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Tablet Manufacturer/Distributor: Aristopharma Limited Generic Name: Pizotifen 1.5 mg Tablet
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✅ Description:
Indications
Pizotifen is used to treat vascular headaches of the migraine type, such as classical migraine, common migraine, and cluster headache, as a preventative measure. It is ineffective in stopping migraine attacks after they have started.
Pharmacology
Pizotifen works by hindering the fringe activities of serotonin and histamine in expanding the layer porousness of cranial vessels and transudation of plasma kinin, whereas changing torment edges in headaches. By blocking 5-HT receptors, pizotifen weakens the flagging of serotonin in causing cranial vasoconstriction, as well as serotonin-enhanced platelet work and accumulation. There's proof that it moreover represses the fringe activities of bradykinin. Pizotifen may repress serotonin reuptake by blood platelets, which influences the tonicity and diminishes detached distension of extracranial supply routes. The impacts of pizotifen driving to craving incitement may be due to the sedate acting at the metabolic level instead of a coordinate incitement of the craving middle.
Dosage & Administration
Grown-ups: More often than not 1.5 mg day by day. This may be taken as a single measurement at night or in three separated measurements. Measurement ought to be balanced to the person persistent necessities up to a most extreme of 4.5 mg day by day. Up to 3 mg may be given as a single dose.
Children (above the age of 2): Up to 1.5 mg daily, divided into two doses, though up to 1 mg has been given as a single dose at night.
Interaction
The central impacts of tranquilizers, hypnotics, antihistamines (counting certain common cold arrangements) and liquor may be improved by Pizotifen. Pizotifen antagonizes the hypotensive impact of adrenergic neurone blockers.
Contraindications
Patients who have a known hypersensitivity to any of the components in pizotifen should not use it.
Side Effect
The most common side effects are appetite stimulating effect, increase in body weight and drowsiness.
Pregnancy & Lactation
Information of using Pizotifen in pregnancy is limited, although no ill effects have been reported. The drug should therefore only be given during pregnancy if the potential benefit to mother justifies the potential risk to the fetus. The safety of Pizotifen during lactation has not been established, so mothers should avoid taking it when breastfeeding.
Precautions & Warnings
Renal impairment and urinary retention should be considered. Drowsiness can impair your ability to drive a car or operate machinery. Pizotifen boosts the effects of alcohol.
Storage Conditions
Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.
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