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Nitro 400mcg Spray
Nitroglycerin primarily relaxes vascular smooth muscle, producing vasodilation in both arteries and veins, with a more pronounced effect on veins. It reduces preload by pooling blood in the peripheral veins and lowers afterload by dilating arteries, thus decreasing cardiac workload and myocardial oxygen demand.
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✅ Description:
Nitro is an organic nitrate functioning as a vasodilator. Each metered spray delivers 400 mcg of nitroglycerin in droplet form under the tongue, with a total of 200 sprays per container.
Nitro Sublingual Spray is indicated for:
Immediate relief of angina pectoris attacks associated with coronary artery disease.
Prevention of angina episodes triggered by physical or emotional stress.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
Possible adverse effects include:
- Headache, dizziness, flushing, nausea, vomiting.
- Weakness, postural hypotension, reflex tachycardia.
✔️ Overdose Management
Symptoms: Severe hypotension, headache, flushing, nausea, syncope, methemoglobinemia, visual changes, seizures, or circulatory collapse.
Treatment:
Keep the patient in a recumbent position with elevated legs.
Administer oxygen and provide ventilatory support as needed.
For methemoglobinemia, administer methylene blue IV (1–2 mg/kg of 1% solution).
Gastric lavage may be helpful if ingestion was recent.
✔️ Dosage & Administration
- At the onset of angina: Administer 1 or 2 sprays under the tongue.
- Maximum dose: Do not exceed 3 sprays within 15 minutes.
- Prophylactic use: Administer 5–10 minutes before exertion or anticipated triggers.
If chest pain persists after administration, seek immediate medical help.
Pediatrics: Safety and efficacy not established.
Use cautiously in patients with renal/hepatic impairment, hypothyroidism, malnutrition, or hypothermia.
ঔষধটি রুটিন ব্যবহারের জন্য নয়, কেবলমাত্র বুকে ব্যথা শুরু হলে ব্যবহার করুন।
✔️ Usage Instructions
- Sit down as soon as symptoms appear.
- Remove the cap; do not shake the canister.
- Hold upright with your index finger on the spray button.
- Aim under the tongue and press the button slowly.
- Close the mouth and avoid swallowing or drinking water for 5–10 minutes.
- If needed, repeat the above steps after a short interval.
- Keep an extra supply accessible (e.g., on a bedside table) at all times.
✔️ Drug Interactions
- Alcohol may enhance hypotensive effects.
- May interact with dihydroergotamine, increasing bioavailability.
- Additive hypotension may occur with calcium channel blockers, phenothiazines, and tricyclic antidepressants.
✔️ Contraindicated in:
- Hypersensitivity to nitrates.
- Hypotension, hypovolemia, severe anemia.
- Cerebral hemorrhage, brain trauma.
- Mitral stenosis, HOCM-related angina.
- Concurrent use of phosphodiesterase inhibitors.
✔️ Precautions
- Avoid alcohol after administration.
- Do not use concurrently with sildenafil, vardenafil, or tadalafil due to the risk of severe hypotension, syncope, or fatal cardiovascular events.
- Not intended for continuous daily use.
- Keep out of reach of children.
✔️ Use in Pregnancy & Lactation
- Pregnancy Category C: Use only if necessary.
- Excretion in breast milk is unknown—exercise caution during lactation.
✔️ Storage
Store in a cool, dry place, protected from heat and light. Keep out of children's reach.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
