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✅ Description:
Indication
A medication called Tigover 5 is used to stop migraines in their tracks. It only works to prevent migraines for as long as you take the medication; it cannot, however, treat an acute attack. This medication reduces mental tension, hence reducing migraines.
Pharmacology
Flunarizine is a selective calcium antagonist. It prevents cellular calcium overload by reducing excessive transmembrane calcium inuxes. Flunarizine does not interfere with normal cellular calcium homeostasis. Flunarizine also has antihistaminic properties. The e‑ects of Flunarizine in the prophylaxis of migraine are most pronounced with regard to the reduction of the frequency of attacks.
Dosage & Administration
Migraine Prophylaxis
Starting Dose: 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years. If, after 2 months of this initial treatment, no significant improvement is observed, the patient should be considered a non-responder and administration should be discontinued.
Maintenance Treatment: If a patient is responding satisfactorily and if maintenance treatment is needed, the dose should be decreased to 5 days of treatment at the same daily dose with two successive medicine-free days every week. Even if the prophylactic maintenance treatment is successful and well tolerated, it should be interrupted after 6 months and it should be re-initiated only if the patient relapses.
Vertigo: The same dosage should be used as for migraine, but the starting treatment should not be given longer than needed for symptom control, which generally takes less than two months.
Interaction
Galactorrhoea has been detailed in a few ladies on verbal contraceptives inside the primary two months of Flunarizine treatment. Hepatic protein inducers such as Carbamazepine and Phenytoin may connect with flunarizine by expanding its digestion system. So an increment in the dose of flunarizine may be required.
Contraindications
Hypersensitivity to Flunarizine. Flunarizine is contra-indicated in patients with a history of depressive illness, or with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders.
Side effects
- Sleepiness
- Weight gain
- Muscle pain
- Fatigue
- Constipation
- Nausea
- Insomnia (difficulty in sleeping)
- Runny nose
- Increased appetite
- Depression
- Stomach discomfort
- Breast pain
Pregnancy and lactation
Safety in pregnancy and lactation has not been established.
Precaution and Warning
Flunarizine may lead to drowsiness which is aggravated by the simultaneous intake of alcohol or other central nervous system depressants. This treatment may give rise to extrapyramidal and depressive symptoms and reveal Parkinsonism, especially in predisposed patients such as the elderly.
Storage Conditions
Store below 30°C. Keep the medicine out of the reach of children
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