Raditrol 0.25mcg Capsule 10pcs

Uses of Raditrol 0.25mcg Capsule

Raditrol is indicated in:

• Post-menopausal osteoporosis
• Renal osteodystrophy
• Postsurgical hypoparathyroidism
• Idiopathic hypoparathyroidism
• Pseudohypoparathyroidism
• Secondary hyperparathyroidism in patients with moderate to severe chronic renal failure (pre-dialysis)
• Vitamin D-dependent rickets

How does Raditrol 0.25mcg Capsule work?

Raditrol 0.25 raises Vitamin D levels in the blood, increasing calcium absorption from the intestine.

Side Effects of Raditrol 0.25mcg Capsule

Common side effects include injection site reactions like pain, swelling, and redness.

Quick Suggestions:

• Do not take other forms of Vitamin D without consulting your doctor.
• Take calcium supplements with Vitamin D3 as prescribed.
• Stay hydrated; drink plenty of fluids.
• Avoid antacids without a doctor's advice.
• Report metallic taste, muscle or joint pain, headache, or drowsiness to your doctor.

Indication of Raditrol 0.25mcg Capsule

• Renal Osteodystrophy

Renal Osteodystrophy is a skeletal abnormality characterized by low levels of calcium and phosphorus in the blood due to kidney failure. This condition mainly occurs due to chronic kidney disease (CKD) where the kidney does not function properly. Calcitriol is used in treating Renal osteodystrophy.

• Hypocalcemia

Hypocalcemia is a condition with low levels of calcium in blood or plasma. This mainly occurs due to kidney problems, Vitamin D deficiency, etc. Calcitriol is used in the treatment of hypocalcemia, thereby preventing the risk of bone disorders in the future.

• Hypoparathyroidism

Hypoparathyroidism is a condition of low levels of parathyroid hormone (an important hormone that maintains a balance of calcium and phosphorus). This condition may lead to decreased calcium levels and increased phosphorus levels in the blood. Calcitriol is used in the treatment of Hypoparathyroidism.

• Secondary Hyperparathyroidism

Secondary hyperparathyroidism is a condition with excessive secretion of parathyroid hormone (PTH) in response to low blood levels of calcium in the body. This condition mainly occurs due to severe kidney failure resulting in vitamin D deficiency. Calcitriol is used in the treatment of secondary hyperparathyroidism, thereby helping to maintain the normal secretion of PTH.

• Postmenopausal osteoporosis

Postmenopausal osteoporosis (Type I osteoporosis) is a bone condition that occurs after menopause. This condition occurs due to decreased estrogen levels leading to bone disorders. Calcitriol is used in the treatment of Postmenopausal osteoporosis.

Pharmacology

Raditrol contains Calcitriol, an active metabolite of vitamin D3, which promotes intestinal absorption of calcium and regulates bone mineralization. It plays a key role in calcium homeostasis, including stimulation effects on osteoblastic activity in the skeleton.

Dosage & Administration of Raditrol 0.25mcg Capsule

• Dosage is determined based on serum calcium levels and specific conditions.
• Capsules: Postmenopausal osteoporosis - 0.25 mcg twice daily; Renal osteodystrophy - 0.25 mcg/day initially; Hypoparathyroidism & Rickets - 0.25 mcg/day initially.
• Injection: Initial dose of 1-2 mcg three times weekly, adjusted based on severity.

Excess administration can lead to hypercalcemia, hypercalciuria, and hyperphosphatemia. Treatment involves discontinuation, a low-calcium diet, and withdrawal of supplements.

Interaction

• May develop hypermagnesemia in chronic renal dialysis patients.
• Hypercalcemia in patients on digitalis may cause cardiac arrhythmias.
• Reduced intestinal absorption with cholestyramine and colestipol.
• Reduced T1/2 with phenytoin and barbiturates.
• May develop hypercalcemia with thiazide diuretics.

Contraindications

Avoid hypercalcemia, evidence of vitamin D toxicity, and during pregnancy/lactation.

Pregnancy & Lactation

Calcitriol may be used during pregnancy if benefits outweigh risks. Breastfeeding mothers should monitor serum calcium levels in themselves and their infants.

Precautions & Warnings

• Monitor patients with idiopathic hypercalcemia closely.
• Individualize pediatric doses and monitor closely.
• Monitor renal function, especially in the elderly.
• Avoid dehydration in patients with normal renal function by taking Calcitriol.
• Not recommended during lactation due to entry into breast milk.

Storage Conditions:

Store in a dry place away from light and heat, out of the reach of children.

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