Voltalin Suppository 25mg 1pc

✔️ Uses of Voltalin Suppository 25mg

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Pain
• Migraine
• Dysmenorrhea
• Muscle aches
• Acute gout
• Inflammation
• Renal colic
• Tendinitis
• Backaches
• Dental pain
• Menstrual cramps
• Bursitis

✔️ Mode of Action:

• Diclofenac, a phenylacetic acid derivative, is a prototypical NSAID.
• Potent anti-inflammatory, analgesic, and antipyretic actions.
• Reversibly inhibits the enzyme cyclooxygenase, resulting in reduced synthesis of prostaglandin precursors.

✔️ How does Voltalin Suppository 25mg work?

It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).

✔️ Side Effects of Voltalin Suppository 25mg

• Gastrointestinal irritation and bleeding are potential side effects.
• Skin irritation, reddening, and rash may occur with topical gel use.

✔️ Quick Suggestions:

• You have been prescribed Diclofenac to relieve pain and inflammation.
• Take it with food or milk to prevent an upset stomach.
• Take it as per the dose and duration prescribed by your doctor. Long-term use may lead to serious complications such as stomach bleeding and kidney problems.
• It may cause dizziness, drowsiness, or visual disturbances. Use caution while driving or doing anything that requires concentration.
• Avoid consuming alcohol while taking Diclofenac as it can cause excessive drowsiness and increase your risk of stomach problems.
• Inform your doctor if you have a history of heart disease or stroke.
• Your doctor may regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

✔️ Pharmacology

• Diclofenac sodium inhibits prostaglandin production.
• It is swiftly and thoroughly absorbed from the gastrointestinal tract, with peak plasma concentrations reached in about 2 hours.
• It is highly protein-bound (99.7%) and undergoes hepatic metabolism.

✔️ Dosage & Administration of Voltalin Suppository 25mg

Diclofenac Suppository: For adults: 50 mg suppository 2-3 times daily. The maximum daily dose is 150 mg.

✔️ Interaction

• Methotrexate: Diclofenac may increase serum levels of methotrexate, potentially leading to methotrexate toxicity. Close monitoring of methotrexate levels and adjustment of dosage may be necessary.
• NSAIDs and Anticoagulants (e.g., warfarin): Concomitant use of diclofenac with other NSAIDs or anticoagulants like warfarin increases the risk of gastrointestinal bleeding. Caution is advised, and patients should be monitored for signs of bleeding.
• Ciclosporin or Triamterene: Diclofenac may increase the risk of nephrotoxicity when used concurrently with ciclosporin or triamterene. Renal function should be closely monitored in patients receiving this combination.
• Ophthalmic Preparations Containing Corticosteroids: Concurrent use of diclofenac with ophthalmic preparations containing corticosteroids may increase the risk of corneal complications, particularly in patients with pre-existing corneal inflammation. Caution is advised, and patients should be monitored for adverse effects.
• Colestyramine and Colestipol: These agents may reduce the bioavailability of diclofenac. Administration of diclofenac should be separated from these bile acid sequestrants to avoid decreased efficacy.
• Sucralfate: Administration of diclofenac after sucralfate may decrease its plasma concentration. To avoid reduced efficacy, diclofenac should be administered at least two hours before or after sucralfate.
• Ophthalmic Acetylcholine and Carbachol: Topical application of diclofenac may reduce the efficacy of ophthalmic acetylcholine and carbachol. Caution is advised when using these medications concomitantly.
• Lithium and Digoxin: Diclofenac may increase serum levels of lithium and digoxin. Monitoring of lithium and digoxin levels and adjustment of dosage may be necessary when used concomitantly with diclofenac.

✔️ Contraindications

• Contra-indicated for patients hypersensitive to Diclofenac.
• In patients with active or suspected peptic ulcer or gastrointestinal bleeding.
• Contraindicated for patients in whom attacks of asthma, urticaria, or acute rhinitis are precipitated by aspirin or other NSAIDs.
• Contraindicated for patients hypersensitive to local anesthetics of the amide-type.

✔️ Pregnancy & Lactation

• Diclofenac should be used with caution during pregnancy, particularly avoiding the first trimester.
• The use of diclofenac gel during pregnancy is not recommended due to limited clinical data.
• Diclofenac is excreted in breast milk but is generally considered safe for breastfeeding.

✔️ Precautions & Warnings

• Monitoring for peptic ulcers and gastrointestinal bleeding is recommended, especially in elderly patients.
• Avoid contact with eyes or mucous membranes when using diclofenac gel.
• Proper hand hygiene is important after applying diclofenac gel to prevent unintentional ingestion.

✔️ Storage Conditions

Store in a cold, dry, and light-protected location. Keep it below 30°C. Keep out of children's reach.