Amantadine Hydrochloride manages Parkinson’s disease by enhancing muscle control and decreasing stiffness, tremors, and unsteady movements. Alleviates shingles (herpes zoster) pain. Prevents and addresses multiple strains of influenza A virus. Addresses drug-induced extrapyramidal reactions.
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Mantadin 100mg Capsule contains Amantadine, classified as a Dopamine agonist and Anti-viral agent. It is prescribed for Parkinson’s disease, alleviating symptoms like tremors and muscle stiffness, and for preventing and treating various strains of influenza A virus. Additionally, it's used to reduce pain in shingles and to counteract drug-induced extrapyramidal reactions caused by certain medications.
Before commencing Mantadin 100mg Capsule, disclose any kidney, liver, heart issues, mental illnesses like schizophrenia or dementia, and glaucoma to your doctor. Avoid Mantadin 100mg Capsule during pregnancy or breastfeeding. It's not recommended for newborns, or infants below 1 year, and should be taken cautiously by elderly patients (65 or older). Discuss with your doctor before usage.
Common side effects include appetite loss, fatigue, dry mouth, constipation, and nausea or vomiting. If these side effects worsen, consult your doctor.
Do not drink alcohol while taking Mantadin 100mg Capsule as it may cause dizziness, confusion, lightheadedness, and low blood pressure (especially when standing up from sitting or lying position).
Mantadin 100mg Capsule is not recommended to be taken while you are pregnant. Consult your doctor before taking Mantadin 100mg Capsule if you are pregnant or planning to have a baby.
Mantadin 100mg Capsule is not recommended to be taken while you are breastfeeding as it may pass through breast milk and could harm the baby. Consult your doctor before taking Mantadin 100mg Capsule.
Do not drive or use machines after taking Mantadin 100mg Capsule as it may cause side effects such as dizziness or visual disturbances that may affect your ability to drive and use machines. Consult your doctor before taking Mantadin 100mg Capsule.
Mantadin 100mg Capsule should not be used in patients with serious kidney disease. It should be used with caution in patients with kidney disease. Consult with your doctor for advice before taking Mantadin 100mg Capsule.
[GBNKWYWORD] should be taken with caution if you have any liver disease. Consult with your doctor before taking Mantadin 100mg Capsule.
Mantadin 100mg Capsule is a dual-action medication that functions as both a dopamine agonist for treating Parkinson's disease and an antiviral agent against certain viral infections. By elevating dopamine levels in the brain, it enhances motor control and mitigates Parkinson's symptoms. Simultaneously, it inhibits viral growth and reproduction, preventing the release of infectious viral components, thus thwarting influenza infection.
AMANTADINE contains amantadine, a dopamine agonist that serves as an anti-Parkinson's medication. Its mechanism involves elevating dopamine levels in the brain, a crucial chemical responsible for enhancing the coordination of body movements. This effect contributes to improved daily functioning and an enhanced quality of life for individuals with Parkinson's disease. Notably, Parkinson's disease is more prevalent among men.
Amantadine's exact mechanism for its antiviral effects remains unknown. However, it interferes with the viral M2 protein's transmembrane domain, primarily hindering the release of infectious viral nucleic acid into host cells. Additionally, Amantadine can inhibit viral assembly during virus reproduction under specific conditions. Its impact on the immunogenicity of inactivated influenza A virus vaccines is minimal.
Amantadine effectively prevents replication of influenza A virus isolates across all subtypes, including H1N1, H2N2, and H3N2. However, it demonstrates limited or no activity against anti-influenza B viral isolates. While in vitro studies have shown varying results regarding Amantadine's effectiveness against influenza A, no clear link has been established between in vitro susceptibility and clinical response. The dose required to suppress viral growth by 50% (ED50) varies widely (0.1 g/mL to 25.0 g/mL) based on assay techniques, virus strains, and cell types used.
Dosages for various conditions:
Parkinson's disease:
Prophylaxis of Influenza A:
Influenza A:
Herpes zoster in immunocompromised patients:
Note: Due to resistance, amantadine is no longer recommended for influenza prophylaxis or treatment.
When taking Mantadin 100mg Capsules:
If you are allergic to amantadine or to any of the other ingredients of Mantadin 100mg Capsules.
Category C pregnancy. There has been no well-controlled research on Mantadin's safety in pregnant women. When the possible advantages outweigh the unknown dangers to the fetus, amantadine may be administered during pregnancy.
Low levels of amantadine are excreted in breast milk. Because there is no evidence on the effects of amantadine on babies, it should be taken with caution in women who are nursing.
Consult your doctor if:
When discontinuing Mantadin 100 in Parkinson's disease patients, avoid abrupt cessation as it can lead to a Parkinsonian crisis. If combined with anticholinergic drugs, adjust the doses to avoid atropine-like symptoms. Abrupt cessation can cause side effects like delirium, agitation, hallucinations, depression, and speech difficulties. Always consult your doctor before making any changes to your medication.
Store Mantadin 100mg Capsule below 30ºC in a cool and dry place, away from direct sunlight. Keep out of reach of children and pets.
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