Alkanon 500mg Tablet

✔️ Uses of Alkanon 500mg Tablet

• Pain Relief

✔️ How does Alkanon 500mg Tablet work?

Nabumetone works by blocking the effects of COX enzymes. This prevents prostaglandin synthesis (prostaglandins elevate body temperature and make nerve endings more sensitive to pain transmission).

✔️ Side Effects of Alkanon 500mg Tablet

• Common (>10%): Diarrhea (14%), Dyspepsia (13%), Abdominal pain (12%)
• 1-10%: Constipation (3-9%), Dizziness (3-9%), Edema (3-9%), Flatulence (3-9%), Headache (3-9%), Nausea (3-9%), Positive stool guaiac (3-9%), Pruritus (3-9%), Rash (3-9%), Tinnitus (3-9%), Dry mouth (1-3%), Fatigue (1-3%), Gastritis (1-3%), Increased sweating (1-3%), Insomnia (1-3%), Nervousness (1-3%), Somnolence (1-3%), Stomatitis (1-3%), Vomiting (1-3%)

✔️ Quick Suggestions:

• You have been prescribed Alkanon 500mg Tablet to relieve pain and inflammation.
• Take it with food or milk to prevent an upset stomach.
• Take it as per the dose and duration prescribed by your doctor. Long-term use may lead to serious complications such as stomach bleeding and kidney problems.
• It may cause dizziness, drowsiness, or visual disturbances. Use caution while driving or doing anything that requires concentration.
• Avoid consuming alcohol while taking Alkanon 500mg Tablet as it can cause excessive drowsiness and increase your risk of stomach problems.
• Inform your doctor if you have a history of heart disease or stroke.
• Your doctor may regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

✔️ Osteoarthritis:

Osteoarthritis is a joint disease characterized by the breakdown of the protective cartilage covering the ends of the joints. In this condition, the absence of protective cartilage causes the joints to come together, resulting in friction between them. This leads to symptoms such as pain, stiffness, inflammation, and tenderness. Individuals with osteoarthritis may experience discomfort and limited mobility due to the rubbing of joints against each other.

✔️ Rheumatoid Arthritis:

Rheumatoid arthritis is an autoimmune disease where the body's immune system mistakenly attacks its tissues, specifically the joints. This immune system activity causes joint pain and damage over time. Symptoms of rheumatoid arthritis encompass pain, swelling, stiffness, deformities, and loss of joint function. Unlike osteoarthritis, rheumatoid arthritis involves an inflammatory process driven by the immune system, leading to more widespread and systemic effects on the body. Early diagnosis and appropriate management are crucial in mitigating the impact of rheumatoid arthritis on joint health.

✔️ Pharmacology:

Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2. May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity.

✔️ Dosage & Administration:

Adult Dose:

• Oral Adult Osteoarthritis: 1g PO once daily initially; maintenance: 1-2 g/day PO in a single daily dose or divided q12hr; not to exceed 2 g/day
• Rheumatoid Arthritis: 1 g PO once daily initially; maintenance: 1-2 g/day PO in a single daily dose or divided q12hr; not to exceed 2 g/day
• Elderly: 500 mg daily may be adequate in certain patients. Max: 1 g daily.

Child Dose: Not recommended

Renal Dose:

• Renal impairment: CrCl (ml/min) Dosage Recommendation
  • 30-49: Max initial dose: 750 mg once daily. Increase if needed to a max dose of 1.5 g daily.
  • <30: Max initial dose: 500 mg once daily. Increase if needed to a max dose of 1 g daily.

✔️ Interaction

• Antihypertensive effects of hypotensive agents may be reduced.
• May increase ciclosporin levels.
• Increased risk of seizures with fluoroquinolones.
• May reduce the efficacy of diuretics.
• May diminish the cardioprotective effect of acetylated salicylates.
• Alcohol may enhance gastric mucosal irritation.
• Potentially Fatal: Increased risk of bleeding with anticoagulants (e.g., warfarin, heparin, LMWHs) and antiplatelet agents (e.g., ticlopidine, clopidogrel, aspirin, abciximab, dipyridamole, eptifibatide, tirofiban).
• Increased risk of GI ulceration with corticosteroids.
• Severe bone marrow suppression, aplastic anemia, and GI toxicity may occur with methotrexate.

✔️ Contraindications

• Absolute: Aspirin allergy, severe renal impairment; perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
• Relative: Duodenal/gastric/peptic ulcer, stomatitis, systemic lupus erythematosus, ulcerative colitis, late pregnancy (may cause premature closure of ductus arteriosus)

✔️ Pregnancy & Lactation

Pregnancy category: C; D if used for prolonged periods or near term (premature closure of ductus arteriosus)

✔️ Precautions & Warnings

• Pre-existing CV risk factors or disease; fluid retention, CHF, hypertension.
• History of GI disease (bleeding or ulcers).
• Elderly or debilitated patients.
• Other forms of asthma.
• Hepatic impairment; closely monitor patients with any abnormal LFT.
• Renal impairment; rehydrate the patient before therapy and closely monitor renal function.
• Withhold for at least 4-6 half-lives before surgical or dental procedures.

✔️ Storage Conditions

Store in a cool and dry place away from sunlight