Sirdalud 2mg 10pcs - ePharma
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Sirdalud 2mg 10pcs

Generic: Tizanidine 2 mg

Type: Tablet

Pack Size: 10 Pcs

Tablet Manufacturer/Distributor: Novartis (Bangladesh) Ltd. Generic Name: Tizanidine 2 mg Tablet


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Discount Price: ৳ 109.54
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✅ Description:

Indications

Treatment of painful muscle spasms:

Associated with static and functional disorders of the spine (cervical and lumbar syndromes).

Following surgery, e.g. for herniated intervertebral disc or osteoarthritis of the hip.

Treatment of spasticity due to neurological disorders:

Multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases, cerebrovascular accidents, and cerebral palsy.

 

Pharmacology

Tizanidine may be a centrally acting skeletal muscle relaxant. Its foremost location of activity is the spinal rope, where the prove proposes that, by fortifying presynaptic alpha2 receptors, it represses the discharge of excitatory amino acids that fortify N-methyl-D aspartate (NMDA) receptors. Polysynaptic flag transmission at spinal interneuron level, which is mindful for intemperate muscle tone, is hence restrained and muscle tone decreased. In expansion to its muscle-relaxant properties, tizanidine too applies a direct central pain relieving effect.

Pharmacodynamic: Tizanidine is successful in both intense excruciating muscle fits and persistent spasticity of spinal and cerebral beginning. It decreases resistance to detached developments, eases fits and clonus, and may progress deliberate quality. The antispastic movement (measured by the Ashworth score and pendulum test) and antagonistic impacts (heart rate and blood weight) of Tizanidine are related to plasma tizanidine concentrations.

 

Dosage & Administration

Tizanidine has a narrow therapeutic index and high inter-patient variability in tizanidine plasma concentrations which requires individualized dose adjustment. A low starting dose of 2 mg three times daily can minimize the risk for adverse effects. The dose should be carefully adjusted upward according to the needs of the individual patient.

Relief of painful muscle spasms: The usual dose is 2 to 4 mg three times daily in tablet form. In severe cases, an extra dose of 2 or 4 mg may be taken, preferably at night to minimize sedation.

Spasticity due to neurological disorders: The initial daily dose should not exceed 6 mg given in 3 divided doses. It may be increased stepwise at half-weekly or weekly intervals by 2 to 4 mg. The optimum therapeutic response is generally achieved with a daily dose of between 12 and 24 mg, administered in 3 or 4 equally spaced doses. The daily dose of 36 mg should not be exceeded.

Pediatrics patients: Experience in patients below 18 years of age is limited and the use of Tizanidine in this population is not recommended.

Geriatric patients (65 years of age or older): Experience with the use of Tizanidine in the elderly is limited. Therefore, it is recommended to start treatment at the lowest dose and increases should be done in small steps according to tolerability and efficacy.

Renal impairment: In patients with renal impairment (creatinine clearance <25 mL/min), it is recommended to start treatment at 2 mg once daily. An increase in dosage should be done in small steps according to tolerability and efficacy. If efficacy has to be improved, it is advisable to first increase the strength of the daily dose before increasing the frequency of administration.

 

Interaction

Concomitant administration of drugs known to inhibit the activity of CYP1A2 may increase the plasma levels of tizanidine. The increased plasma levels of tizanidine may result in overdose symptoms such as QT(c) prolongation. Concomitant administration of drugs known to induce the activity of CYP1A2 may decrease the plasma levels of tizanidine. The decreased plasma levels of tizanidine may reduce the therapeutic effect of Tizanidine.

Observed interactions resulting in a contraindication: Concomitant use of Tizanidine with fluvoxamine or ciprofloxacin, both CYP1A2 inhibitors is contraindicated. Concomitant use of Tizanidine with fluvoxamine or ciprofloxacin resulted in a 33-fold and 10-fold increase in tizanldine AUC, respectively. Clinically significant and prolonged hypotension may result along with somnolence, dizziness and decreased psychomotor performance. The increased plasma levels of tizanidine may result in overdose symptoms such as QT(c) prolongation.

Watched intuitive to be considered: Caution ought to be worked out when Tizanidine is given with drugs known to draw out the QT interim (counting but not restricted to cisapride, amytriptyline and azithromycin).

Antihypertensives: Concomitant utilize of Tizanidine with antihypertensives, counting diuretics, may sometimes cause hypotension and bradycardia. In a few patients bounce back hypertension and tachycardia have been watched upon sudden cessation of Tizanidine when concomitantly utilized with antihypertensive drugs. In extraordinary cases, bounce back hypertension might lead to cerebrovascular accident.

Rifampicin: Concomitant organization of Tizanidine with rifampicin comes about in 50% diminish in tizanidine concentrations. In this manner, the restorative impacts of Tizanidine may be decreased amid treatment with rifampicin, which may be of clinical importance in a few patients.

Liquor: Whereas on Tizanidine treatment, liquor utilization ought to be minimized or maintained a strategic distance from because it may increment the potential for unfavorable occasions (e.g. sedation and hypotension). The central apprehensive framework depressant impacts of liquor may be upgraded by Tizanidine.

Anticipated intelligent to be considered: Narcotics, hypnotics (e.g. benzodiazepine or baclofen), and another sedate such as antihistamines may improve the narcotic activity of tizanidine. Tizanidine ought to be dodged when utilizing with other alpha-2 adrenergic agonists (such as clonidine) since of their potential added substance hypotensive impact.

 

Contraindications

Known hypersensitivity to tizanidine or to any of the excipients.

Severely impaired hepatic function.

Concomitant use of tizanidine with strong inhibitors of CYP1A2 such as fluvoxamine or ciprofloxacin is contraindicated.

 

Side Effects

With moo dosages, such as those prescribed for the alleviation of difficult muscle fits, drowsiness, weakness, discombobulation, dry mouth, blood weight diminish, queasiness, gastrointestinal clutter and transaminase increment have been detailed, as a rule as mellow and temporal antagonistic reactions.

With the higher measurements suggested for the treatment of spasticity, the antagonistic responses detailed with moo dosages are more visit and more articulated, but at times extreme sufficient to require cessation of treatment. In expansion, the taking after unfavorable responses may happen: hypotension, bradycardia, solid shortcoming, sleep deprivation, rest clutter, mental trip & hepatitis.

Psychiatric disarranges: Common- A sleeping disorder, rest disorder. Nervous framework clutters: Exceptionally common- Lethargy, dizziness.

Cardiac clutters: Exceptional- Bradycardia.

Vascular disarranges: Common- Hypotension.

Gastrointestinal disarranges: Exceptionally common- Gastrointestinal clutter, dry mouth; Common- Nausea.

Musculoskeletal and connective tissue disarranges: Exceptionally common- Solid weakness

General clutters and organization location conditions: Exceptionally common- Fatigue.

Investigations: Common- Blood weight diminished, transaminases expanded.

 

Pregnancy & Lactation

As there's restricted involvement with the utilize of Tizanidine in pregnant ladies, it ought to not be utilized amid pregnancy unless the advantage clearly exceeds the risk.

Animal information: Generation thinks about performed in rats and rabbits did not appear prove of teratogenicity. In rats, dosage levels of 10 and 30 mg/kg/day expanded incubation length. Pre-birth and postnatal pup misfortune was expanded and advancement impediment happened. At these measurements, dams appeared stamped signs of muscle unwinding and sedation. Based on body surface range, these dosages were 2.2 and 6.7 times the greatest suggested human dosage of 0.72 mg/kg/day.

Lactation: Little sums of tizanidine are excreted in rodent drain. Since no human (fata are accessible Tizanidine ought to not be given to ladies who are breast-feeding.

Females and guys of regenerative potential: Pregnancy testing: Sexually-active females of regenerative potential are prescribed to have a pregnancy test earlier to beginning treatment with Tizanidine.

Contraception: Females of regenerative potential ought to be prompted that creature considers have been performed appearing Tizanidine to be hurtful to the creating baby. Sexually-active females of regenerative potential are suggested to utilize compelling contraception (strategies that result in less than 1 % pregnancy rates) when utilizing Tizanidine amid treatment and for 1 day after halting treatment with Tizanidine.

Fertility: Creature information: No disability of richness was watched in male rats at a dosage of 10 mg/kg/day, and in female rats at a dosage of 3 mg/kg/day.

 

Precautions & Warnings

CYP inhibitors: The concomitant use of Tizanidine with moderate CYP1A2 inhibitors is not recommended. Caution should be exercised when Tizanidine is given with drugs known to increase the QT interval.

Hypotension: Hypotension may occur during treatment with Tizanidine and also as a result of drug interactions with CYP1A2 inhibitors and/or antihypertensive drugs. Severe manifestations of hypotension such as loss of consciousness and circulatory collapse have also been observed.

Withdrawal syndrome: Rebound hypertension and tachycardia have been observed after sudden withdrawal of Tizanidine, when it had been used chronically, and/or in high daily dosages, and/or concomitantly with antihypertensive drugs. In extreme cases, rebound hypertension might lead to cerebrovascular accident. Tizanidine should not be stopped abruptly, but rather gradually down titrated.

Hepatic dysfunction: Since hepatic dysfunction has been reported in association with tizanidine, but rarely at daily doses up to 12 mg, it is recommended that liver function tests should be monitored monthly for the first four months in patients receiving doses of 12 mg and higher and in patients who develop clinical symptoms suggestive of hepatic dysfunction, such as unexplained nausea, anorexia or tiredness. Treatment with Tizanidine should be discontinued if serum levels of SGPT or SGOT are persistently above three times the upper limit of the normal range.

Patients with renal impairment: In patients with renal impairment (creatinine clearance <25 mL/min) systemic exposure to tizanidine may increase up to 6 times compared to patient with normal renal function. Therefore, it is recommended to start treatment at 2 mg once daily.

Hypersensitivity reactions: Hypersensitivity reactions including anaphylaxis, angioedema, dermatitis, rash, urticarial, pruritis and erythema have been reported in association with tizanidine. Careful observation of the patient is recommended for one to two days after the first dose is administered. If anaphylaxis or angioedema with anaphylactic shock or difficulty of breathing is observed treatment with Tizanidine should be discontinued immediately and appropriate medical treatment should be instituted.

Driving and using machines: Patients experiencing somnolence, dizziness or any signs or symptoms of hypotension should refrain from activities requiring a high degree of alertness, e.g. driving a vehicle or operating machines.

Storage Conditions

Store in a cool, dry location away from light and moisture. If maintained at room temperature, the reconstituted suspension must be used within 7 days; if kept in the refrigerator, it must be used within 14 days. Keep out of children's reach.

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