Toltrex 2 | 1 Strip

✔️ Side Effects | Toltrex 2

• Dry mouth (23.4% of patients)
• Headache
• Constipation
• Abdominal pain

✔️ Dosage & Administration | Toltrex 2

Extended-Release Capsule:

Recommended dose: 4 mg once daily.

Adjustments: May be reduced to 2 mg once daily based on tolerance and clinical response.

For patients with hepatic or renal impairment or those taking potent CYP3A4 inhibitors (e.g., ketoconazole), the dose should be 2 mg once daily.

Film-Coated Tablet:

Standard dose: 2 mg twice daily.

For patients with severe renal impairment (GFR <30 ml/min) or impaired liver function, use 1 mg twice daily.

If side effects occur, the dose may be lowered to 1 mg twice daily.

The therapeutic response should be reassessed after 2–3 months.

Pediatric Use: Safety and efficacy in children have not been established.
Geriatric Use: No significant difference in safety between older and younger adults.

✔️ Interaction

Co-administration with CYP3A4 inhibitors such as ketoconazole, itraconazole, miconazole, erythromycin, clarithromycin, cyclosporine, or vinblastine may significantly increase Toltrex levels.
In such cases, the dose should be reduced to 2 mg daily.

✔️ Toltrex is contraindicated in patients with:

• Urinary retention
• Gastric retention
• Uncontrolled narrow-angle glaucoma
• Known hypersensitivity to Tolterodine or its components

✔️ Pregnancy & Lactation

No adequate studies exist in pregnant women; use only if the potential benefit outweighs the risk.

It is unknown whether Tolterodine is excreted in breast milk; therefore, avoid use during lactation or discontinue breastfeeding during treatment.

✔️ Precautions & Warnings

• Use with caution in patients with bladder outflow obstruction (risk of urinary retention) or gastrointestinal obstructive disorders (risk of gastric retention).
• Caution is also advised in patients with narrow-angle glaucoma.
• In patients with hepatic or renal impairment, the maximum recommended dose is 2 mg daily.
• Toltrex may cause blurred vision, dizziness, or drowsiness—patients should be cautioned when driving or operating machinery.
• Prolonged use of high doses (8 mg/day) may cause QT interval prolongation, especially in poor CYP2D6 metabolizers or when combined with Class IA or Class III antiarrhythmics (e.g., quinidine, amiodarone, sotalol).

✔️ Storage:

Store in a cool, dry place, protected from light and moisture.
Keep out of reach of children.