Avoid use during pregnancy, particularly in the third trimester, unless deemed necessary. NSAIDs may be present in breast milk at low levels, so caution is advised during breastfeeding.

Precautions & Warnings

Exercise caution in patients with asthma, bronchospasm, blood disorders, cardiovascular diseases, peptic ulcers, hypertension, liver infection, or renal/cardiac impairment. Increased water intake or dose reduction may minimize dysuria.

Storage Conditions:

Store in a cool, dry place away from light, and keep out of reach of children.