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Todol 10mg Tablet 14pcs
Todol is indicated for:
- Short-term management of moderate to severe acute post-operative pain.
- Ophthalmic use: Relieves pain, inflammation, and light sensitivity following ocular surgery.
- It is also used to decrease eye inflammation or redness caused by seasonal allergies.
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✅ Description:
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✔️ Description:
Todol belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs). Chemically, it is known as 5-benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol.
- Mechanism of Action: Todol inhibits the cyclooxygenase (COX) enzyme system, which reduces prostaglandin synthesis. This action helps alleviate pain and inflammation but with minimal anti-inflammatory effects at analgesic doses.
- Pharmacokinetics: The drug is highly protein-bound and is metabolized in the liver. Both metabolized products and some unchanged drugs are excreted via urine.
- Biological Activity: The S-form of Todol is responsible for its biological effect. The drug's pharmacokinetic properties are linear.
✔️ Dosage & Administration
- Recommended dose: 10 mg every 4-6 hours.
- Limit use to short-term (up to 7 days); avoid long-term use.
- Do not exceed 40 mg/day.
✔️ Common side effects include:
- Nausea, vomiting
- Gastrointestinal bleeding, peptic ulcer
- Anxiety, drowsiness, headache
- Fatigue, excessive thirst
- Hypertension, chest pain, bradycardia
- Pulmonary edema, infertility in females
✔️ Interactions
- Other NSAIDs or aspirin: Increased side effects of Todol.
- Anti-coagulants: Enhanced anticoagulant effect.
- Beta Blockers: Reduced antihypertensive effect.
- ACE Inhibitors: Increased risk of renal impairment.
- Methotrexate: Enhanced methotrexate toxicity.
✔️ Contraindications
- Hypersensitivity to Ketorolac or other NSAIDs.
- Children under 16 years of age.
- Prophylactic analgesic use before surgery.
✔️ Pregnancy & Lactation
- FDA Pregnancy Category C: Should be avoided during pregnancy and lactation unless benefits outweigh risks.
- Ketorolac may pose risks to the fetus; consult a healthcare professional before use.
✔️ Precautions & Warnings
- Use caution in patients over 65 years of age.
- Patients with active peptic ulcers, gastrointestinal bleeding, asthma, or liver dysfunction should take Todol with caution.
- Eye Drops: Discontinue use if corneal epithelial breakdown occurs. Avoid use while wearing contact lenses.
✔️ Storage Conditions
- Keep in a dry place away from light and heat.
- Keep out of the reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
