Syndopa CR 125 | Antiparkinsonian Drugs | ePharma
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Syndopa CR 125mg Tablet 10pcs

Generic: Carbidopa + Levodopa

Type: Tablet

Pack Size: 10 Pcs

Syndopa CR 125mg Tablet is a combination medication used to treat Parkinson’s disease, relieving symptoms such as tremors, muscle stiffness, and difficulty in movement. It should be taken consistently at the same time each day, with or without food, but high-protein meals should be avoided. Follow your doctor's prescribed dosage, and do not stop the medication abruptly without medical advice.


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Discount Price: ৳ 95.29
MRP: ৳ 100.3 5% Off

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✅ Description:

Levodopa is the metabolic precursor of dopamine and crosses the blood-brain barrier to be converted to dopamine in the brain. Carbidopa is a dopa decarboxylase (DDC) inhibitor that reduces the peripheral metabolism of levodopa to dopamine, thereby increasing the availability of levodopa in the brain.

Titration Following initiation, doses, and intervals may be adjusted based on therapeutic response. Typical dosing ranges from two to eight tablets per day, divided into doses every 4 to 12 hours. An interval of at least three days between dosage adjustments is recommended.

Maintenance Periodic clinical evaluations are recommended to adjust the dosage regimen. Additional antiparkinson medications like anticholinergics, dopamine agonists, and amantadine can be added.

Safety Advices


Alcohol
UNSAFE

Unsafe to consume with Syndopa CR 125.


Pregnancy
UNSAFE

Potentially unsafe; consult your doctor due to limited human studies but harmful animal study results.


Breastfeeding
CONSULT YOUR DOCTOR

Breastfeeding is probably safe but may cause partial or complete suppression of lactation.


Driving
CAUTION

 It may impair ability due to dizziness, drowsiness, or double vision.


Kidney
CONSULT YOUR DOCTOR

No significant dose adjustment is needed but consult your doctor.


Liver
SAFE IF PRESCRIBED

Use with caution; dosage adjustment may be necessary.

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✔️ Uses of Syndopa CR 125mg Tablet
  • Parkinson's disease
✔️ How does Syndopa CR 125mg Tablet work?
  • Levodopa: Converts to dopamine in the brain, improving movement control.
  • Carbidopa: Prevents the breakdown of levodopa in the body, ensuring more reaches the brain.
✔️ Side Effects of Syndopa CR 125mg Tablet

Common side effects include dyskinesia, nausea, hallucinations, confusion, dizziness, and dry mouth. Severe side effects can include neuroleptic malignant syndrome, orthostatic hypotension, and cardiac irregularities.

✔️ Quick Suggestions:
  • Adhere to the prescribed schedule for consistent medication levels in the body.
  • Rise slowly from sitting or lying positions to avoid dizziness or lightheadedness.
  • Be cautious with activities requiring alertness, such as driving, due to potential drowsiness.
✔️ Indication of Syndopa CR 125mg Tablet

Levodopa-Carbidopa prolonged-release tablets are indicated for the treatment of idiopathic Parkinson's disease, particularly to reduce "off" periods in patients who have been previously treated with levodopa/decarboxylase inhibitors or with levodopa alone and have experienced motor fluctuations.

✔️ Pharmacology

According to current data, symptoms of Parkinson's disease are linked to dopamine depletion in the corpus striatum. Dopamine's metabolic precursor, levodopa, crosses the blood-brain barrier and is likely converted to dopamine in the brain. Carbidopa prevents peripheral levodopa from being decarboxylated.
Because carbidopa's decarboxylase inhibitory effect is limited to extracerebral tissues, combining it with levodopa increases the amount of levodopa accessible for delivery to the brain.

✔️ Dosage & Administration of Syndopa CR 125mg Tablet

Dosage For patients currently treated with conventional levodopa/decarboxylase inhibitor combinations, the dosage with Levodopa-Carbidopa prolonged-release tablets should initially provide no more than approximately 10% more levodopa per day, with the dosing interval extended by 30 to 50%, ranging from 4 to 12 hours. Dosages up to 30% more levodopa per day may be necessary. Conversion guidelines from conventional to prolonged-release tablets are provided.

Administration Patients currently on levodopa alone should discontinue levodopa at least eight hours before starting the CR tablet. For those with mild to moderate disease not previously treated with levodopa, the initial dose is one CR tablet twice daily, not exceeding 600 mg of levodopa per day.

✔️ Interaction

Caution is needed when administering Levodopa-Carbidopa with antihypertensive agents, antidepressants, anticholinergics, iron supplements, and other drugs that may interact with levodopa or carbidopa.

✔️ Contraindications

Levodopa-Carbidopa prolonged-release tablets are contraindicated in patients with hypersensitivity to any component, narrow-angle glaucoma, and those treated with non-selective monoamine oxidase inhibitors. It is also contraindicated in patients with undiagnosed skin lesions or a history of melanoma.

✔️ Pregnancy & Lactation

There is insufficient data on the use of Levodopa-Carbidopa in pregnancy. It should not be used during pregnancy or lactation.

✔️ Precautions & Warnings

Care is required when administering to patients with severe cardiovascular or pulmonary disease, peptic ulcer history, or convulsions. Levodopa has been associated with sleepiness and sudden sleep onset; patients must be cautious about driving or operating machinery. Behavioral monitoring is recommended due to potential impulse control disorders.

✔️ Storage Conditions:

Store in a cold, dry, and light-protected location.

Frequently Asked Questions (FAQ)

No, taking a higher dose than recommended can increase the risk of side effects and toxicity. If your symptoms do not improve after a few weeks, or if the medication's effects wear off quickly between doses, consult your doctor for advice.

Levodopa+Carbidopa controls Parkinson's disease symptoms but does not cure the condition. It may take several months to feel the full benefit of the medication.

Store this medicine in its original container, tightly closed, and according to the instructions on the pack or label. Dispose of unused medicine properly, ensuring it is not consumed by pets, children, or other people.

Yes, it is a rare side effect. Levodopa+Carbidopa may alter the color of your saliva, urine, or sweat, making them red, brown, or black. This is harmless, but it can stain your clothing.

Yes, Levodopa+Carbidopa can cause drowsiness or sudden sleep onset during daily activities. You might not feel drowsy or notice warning signs before suddenly falling asleep. Avoid driving, operating machinery, or engaging in potentially dangerous activities until you know how the medication affects you. If you suddenly fall asleep or become very drowsy during the day, contact your doctor.

No, you should continue taking Levodopa+Carbidopa even if you feel well. Do not stop the medication without consulting your doctor, as sudden discontinuation can cause serious problems like fever, rigid muscles, unusual body movements, and confusion. If your symptoms are relieved, your doctor might gradually decrease your dose.

Levodopa+Carbidopa is a combination medication used to treat symptoms of Parkinson's disease such as tremors, stiffness, and slow movement. Levodopa converts to dopamine in the brain, while Carbidopa prevents the breakdown of Levodopa before it reaches the brain. This combination increases dopamine levels, helping control Parkinson’s symptoms and improving daily activities like dressing, walking, and handling utensils.
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Check our pricing section for Syndopa CR 125mg Tablet 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.

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