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Lioresal 25mg Tablet 10pcs
Baclofen 25mg Tablet is used to reduce and relieve the excessive tension in your muscles (spasms) associated with various conditions such as cerebral palsy (a group of disorders that affect movement, balance, and muscle tone or posture), multiple sclerosis (a condition that occurs when the immune system attacks the nerve fibers in the central nervous system and damages them), spinal cord injury/diseases, and other nervous system disorders.
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✅ Description:
- Treatment of spasticity, including flexor spasms, associated pain, clonus, and muscular rigidity.
- Conditions such as multiple sclerosis, rheumatic disorders, spinal cord injuries, spinal cord diseases, cerebrovascular accidents, and brain diseases (neoplastic or degenerative).
- Lioresal 25mg Tablet may be taken with food to avoid stomach irritation. Take it at the same time every day to maintain a constant level of this medicine in your body. Do not stop taking this medicine without consulting your doctor, as it may cause withdrawal symptoms.
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✔️ Side Effects of Lioresal 25mg Tablet
- Common: Drowsiness, dizziness, weakness, fatigue.
- Serious: Headaches, insomnia, euphoria, depression, confusion, hallucinations, muscle pain, visual disturbances, seizures, respiratory depression.
- Cardiovascular: Hypotension, dyspnea, palpitations, chest pain, syncope.
- Gastrointestinal: Nausea, constipation, dry mouth, abdominal pain, vomiting, diarrhea.
- Genitourinary: Urinary frequency, retention, dysuria, impotence, nocturia.
- Other: Rash, weight gain, nasal congestion, hepatic function disorders.
✔️ Uses:
Spasticity
✔️ Mode of Action:
- Inhibits monosynaptic and polysynaptic reflexes at the spinal level by stimulating GABAB receptors, reducing the release of glutamate and aspartate. It may also cause CNS depression and exhibit an antinociceptive effect.
✔️ How Lioresal 25mg Tabletworks
Lioresal 25mg Tablet works by inhibiting the release of certain chemicals in the brain and spinal cord, which helps to relieve pain and improve muscle movement.
✔️ Overdose Effects of Lioresal 25mg Tablet
- Severe overdose may require gastric lavage.
✔️ Pharmacology:
- Lioresal 25 mg acts as a muscle relaxant and antispastic agent, mainly at the spinal level.
- Though its exact mechanism is unclear, it works by stimulating GABAB receptors, inhibiting the release of glutamate and aspartate, and affecting both monosynaptic and polysynaptic reflexes.
- It may also depress the central nervous system (CNS) at intraspinal sites without impacting neuromuscular transmission.
- Exhibits an antinociceptive (pain-relieving) effect, though the clinical relevance is uncertain.
✔️ Dosage & Administration of Lioresal 25mg Tablet
- Adults: Typically divided doses, three times a day, starting low and increasing gradually. Usual range: 30-80 mg daily; maximum: 80 mg daily.
- Children: Start with very low doses (0.3 mg/kg per day, divided) and increase cautiously. Maintenance dose: 0.75 to 2 mg/kg per day. For children over 10 years, maximum: 2.5 mg/kg per day.
- Take with a small amount of liquid during meals.
✔️ Interactions:
- Increased sedation with CNS depressants, alcohol, synthetic opiates, and risk of respiratory depression.
- Enhanced hypotension with antihypertensives; dosage adjustment may be needed.
- Increased muscle hypotonia with tricyclic antidepressants.
- Potential mental confusion, hallucinations, and other symptoms in Parkinson’s disease patients using levodopa and carbidopa.
- Increased CNS depressant effects with MAO inhibitors.
- Possible synergistic effect with magnesium sulfate or other neuromuscular blocking agents.
✔️ Contraindications:
- Hypersensitivity to any component of Lioresal 25 mg.
✔️ Pregnancy & Lactation:
- Category B3. Crosses the placental barrier; use only if benefits outweigh risks. Excreted in breast milk in minimal amounts, unlikely to affect the infant.
✔️ Precautions & Warnings:
- Lower doses for patients with renal impairment or undergoing hemodialysis.
- Monitor patients with psychiatric disorders, epilepsy, peptic ulcers, cerebrovascular diseases, or hepatic/renal/respiratory failure.
- Not significantly beneficial for stroke patients; poor tolerance observed.
- Regular tests for hepatic diseases or diabetes mellitus.
✔️ Storage Conditions:
- Store below 30°C, away from light and moisture. Keep out of reach of children.
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