Cholecalciferol (Vitamin D3) converts to Calcitriol—the active form—via liver and kidney metabolism. Calcitriol binds to vitamin D receptors to regulate calcium absorption and metabolism. Being fat-soluble, it has a long half-life (~50 days) and is stored in fat and muscle tissues. Excretion occurs through feces and urine.
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Proper Packaging
Capsule (Adults):
Capsule (12–18 yrs):
Film-coated tablet: 1,000 IU daily (1–2 tablets)
Oroflash/Chewable: 1,000–2,000 IU/day
Safety not established in children under 12 years
Rare—may include nausea, headache, constipation, weight changes, polyuria, and elevated calcium/phosphate levels.
Decreased absorption/metabolism with antacids (Mg), digoxin, thiazide diuretics, cholestyramine, phenytoin, phenobarbital, corticosteroids, and mineral oil.
Safe up to 4,000 IU/day during pregnancy; follow physician’s guidance
Excreted in breast milk—monitor infant intake if supplementing both mother and child
Store below 30°C, away from light and moisture. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.