Caprogen DS Injection | 500mg/2ml | ePharma
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Caprogen DS Injection

Generic: Hydroxyprogesterone Caproate

Type: Injection

Pack Size: 1 Pc

  • Reduces the preterm birth risk in women with a singleton pregnancy having a history of preterm delivery
  • Prevents premature labor and miscarriage in pregnant women

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Discount Price: ৳ 611
MRP: ৳ 650 6% Off

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✅ Description:

Caprogen DS Injection is a synthetic progesterone female hormone (progestin) used to prevent premature labor. It is indicated for pregnant women at risk of preterm labor, typically caused by factors such as premature rupture of membranes, high blood pressure (pre-eclampsia), and poor diet.

The active ingredient in Caprogen DS Injection is hydroxyprogesterone, which is a progestin that helps modulate the immune response in pregnant women, preventing the rejection of the embryo and facilitating its attachment to the uterus. By doing so, it helps prevent miscarriage and reduce the risk of premature birth, particularly in women who have had a previous preterm delivery.

Caprogen DS Injection should only be administered by a healthcare professional and should not be self-administered. Common side effects may include nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue, or throat, and diarrhea. However, not everyone experiences these side effects, and most of them resolve on their own over time. If you experience any discomfort while taking Caprogen DS Injection, it is advisable to consult your doctor.

Before starting treatment with Caprogen DS Injection, inform your doctor about any allergies to medications, any unusual vaginal bleeding related to your pregnancy, and your medical history, especially if you have liver disease, severe hypertension, a history of breast cancer, uterus or vagina disorders, pre-eclampsia, thromboembolic disorders, diabetes, depression, or epilepsy. Caprogen DS Injection may cause dizziness, so caution should be exercised when driving or operating machinery. Alcohol consumption should be avoided to prevent potential unpleasant side effects. It is important to inform your doctor about all the medications you are taking and your overall health condition to ensure the appropriate and safe use of Caprogen DS Injection.

Safety Advices


Alcohol
UNSAFE

There is no data regarding interactions between Caprogen DS Injection and alcohol. However, this does not rule out the possibility of interaction and it is better to avoid alcohol consumption.


Pregnancy
CONSULT YOUR DOCTOR

There is limited information about the use of Caprogen DS Injection during pregnancy. Consult your doctor before using this injection.


Breastfeeding
CONSULT YOUR DOCTOR

Components of Caprogen DS Injection pass into the breastmilk in a small amount. Consult your doctor before using this medicine during breastfeeding.


Driving
UNSAFE

Caprogen DS Injection may make you dizzy. Avoid driving if you do not feel well or are unable to be alert.


Kidney
CONSULT YOUR DOCTOR

Caprogen DS Injection should be used with caution in patients with kidney problems. Consult your doctor before receiving Caprogen DS Injection.


Liver
CONSULT YOUR DOCTOR

Caprogen DS Injection is not recommended for use in patients with liver problems such as liver tumors or any other active liver disease. It should be used with caution in patients with liver impairment. Consult your doctor before receiving Caprogen DS Injection.

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✔️ Uses of Caprogen DS Injection
  • Premature labor
  • Amenorrhoea
✔️ How does Caprogen DS Injection work?

Hydroxyprogesterone Caproate is a synthetic preparation of progesterone hormone that acts by controlling the female reproductive system and plays a critical part in effectively implanting the embryo in the womb. It also causes an anti-inflammatory response, which can lead to pre-term labor.

✔️ Side Effects of Caprogen DS Injection
  • Injection site pain
  • Injection site swelling
  • Red spots or bumps
  • Diarrhea
✔️ Quick Suggestions:
  • Caprogen DS Injection is specifically used in pregnant women to reduce the risk of preterm birth (giving birth too early). It is given to women who have previously experienced preterm delivery. It should not be used in women who are pregnant with multiple babies (such as twins or triplets).
  • The injection is administered by a doctor or under their immediate supervision. It is typically given once a week starting between 16 and 20 weeks of pregnancy and continuing until week 37 or until delivery occurs.
  • In addition to receiving the injection, it is recommended to include heart-healthy foods and drinks that contain omega-3 fatty acids in your daily diet. Opt for low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil. Focus on consuming whole foods and grains rather than processed foods high in sugar and fat.
  • Stress should be avoided as it can increase the risk of preterm delivery. Engaging in activities you enjoy and spending time with loved ones can help manage stress. Practicing mindfulness techniques may also be beneficial.
  • Regular physical activity and yoga are encouraged as they help maintain fitness, improve blood circulation, and regulate oxygen supply, thus increasing the chances of carrying the baby to full term.
  • Quitting smoking is crucial to reducing the risk of premature delivery. It is important to maintain a healthy weight and limit alcohol intake, as it can affect the stomach, intestine, and absorption of essential nutrients.
  • A balanced diet that includes vegetables, fruits, and whole grains is recommended to decrease the risk of preterm delivery.
  • You should not receive Caprogen DS Injection if you are allergic to hydroxyprogesterone or castor oil. It is also not recommended for use in women under 16 years of age. The injection will not stop premature labor if it has already begun.
  • Monitoring blood sugar levels regularly is important as Caprogen DS Injection may affect them. If you notice yellowing of the eyes or skin, dark urine, or stomach pain, it could be a sign of a serious liver problem, and you should inform your doctor immediately.
  • In case of experiencing chest pain, groin or leg pain, difficulty breathing, sudden severe headache, slurred speech, sudden unexplained shortness of breath, a sudden loss of coordination, or changes in vision while using this medicine, it is important to inform your doctor right away. These symptoms may require immediate medical attention.
✔️ Indication of Caprogen DS Injection

Caprogen DS Injection contains hydroxyprogesterone as its active ingredient. It is used in reducing the risk of premature birth in a female who previously delivered a premature baby.

✔️ Pharmacology

500mg/2ml Caprogen DS Injection is a man-made, injectable version of the female hormone progesterone that helps reduce the risk of preterm delivery, especially in women who have experienced this issue in a previous pregnancy. Progesterone is a hormone that thickens the uterine lining and prepares it for the baby's growth and development. As a result, it promotes uterine growth while also preventing contractions that might lead to miscarriage.

✔️ Dosage & Administration of Caprogen DS Injection

Administration:

  • Caprogen DS Injection is administered via intramuscular (IM) injection.
  • Inject the medication over 1 minute in the upper outer quadrant of the gluteus maximus.
  • The solution is viscous and oily.
  • The 1 mL vial does not contain preservatives and is for single-dose use.
  • The 5 mL multidose vial must be used within 5 weeks after opening.

Adult Dose:

Preterm Labor Prevention:

  • Indicated for the prevention of preterm labor in a singleton pregnancy for patients aged 16 years or older who have a history of spontaneous preterm birth.
  • The recommended dose is 250 mg IM once a week.
  • Initiate treatment between the 16th and 20th week of gestation and continue until the 37th week of gestation or birth (whichever is first).

Recurrent Miscarriage:

  • The recommended dose is 250-500 mg weekly during the first half of pregnancy.

Amenorrhea and Abnormal Uterine Bleeding:

  • A single dose of 375 mg can be administered, and it may be repeated at 4-week intervals if needed.
  • After 4 days of desquamation or if there is no bleeding within 21 days after administration of the drug, cyclic therapy can be initiated.
  • For cyclic treatment (28-day cycle): On day 1, administer 20 mg of estradiol valerate, and on day 15, administer 250 mg of hydroxyprogesterone caproate and 5 mg of estradiol valerate.
  • Cyclic therapy can be repeated at 4-week intervals as needed.

Palliative Treatment of Advanced, Inoperable Endometrial Carcinoma:

  • The usual dose is 1 g, which may be repeated once or more times weekly.
  • The usual range is 1-7 g per week.
  • Discontinue treatment if relapse occurs or if the objective response is not achieved after 12 weeks of treatment.

Hepatic Impairment:

  • Caprogen DS Injection has not been studied in patients with hepatic impairment. Since the product is extensively metabolized in the liver, there may be a potential for reduced elimination in patients with hepatic impairment.

Child Dose:

  • The safety and efficacy of Caprogen DS Injection have not been established in children.

Renal Dose:

  • Caprogen DS Injection has not been studied in patients with renal impairment. There is no specific dosing information available for patients with renal impairment.

Please note that the information provided is based on the details you provided, and it's important to consult with a healthcare professional or follow the specific instructions and recommendations of your doctor for accurate dosing and administration of Caprogen DS Injection.

✔️ Interaction
  • Caprogen DS Injection can interact with several medications. Some of the interactions include:
  • Painkillers (acetaminophen): There can be an interaction between Caprogen DS Injection and painkillers like acetaminophen. It is important to inform your doctor about all the medications you are taking, including painkillers, to ensure they are safe to use together.
  • Anti-epilepsy medicines (primidone, phenytoin, carbamazepine): Caprogen DS Injection may interact with anti-epilepsy medications. Your doctor will consider these interactions and may adjust the dosages accordingly.
  • Antidiabetic medications (metformin, glimepiride, glipizide, canagliflozin): There can be interactions between Caprogen DS Injection and anti-diabetic medications. Close monitoring of blood sugar levels may be necessary, and your doctor may need to adjust your diabetes medication regimen.
  • Medications used to treat HIV (efavirenz): Caprogen DS Injection may interact with efavirenz, a medication used to treat HIV. Your doctor will consider these interactions and may adjust the treatment plan accordingly.
  • Medications used to treat fungal infections (griseofulvin, ketoconazole, itraconazole, posaconazole): Caprogen DS Injection may interact with medications used to treat fungal infections. Your doctor will consider these interactions and may adjust the treatment plan accordingly.
  • It is important to note that Caprogen DS Injection may also interact with grapefruit and alcohol. Grapefruit can interfere with the metabolism of certain medications, including Caprogen DS Injection. It is recommended to avoid grapefruit or grapefruit juice while taking this medication. Alcohol consumption should also be avoided as it can potentiate the dizziness and drowsiness caused by Caprogen DS Injection.
  • Additionally, Caprogen DS Injection should be used with caution in certain medical conditions such as breast cancer, thromboembolism, depression, diabetes, fluid retention, and kidney or liver disease. Your doctor will consider these factors and evaluate the potential risks and benefits before prescribing Caprogen DS Injection.
  • It is crucial to inform your doctor about all your medical conditions and medications, including over-the-counter drugs and herbal supplements, to ensure the safe and effective use of Caprogen DS Injection.
✔️ Contraindications
  • Undiagnosed Vaginal Bleeding: Caprogen DS Injection should not be taken if you have unusual vaginal bleeding that is not related to your pregnancy.
  • Breast Cancer: Caprogen DS Injection should not be used if you have a history of breast cancer.
  • Pregnancy and Lactation: Caprogen DS Injection is indicated for use in pregnant women to help lower the risk of giving birth prematurely. It is not recommended for use during lactation.
  • Thrombophlebitis, Thromboembolic Disorders, Cerebral Apoplexy, or History of these Conditions: Caprogen DS Injection should not be taken if you have a history of thrombophlebitis, thromboembolic disorders (blood clot formation in blood vessels), cerebral apoplexy (stroke), or if you have a history of these conditions.
  • Markedly Impaired Liver Function: Caprogen DS Injection should not be used in individuals with markedly impaired liver function.
✔️ Pregnancy & Lactation

No adequate or well-controlled studies in women during the first trimester

✔️ Precautions & Warnings
  • You should not take Caprogen DS Injection without a doctor's advice. It is important to inform your doctor about any allergies you have to medications.
  • Caprogen DS Injection should not be used if you have unusual vaginal bleeding unrelated to your pregnancy, liver disease, severe hypertension (high blood pressure), or a history of breast, uterus, or vaginal cancer. Inform your doctor if you have had preeclampsia (high blood pressure during pregnancy), thromboembolic disorders (blood clots in the blood), diabetes, depression, or epilepsy before using Caprogen DS Injection.
  • Do not administer Caprogen DS Injection on your own. It can cause dizziness and drowsiness, so be cautious when driving or operating machinery.
  • Inform your doctor if you are breastfeeding, as they will evaluate the benefits and potential risks before prescribing the medication.
  • Caprogen DS Injection is not recommended for children under 16 years of age and is not intended for use during the first trimester of pregnancy. It is important to consult with your doctor and follow their guidance regarding the use of Caprogen DS Injection.
✔️ Storage Conditions
  • Store Caprogen DS Injection at room temperature. Keep it away from children and pets. Do not freeze.
Frequently Asked Questions (FAQ)

It is given by medical practitioners only or under the supervision of a medical professional.

The active component in Caprogen DS Injection is hydroxyprogesterone. Hydroxyprogesterone is a synthetic progestin, and its mechanism of action in preventing or reducing preterm birth is unknown. It compensates for the lack of hormones and encourages the development of an undeveloped uterus.

Caprogen DS Injection is a manmade form of a female hormone and is used to reduce the risk of premature birth in a female who has already delivered a premature baby in the past.

Progesterone is an endogenous steroid and progestogen sex hormone released by the female reproductive organ in the second half of the menstrual cycle to prepare the uterus for egg release. It is also required for the implantation of the fertilized egg in the uterus, pregnancy maintenance, and hormone replacement treatment in women who are progesterone deficient.

The time taken for Caprogen DS Injection to show its effect to show its action is clinically unknown.

The time duration for which Caprogen DS Injection remains effective in the body is 1-2 weeks.

Ideally, you should try not to miss any dose. However, if you miss a dose consult with your doctor as soon as you remember.

Caprogen DS Injection will be administered only by a doctor or nurse in the back of your upper arm subcutaneously (under the skin) or intramuscularly (in your muscle). Your doctor will determine the appropriate dose and duration for you based on your age, weight, and medical status.

Caprogen DS Injection is not indicated for pregnant women who have cholestatic jaundice or undetected abnormal vaginal bleeding unrelated to pregnancy. It should be taken with caution in pregnant women who are carrying a singleton pregnancy and have a history of premature birth. Before you get it, consult your doctor.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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