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Nitrocontin 6.4mg (25pcs Pot)
Nitrocontin is used for the prevention of angina pectoris (chest pain due to heart-related causes). It is not suitable for the treatment of acute anginal attacks due to its delayed onset of action.
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✅ Description:
- Nitroglycerin exerts its effect by relaxing vascular smooth muscles, leading to vasodilation of both arteries and veins.
- Venous dilation reduces venous return to the heart, lowering preload and left ventricular end-diastolic pressure.
- Arterial dilation decreases systemic vascular resistance and afterload, reducing the heart’s oxygen demand.
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✔️ Dosage & Administration
Dosage should be tailored to individual patient response and the severity of anginal symptoms.
Adults: One 2.6 mg sustained-release tablet or capsule in the morning and evening, preferably on an empty stomach.
✔️ Side Effects
- Headache (common at the start, often transient)
- Tachycardia, postural hypotension, syncope
- Rare: Cyanosis, methaemoglobinaemia
✔️ Drug Interactions
- Potentiates antihypertensive effects of vasodilators, calcium channel blockers, and beta-blockers.
- Aspirin may enhance hemodynamic effects and reduce the clearance of nitroglycerin.
- May reduce the efficacy of heparin when given together.
- Increases the bioavailability of dihydroergotamine.
- Risk of severe hypotension when combined with:
- Phosphodiesterase type-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
- Tricyclic antidepressants (TCAs) and alcohol
✔️ Nitrocontin is contraindicated in patients with:
- Allergy to nitroglycerin, organic nitrates, or excipients
- Acute myocardial infarction
- Marked anaemia
- Head trauma or cerebral hemorrhage
- Closed-angle glaucoma
✔️ Pregnancy & Lactation
- Safety during pregnancy and breastfeeding is not well established.
- Use only if clearly necessary and prescribed by a physician.
✔️ Precautions & Warnings
Use cautiously in patients at risk of closed-angle glaucoma.
- Do not stop treatment abruptly; taper dose gradually under supervision to avoid rebound angina.
- In acute MI, careful hemodynamic monitoring is essential to avoid hypotension and reflex tachycardia.
✔️ Storage Conditions
- Store in a cool, dry place, protected from heat and light.
- Keep out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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