Fluticasone Furoate, the active ingredient in Avamist, is a synthetic corticosteroid that binds to glucocorticoid receptors, providing anti-inflammatory activity. It inhibits the migration of inflammatory mediators and cells involved in inflammation, such as histamine, leukotrienes, mast cells, and eosinophils, among others.
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Seasonal allergies, also known as hay fever or allergic rhinitis, occur when the immune system overreacts to allergens present in the air during specific seasons of the year. These allergens, such as pollen from trees, grasses, and weeds, trigger allergic reactions in susceptible individuals. Seasonal allergies typically cause symptoms such as:
Perennial allergies, on the other hand, occur year-round and are typically triggered by indoor allergens present in the environment regardless of the season. Common indoor allergens include dust mites, pet dander, mold spores, and cockroach droppings. Symptoms of perennial allergies may include:
Perennial nonallergic rhinitis, also known as vasomotor rhinitis, shares symptoms with allergic rhinitis but is not triggered by allergens. Instead, it is characterized by chronic inflammation of the nasal passages, leading to symptoms such as nasal congestion, runny nose, sneezing, and nasal itching. Unlike allergic rhinitis, perennial nonallergic rhinitis occurs year-round and is not associated with specific allergens.
Overall, the distinction between seasonal, perennial allergic, and perennial nonallergic rhinitis lies in the triggers of the condition and the duration of symptoms. While seasonal allergies occur during specific seasons due to exposure to outdoor allergens like pollen, perennial allergies persist year-round due to indoor allergens, and perennial nonallergic rhinitis lasts for more than nine months each year without being triggered by specific allergens.
It is advisable not to take or limit alcohol as a precautionary measure.
Avamist 27.5mcg Nasal Spray is not recommended for use if you are pregnant as it may cause harm to your fetus. Consult your doctor before taking this medicine.
Avamist 27.5mcg Nasal Spray is not recommended for use if you are breastfeeding. It is not known whether this medicine is excreted in human breast milk. If you are breastfeeding, consult your doctor before taking this medicine.
Avamist 27.5mcg Nasal Spray usually does not affect your ability to drive or operate machinery.
Tell your doctor before receiving the Avamist 27.5mcg Nasal Spray if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.
Avamist 27.5mcg Nasal Spray should be used with caution if you have a liver problem due to the increased risk of severe side effects. Your doctor may advise a blood test to monitor your liver functions.
Fluticasone Furoate is a corticosteroid, which works by decreasing the inflammation caused by allergies. It reduces inflammation by blocking the release of certain natural substances that cause allergic symptoms such as swelling, redness, and pain.
Common side effects of Avamist include nosebleeds, headache, and nasal inflammation. This medication may lower the body's ability to fight infections, so caution should be exercised around individuals with contagious diseases like chickenpox, measles, or tuberculosis.
Fluticasone Furoate is used in the treatment of sneezing and runny nose due to allergies.
Fluticasone Furoate is a synthetic trifluorinated corticosteroid with potent anti inflammatory activity. Like other corticosteroids Fluticasone Furoate is found to have a wide range of actions on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (e.g.- histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation.
Avamist is administered as a nasal spray, and the dosage and duration should be as per your doctor's recommendation. The correct method of application involves inserting the bottle tip into one nostril, closing the other nostril, and directing the spray towards the sides of the nostril while breathing gently. This process should be repeated for the other nostril.
Avamist may lead to increased plasma concentrations of fluticasone when used with CYP4503A4 inhibitors like ritonavir. Therefore, it's essential to discuss all potential interactions with your doctor before starting any medication regimen.
Fluticasone Furoate nasal spray is contraindicated in patients with a hypersensitivity to any of its ingredients.
During pregnancy, Fluticasone Furoate nasal spray falls under Pregnancy Category C, indicating that there are no well-controlled studies in pregnant women to establish its safety. Therefore, its use during pregnancy should only be considered if the potential benefits to the mother outweigh the potential risks to the fetus. Pregnant women should consult with their healthcare provider before using Fluticasone Furoate nasal spray.
Regarding lactation, it is uncertain whether Fluticasone Furoate is excreted in human breast milk. However, other corticosteroids have been detected in breast milk. Therefore, caution should be exercised when administering Fluticasone Furoate to nursing women. Nursing mothers should discuss the risks and benefits of using Fluticasone Furoate nasal spray with their healthcare provider before starting the medication.
Precautions should be taken when using Avamist, especially in patients with recent nasal ulcers, surgery, or trauma. It is contraindicated in individuals with hypersensitivity to any of its ingredients. While systemic effects are minimal with recommended doses, larger doses should be avoided to minimize potential risks. Caution is advised during lactation, as data on distribution in breast milk are unknown.
Store at a temperature not exceeding 30°C. Do not refrigerate. Protect from light and moisture. Keep out of the reach of children.
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