Alkanon 750mg Tablet | 6pcs Strip | 24pcs Box | Price | ePharma
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Alkanon 750mg Tablet-6pcs

Generic: Nabumetone

Type: Tablet

Pack Size: 6 Pcs

Nabumetone is used to relieve pain and inflammation in conditions such as Osteoarthritis and Rheumatoid Arthritis.


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Discount Price: ৳ 130.56
MRP: ৳ 136 4% Off

⪼ Save  ৳: 5.44  in this Product


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✅ Description:

  • Alkanon 750mg Tablet is a pain-relieving medicine.
  • Effective for alleviating pain and inflammation in conditions like rheumatoid arthritis and osteoarthritis.
  • Take as advised by your doctor.
  • Should be taken with food or milk to prevent stomach upset.
  • Regular monitoring of kidney function, liver function, and blood components.
  • Especially crucial during long-term treatment.
  • Long-term use may lead to serious complications.
  • Complications include stomach bleeding and kidney problems.

Safety Advices


Alcohol
UNSAFE
  • It is unsafe to consume alcohol with Alkanon 750mg Tablet.
  • Rationale: Alcohol use can exacerbate the side effects of the medication and increase the risk of adverse reactions.

Pregnancy
UNSAFE
  • Alkanon 750mg Tablet may be unsafe to use during pregnancy.
  • Limited human studies, coupled with animal studies indicate potential harm to the developing baby.
  • Your doctor will assess the benefits and risks before prescribing. Consult your doctor for guidance.

Breastfeeding
UNSAFE
  • Alkanon 750mg Tablet is probably unsafe during breastfeeding.
  • Limited human data suggests potential harm to the baby through breast milk.
  • Consult your doctor for advice and consider alternative options.

Driving
CAUTION
  • Alkanon 750mg Tablet may cause side effects affecting your ability to drive.
  • Symptoms like dizziness, fatigue, vision problems, or headaches may impair driving skills.

Kidney
CAUTION
  • Use with caution in patients with kidney disease.
  • Dose adjustment may be necessary. Consult your doctor.
  • Regular kidney function tests and blood tests are advised during therapy.

Liver
CAUTION
  • Use with caution in patients with liver disease.
  • Dose adjustment may be needed. Consult your doctor.
  • Not recommended in severe liver disease cases.

Similar Products

✔️ Rheumatoid Arthritis

Rheumatoid Arthritis is an autoimmune disease, wherein the body's immune system mistakenly attacks its tissues, particularly the joints. This immune response triggers inflammation, resulting in joint pain and damage. The condition can lead to various symptoms, including pain, swelling, stiffness, deformities, and a gradual loss of joint function.

Symptoms of Rheumatoid Arthritis:

  • Pain: Individuals with rheumatoid arthritis often experience persistent joint pain, which may vary in intensity.
  • Swelling: Inflammation caused by the immune system's attack on the joints results in swelling, leading to increased joint size.
  • Stiffness: Stiffness is a common symptom, particularly in the morning or after periods of inactivity. Joints may feel rigid and challenging to move.
  • Deformities: Over time, rheumatoid arthritis can cause joint deformities, altering their normal appearance and function.
  • Loss of Joint Function: Progressive damage to the joints can result in a gradual loss of their normal range of motion and overall function.

Managing rheumatoid arthritis typically involves a multidisciplinary approach, including medications, physical therapy, lifestyle modifications, and sometimes surgical interventions. Early diagnosis and intervention play a crucial role in mitigating symptoms and preventing long-term joint damage. Individuals experiencing symptoms suggestive of rheumatoid arthritis should seek prompt medical attention for an accurate diagnosis and appropriate management.

✔️ Osteoarthritis

Osteoarthritis is a joint disease characterized by the breakdown of the protective cartilage covering the ends of the joints. This protective cartilage normally allows smooth movement of the joint surfaces. However, when it deteriorates, the joints lose their cushioning, causing the two ends of the joints to come together. As a result, the joints rub against each other during movement, leading to pain and stiffness.

Symptoms of Osteoarthritis:

  • Pain: Individuals with osteoarthritis experience pain, often described as aching or soreness, particularly during or after movement.
  • Stiffness: Joint stiffness, especially after periods of inactivity or upon waking up in the morning, is a common symptom.
  • Inflammation: Inflammation in the affected joints can cause swelling, warmth, and redness.
  • Tenderness: The affected joints may be tender to the touch, and pressure or stress on these joints can exacerbate pain.

Osteoarthritis commonly affects weight-bearing joints such as the knees, hips, and spine, as well as joints in the hands. Risk factors for osteoarthritis include aging, joint injuries, obesity, and genetic factors.

Management of osteoarthritis involves a combination of lifestyle modifications, exercise, medications, and sometimes surgical interventions. While osteoarthritis is a chronic condition, effective management strategies can help alleviate symptoms and improve the quality of life for individuals affected by this joint disease. If you suspect osteoarthritis or experience joint-related symptoms, consulting a healthcare professional for an accurate diagnosis and appropriate treatment plan is advisable.

✔️ Uses:
  • Pain Relief
✔️ How does

It works by blocking the formation of chemical substances which cause pain and swelling.

✔️ Side Effects of
  • Insomnia (difficulty sleeping)
  • Headache
  • Diarrhea
  • Nausea
  • Fatigue
  • Dry mouth
  • Loss of appetite
  • Indigestion
✔️ Quick Suggestions:
  • Take Nabumetone exactly as instructed by the doctor. Do not take in larger or smaller amounts than advised/prescribed.
  • Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed.
  • Do not stop the use of this medicine without consulting your doctor.
✔️ Indications:

Nabumetone Tablet is a pain-relieving medicine

✔️ Pharmacology

It is a non-selective prostaglandin G/H synthase inhibitor, commonly known as cyclooxygenase or COX inhibitor. It acts on both prostaglandin G/H synthase 1 (COX-1) and prostaglandin G/H synthase 2 (COX-2). Prostaglandin G/H synthase plays a key role in the conversion of arachidonic acid to prostaglandin G2 and further to prostaglandin H2. Prostaglandin H2 is a precursor to various prostaglandins that are involved in processes such as fever, pain, swelling, inflammation, and platelet aggregation. Alkanon 750 mg is a prodrug, meaning it is an inactive compound that undergoes hepatic biotransformation to the active component, 6-methoxy-2-naphthylacetic acid (6MNA). The active component, 6MNA, acts as a potent inhibitor of prostaglandin synthesis. This inhibition is likely achieved through binding to both COX-2 and COX-1 receptors. The overall effects of Alkanon 750 mg include analgesic (pain relief), antipyretic (fever reduction), and anti-inflammatory effects. These actions contribute to its therapeutic effects in conditions associated with pain, inflammation, and fever.

✔️ Dosage & Administration:

Adult Dose:

Osteoarthritis: Initially, 1g orally once daily; maintenance dose is 1-2g per day orally in a single daily dose or divided every 12 hours. The maximum dose should not exceed 2g per day.

Rheumatoid Arthritis: Initially, 1g orally once daily; maintenance dose is 1-2g per day orally in a single daily dose or divided every 12 hours. The maximum dose should not exceed 2g per day.

Elderly: A daily dose of 500mg may be adequate in certain elderly patients. The maximum daily dose should not exceed 1g.

Child Dose:

  • Not recommended: Alkanon 500 is not recommended for use in children.

Renal Dose:

  • Renal Impairment (CrCl - Creatinine Clearance):
    • CrCl 30-49 ml/min: The maximum initial dose is 750mg once daily. Increase if needed to a maximum dose of 1.5g daily.
    • CrCl <30 ml/min: The maximum initial dose is 500mg once daily. Increase if needed to a maximum dose of 1g daily.

These dosage recommendations take into consideration the patient's age, the specific condition being treated (osteoarthritis or rheumatoid arthritis), and renal function. It's essential to follow the prescribed dosage and consult with a healthcare professional for personalized advice, especially in the case of renal impairment. Regular monitoring of renal function is advised when using Alkanon 500 in patients with renal impairment.

✔️ Interaction

Inform your doctor if you are taking the following medications along with the prescribed drug:

Antidepressants:

  • Duloxetine
  • Escitalopram
  • Fluoxetine
  • Sertraline

Diuretics:

  • Hydrochlorothiazide

Anti-Hypertensive:

  • Lisinopril

Corticosteroid:

  • Prednisone

Anti-Diabetic:

  • Metformin

Drug-Food Interactions:

No interactions with food have been found or established.

Drug-Disease Interactions:

Inform your doctor if you have any of the following medical conditions:

  1. Asthma
  2. Fluid retention
  3. Gastrointestinal toxicity
  4. Kidney problems
  5. Thrombosis
  6. Liver disease
  7. Anemia
  8. Heart problems
  9. High blood pressure
  10. High potassium levels
  11. Platelet aggregation inhibition
✔️ Contraindications
  • Contraindicated in patients with known hypersensitivity to Alkanon 750 mg or its excipients.
  • Avoid use in individuals who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
  • Alkanon 750 mg should not be given to patients with a history of severe, rarely fatal, anaphylactic reactions to NSAIDs.
  • Such reactions have been reported in individuals with a specific sensitivity to nonsteroidal anti-inflammatory drugs.
  • Contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
  • Avoid use in this specific surgical context due to potential risks.
✔️ Pregnancy & Lactation

Pregnancy Category: C

Reproductive Studies (Animal): Reproductive studies conducted in rats and rabbits did not show evidence of developmental abnormalities. However, it's important to note that animal reproduction studies may not always predict human response.

Human Studies: There are no adequate, well-controlled studies in pregnant women. Alkanon 750 mg should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers: The excretion of the drug in human milk is not known. However, 6MNA (active component) is excreted in the milk of lactating rats. Due to the potential for serious adverse reactions in nursing infants from Alkanon 750 mg, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Labor and Delivery (Animal Studies): In rat studies with NSAIDs, including Alkanon 750 mg, there was an increased incidence of dystocia (difficult labor), delayed parturition (delivery), and decreased pup survival. The effects of Alkanon 750 mg on labor and delivery in pregnant women are unknown.

✔️ Precautions & Warnings
  • Inform your doctor if you have or have asthma, stomach problems (Crohn’s disease or ulcerative colitis), liver, kidney, or heart problems.
  • Disclose a history of high blood pressure, stroke, edema, autoimmune diseases, diabetes, high cholesterol, and infections.
  • Notify if you are in the first six months of pregnancy, a smoker, or if you are above 65 years of age.
  • Nabumetone is not recommended for children.
  • Stop taking it immediately and consult a doctor if you experience difficulty breathing, face or throat swelling, severe rash, chest pain, sudden numbness, or confusion.
  • Do not take Nabumetone if you've recently had a heart attack unless prescribed by your doctor.
  • Seek emergency medical help for symptoms such as chest pain, weakness on one side of the body, shortness of breath, or slurred speech.
  • Nabumetone may cause gastrointestinal events, including bleeding, ulceration, and perforation of the stomach or intestines.
  • If you experience symptoms like stomach pain, bloody vomit, heartburn, blood in stool, or black and tarry stools, stop taking and consult your doctor immediately.
✔️ Storage Conditions

Store in a cool and dry place, away from light & moisture. Keep all medicines out of reach of children.

Frequently Asked Questions (FAQ)
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Check our pricing section for Alkanon 750mg Tablet-6pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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