Alkanon 1000mg Tablet

✔️ Uses of Alkanon 1000mg Tablet

Alkanon 1000mg Tablet is prescribed for alleviating symptoms linked to Osteoarthritis, including tender and painful joints. It is also utilized in the treatment of Rheumatoid Arthritis, addressing issues such as joint swelling, pain, and stiffness.

✔️ How does Alkanon 1000mg Tablet work?

Nabumetone is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).

✔️ Side Effects of Alkanon 1000mg Tablet

• Gastrointestinal: Diarrhea, dyspepsia, abdominal pain, constipation, etc.
• Central Nervous System: Dizziness, headache, fatigue, insomnia, etc.
• Dermatologic: Pruritus, rash.
• Special Senses: Tinnitus.
• Miscellaneous: Edema.

✔️ Quick Suggestions:

• You have been prescribed Nabumetone to relieve pain and inflammation.
• Take it with food or milk to prevent an upset stomach.
• Take it as per the dose and duration prescribed by your doctor. Long-term use may lead to serious complications such as stomach bleeding and kidney problems.
• It may cause dizziness, drowsiness, or visual disturbances. Use caution while driving or doing anything that requires concentration.
• Avoid consuming alcohol while taking Nabumetone as it can cause excessive drowsiness and increase your risk of stomach problems.
• Inform your doctor if you have a history of heart disease or stroke.
• Your doctor may regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

✔️ Indications

• Relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.
• Careful consideration of benefits and risks is advised.
• Use the lowest effective dose for the shortest duration.

✔️ Pharmacology

• Exhibits anti-inflammatory, analgesic, and antipyretic properties.
• Prodrug: Metabolized to active component (6MNA) inhibiting prostaglandin synthesis.

✔️ Dosage & Administration of Alkanon 1000mg Tablet

• 500 mg & 750 mg Tablet: Oral.
• 1000 mg Tablet: Mix with water and drink.
• Starting dose: 1000 mg once daily with/without food.
• Adjust dose based on individual response.
• Avoid doses >2000 mg/day; lowest effective dose for chronic treatment.

✔️ Renal Insufficiency:

• Caution with moderate or severe renal insufficiency.
• Maximum starting doses in such patients: 750 mg or 500 mg once daily.
• Adjust doses based on careful renal function monitoring.

✔️ Pediatric Use:

• Safety and effectiveness not established.

✔️ Interactions:

• NSAIDs may diminish the antihypertensive effect of ACE inhibitors.

✔️ Contraindications:

• Known hypersensitivity to nabumetone or its excipients.
• Avoid in patients with asthma, urticaria, or allergic reactions to aspirin/NSAIDs.
• Contraindicated for peri-operative pain in CABG surgery.

✔️ Pregnancy & Lactation

• Category C: Use during pregnancy only if needed.
• Not recommended during the third trimester.
• Not recommended for nursing mothers due to potential adverse effects.

✔️ Overdose Effect

• Symptoms: Lethargy, drowsiness, nausea, vomiting, epigastric pain.
• Manage with symptomatic and supportive care.
• No specific antidotes reported.

✔️ Precautions & Warnings:

• NSAIDs associated with renal papillary necrosis.
• Caution in patients with reduced renal blood flow, heart failure, liver dysfunction, and elderly.
• Discontinuation in case of renal decompensation.

✔️ Storage Conditions:

• Store in a cool, dry place, away from light and moisture.
• Keep out of reach of children.