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Profenid-E is used for its anti-inflammatory, analgesic, and antipyretic properties. It is indicated for the symptomatic treatment of:
- Rheumatoid arthritis
- Degenerative joint diseases
- Musculoskeletal and joint disorders such as tendinitis and sprains
- Pain from various origins, such as dental pain, headache, and primary dysmenorrhea
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✅ Description:
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. It works by inhibiting prostaglandin synthesis and stabilizing lysosomal membranes. Additionally, it inhibits leukotriene synthesis at high concentrations and exhibits antibradykinin activity. Ketoprofen provides pain relief by blocking prostaglandin synthesis both centrally and peripherally. It may also suppress prostaglandin synthesis in the central nervous system, particularly in the hypothalamus, to exert its antipyretic effect.
Ketoprofen is absorbed rapidly from the gastrointestinal tract and is highly protein-bound (approximately 99%). Its elimination half-life is 1.1 to 4 hours and is primarily metabolized in the liver through conjugation with glucuronic acid. Most of the drug is excreted via urine (50–90%) and feces (1–8%) within 1–5 days. After intramuscular injection, the peak concentration is reached within 0.5 to 0.75 hours.
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✔️ Side Effects
Possible side effects include:
- Common: Nausea, dyspepsia, vomiting, abdominal pain
- Uncommon: Rash, pruritus, dizziness, diarrhea
- Rare: Vision problems, tinnitus, or peptic ulcers
- Unknown frequency: Hypertension, heart failure, liver dysfunction, renal impairment, and severe skin reactions
✔️ Dosage
- For anti-inflammatory purposes: Start with 150–300 mg daily, divided into three doses. Maintenance dosage ranges from 100–200 mg daily, which may be administered twice daily or as a single daily dose. The maximum daily dose is 300 mg.
- For pain and primary dysmenorrhea: Take 25–50 mg every 6–8 hours as needed, not exceeding 300 mg per day.
✔️ Administration
Oral forms should be taken with fluids, preferably alongside food.
✔️ Drug Interactions
Not recommended:
- NSAIDs (including COX-2 inhibitors) and high-dose salicylates increase the risk of gastrointestinal ulcers and bleeding.
- Anticoagulants, heparin, and platelet aggregation inhibitors increase bleeding risk.
- Lithium co-administration may raise lithium plasma levels to toxic levels.
- Methotrexate (doses >15 mg/week) may increase the risk of hematologic toxicity.
✔️ Use with precautions:
- Drugs promoting hyperkalemia (e.g., potassium salts, ACE inhibitors, diuretics) increase hyperkalemia risk.
- Corticosteroids increase the risk of gastrointestinal complications.
- Diuretics and ACE inhibitors may compromise renal function.
- Cyclosporine and tacrolimus may increase nephrotoxicity.
✔️ Profenid-E should not be used in:
- Patients with hypersensitivity to ketoprofen, aspirin, or other NSAIDs
- Severe heart failure, liver impairment, or kidney impairment
- Active or history of peptic ulcers, gastrointestinal bleeding, or perforation
- During the third trimester of pregnancy
- Patients with rectal conditions (for rectal formulations)
✔️ Pregnancy & Lactation
- During the first and second trimesters, the use of ketoprofen should be avoided unless necessary.
- Contraindicated during the third trimester due to potential fetal risks.
- Not recommended during breastfeeding.
✔️ Precautions
- Use cautiously in patients with gastrointestinal disorders, renal or hepatic impairment, hypertension, or heart failure.
- Monitor renal function in elderly patients or those with dehydration.
- NSAIDs may mask signs of infection, such as fever.
- May impair female fertility; withdrawal is recommended for women trying to conceive.
✔️ Storage
Store below 30°C, away from light, and out of reach of children. Use only as prescribed by a registered physician. Avoid using beyond the expiry date.
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