Purifen 200mg (30pcs Box)

Indications of Purifen Tablet

Purifen Tablet is used for the treatment of osteoarthritis signs and symptoms.

• Rheumatoid illnesses such as osseous rheumatism, ankylosing spondylitis, juvenile arthritis, muscular rheumatism, and degenerative joint diseases are all treated with this drug.
• Treatment of painful menstruation as a symptom (primary dysmenorrhoea)
• Fever and a common headache
• Treatment of mild to moderate pain, such as muscular discomfort, headaches, and tooth pain, on a symptomatic basis.
• As an adjuvant for headaches caused by the common cold and influenza.

Pharmacology of Purifen Tablet

Dextroibuprofen (S (+) ibuprofen) is considered the pharmacologically active enantiomer of racemic ibuprofen. Like racemic ibuprofen, dextroibuprofen is a non-steroidal anti-inflammatory drug with analgesic effect. Like ibuprofen, dextroibuprofen works by inhibiting prostaglandin synthesis.

Pharmacokinetics: Dextroibuprofen is absorbed primarily from the small intestine. After metabolic conversion (hydroxylation, carboxylation) in the liver, pharmacologically inactive metabolites are completely excreted, mainly through the kidneys (90%), but also in the bile. The elimination half-life is 1.83.5 hours; the plasma protein binding rate is about 99%. Peak plasma levels are reached approximately 2 hours after oral administration. Taking dexibuprofen with meals delays the time to peak concentration (from 2.1 hours after fasting to 2.8 hours after non-fasting) and reduces the peak plasma concentration (from 20.6 to 18.1 mcg/ml, which is not clinically relevant). , But has no effect on the degree of absorption.

Purifen Tablet Dosage & Administration

The dosage must be adjusted to the seriousness of the syndrome and the complaints of the patient. During chronic pain, the dosage must be adapted to the lowest effective dose.

The recommended dosage: is 600-900 mg of Dexibuprofen per day, at 2-3 divided doses. The dosage can be raised temporarily up to 1200 mg Dexibuprofen per day in patients with acute disorders or exacerbations. The maximum daily dose is 1200 mg.

For dysmenorrhea: A dosage of 600 up to 900 mg Dexibuprofen per day, at a divided dose.

Interaction

Dexibuprofen's documented medication interactions are comparable to those of a racemic combination of ibuprofen. Anticoagulants, hydantoine and sulfonamide, ticlopidine, lithium, other NSAIDs, ACE inhibitors, beta blockers, cyclosporine, tacrolimus, corticosteroids, digoxin, methotrexate, pentoxyfiline, phenytoine, probenecid, sulfinpyrazon, sulfonylurea, thiazide and thiazide

Contraindications

Patients having a history of hypersensitivity to Dexibuprofen, another NSAID, or any other component of the product should avoid using it. After using comparable medications (e.g. aspirin or other NSAIDs), patients who have asthma attacks have bronchospasm, acute rhinitis, urticaria, or edema. Patients with actual or suspected bleeding, Crohn's disease or ulcerative colitis, severe cardiac illness, renal function impairment (GFR 30ml/min), and liver function impairment are also prohibited.

Side Effect

Dexibuprofen's side effects are comparable to those of racemic ibuprofen, according to clinical experience. Dyspepsia, diarrhea, tiredness, headache, nausea, vomiting, stomach discomfort, hypersensitivity responses - bleeding, and ulcers are all common adverse effects.

Pregnancy & Lactation

Patients having a history of hypersensitivity to Dexibuprofen, another NSAID, or any other component of the product should avoid using it. After using comparable medications (e.g. aspirin or other NSAIDs), patients who have asthma attacks have bronchospasm, acute rhinitis, urticaria, or edema. Patients with actual or suspected bleeding, Crohn's disease or ulcerative colitis, severe cardiac illness, renal function impairment (GFR 30ml/min), and liver function impairment are also prohibited.

Precautions & Warnings

For patients suffering from bronchial asthma or other chronic lung diseases and those who are prone to allergies, dextroibuprofen should be used with special caution. This medication is used in patients with hypertension who have liver, kidney, or heart failure and who have not responded to any treatment. For patients with systemic lupus or other autoimmune diseases, it is recommended to consult a doctor before starting treatment with this medicine. In the case of active and suspected bleeding disorders such as gastroduodenal ulcer, ulcerative colitis, Crohn's disease, alcoholism, etc., dextroibuprofen should be used with extreme caution. Even the first time you use it, you may experience an allergic reaction to the medicine. In this case, you should stop using it immediately.

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children