Tablet (50 pcs = 1 Box)
Manufacturer/Distributor: Novartis (Bangladesh) Ltd.
Generic Name: Diclofenac 75 mg Tablet
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Indications of Voltalin SR 75
Rheumatology: inflammatory and degenerative forms of rheumatism, degenerative chronic polyarthritis, ankylosing spondylitis, osteoarthritis, spondyloarthropathy, acute gout, rheumatic diseases around the joints.
Surgery and Traumatology: Sprains, contusions, dislocations, fractures, soft tissue injuries, surgical procedures.
Department of Obstetrics and Gynecology: Primary dysmenorrhea, episiotomy, adnexitis, endometritis, parauterine inflammation, salpingitis and mastitis.
Department of Otolaryngology - As a medicine to prevent pain, inflammation, and swelling before surgery.
Dentistry: pain, inflammation and swelling after surgery and trauma.
Other indications: used for pain prevention and treatment of inflammation and swelling in patients undergoing genitourinary tract, renal and biliary colic surgery.
Pharmacology
Diprofen sodium is an effective non-steroidal anti-inflammatory drug (NSAID) with significant anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties. It also has a certain effect of promoting uric acid excretion. Diclofenac exerts its effect by inhibiting the biosynthesis of prostaglandins, which play an important role in causing inflammation, pain and fever. Diclofenac is quickly and completely absorbed from the gastrointestinal tract when taken or taken after meals. The peak plasma concentration is reached on average 2 hours after ingestion. At therapeutic concentrations, its binding rate to plasma proteins is 99.7%. Diclofenac is metabolized in the liver and undergoes first-pass metabolism.
Dosage & Administration
Diclofenac FC Tablet: Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food. Dose should be reduced in long term use.
Diclofenac SR Tablet:
Adult: 1 tablet daily, taken whole with liquid, preferably at meal times. If necessary, the daily dose can be increased to 150 mg by supplementation with conventional tablets.
Children: 1-3 mg of diclofenac/kg body wt. daily in divided doses.
Elderly patients: In elderly or debilitated patients, the lowest effective dosage is recommended, although the pharmacokinetics of diclofenac sodium is not impaired to any clinically relevant extent in elderly patients.
Diclofenac Dispersible Tablet:
Adults: The recommended daily dosage is 2-3 tablets and the maximum daily dose is 150 mg. In milder cases, 2 tablets of Diclofenac DT per day are sufficient. Diclofenac DT should preferably be taken before meals.
Children: Diclofenac is not recommended in children for other indications except juvenile rheumatoid arthritis where the recommended dose is 1-3 mg/kg body weight. Diclofenac DT is to be dropped into a half-glass of water and the liquid is to be stirred to aid dispersion before swallowing. There is no information on the use of Diclofenac DT for more than 03 months.
Diclofenac TR Capsule: One capsule daily. Diclofenac TR should be taken preferably after mealtimes.
Diclofenac Suppository: For adults: 50 mg suppository 2-3 times daily. Maximum daily dose is 150 mg.
Diclofenac injection: For adults the usual dose is 1 ampoule daily. In serious cases this dose may be increased up to 2 ampoules daily.
Diclofenac Gel: For external use only. Depending on the size of area to be treated, 2-4 g of Diclofenac gel should be applied to the skin 3-4 times daily. To the affected area gel should be rubbed in lightly. This gel may also be given in addition to further treatment with other dosage forms of Diclofenac.
Contraindications
Patients allergic to any component of this product are contraindicated. Peptic ulcers, like other non-steroidal anti-inflammatory drugs, are allergic to diclofenac, which is also contraindicated in asthma, hives, or acute rhinitis caused by aspirin or other drugs containing prostaglandin synthase inhibitors. This gel should not be used under closed airtight dressings.
Side Effects of Voltalin SR 75
Patients allergic to any component of this product are contraindicated. Peptic ulcers, like other non-steroidal anti-inflammatory drugs, are allergic to diclofenac, which is also contraindicated in asthma, hives, or acute rhinitis caused by aspirin or other drugs containing prostaglandin synthase inhibitors. This gel should not be used under closed airtight dressings.
Pregnancy
Diclofenac should only be used for overriding reasons during pregnancy. The lowest effective dose should be used. During the first trimester of pregnancy, these types of drugs are not recommended. In view of the lack of clinical data, diclofenac sodium gel is not recommended during pregnancy. A very significant amount of diclofenac can be detected in breast milk, but it is expected that it will have no adverse effects on the infant.
Precautions
In rare instances where peptic ulceration or gastrointestinal bleeding occurs in patients under treatment with Diclofenac. In patients with advanced age should be kept under close observation. Diclofenac Sodium Gel should not be allowed to come in contact with the eyes or mucus membranes, after application the hands should be washed properly and not to be taken by mouth.
Therapeutic Class
Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children.
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