Dapoxetine treats PE by inhibiting serotonin reuptake, enhancing its action at nerve receptors involved in the ejaculation reflex, which is controlled by the brain and spinal cord. It is rapidly absorbed (peak in 1–2 hrs), 42% bioavailable, and highly protein-bound. It is extensively metabolized and eliminated mainly via urine, with a half-life of about 19 hours.
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Daporex is prescribed for men aged 18–64 with premature ejaculation (PE) who experience one or more of the following: persistent or recurrent ejaculation with minimal stimulation before or soon after penetration, marked distress or relationship issues due to PE, and poor control over ejaculation. (Take only under a registered physician’s advice.
Common—nausea, dizziness, dry mouth, headache, diarrhea, insomnia. Rarely—loss of libido or erectile dysfunction.
Adults (18–64): Start with 30 mg taken 1–3 hours before sexual activity; may increase to 60 mg if needed and well-tolerated. Maximum: once in 24 hrs. Take with or without food. Not for under 18s or those 65+. Use caution in mild/moderate kidney disease; avoid in severe kidney or liver impairment.
Use with caution alongside CNS-active drugs, PDE5 inhibitors (e.g., sildenafil, tadalafil), alpha-blockers (e.g., tamsulosin), warfarin, and alcohol (increases risk of dizziness, fainting). Avoid combining with recreational drugs, serotonergic agents, MAOIs, or thioridazine.
Hypersensitivity to dapoxetine, significant heart disease, use of MAOIs, thioridazine, SSRIs/SNRIs/TCAs, or serotonergic herbal products within the specified washout periods.
May cause syncope or orthostatic hypotension—orthostatic test recommended before starting. Caution in bleeding disorders or with anticoagulants/antiplatelets. Avoid alcohol and certain recreational drugs due to increased adverse effects.
Store below 30°C, protected from light and moisture, out of children’s reach.
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