Azathioprine is used for preventing organ rejection in transplant patients, treating rheumatoid arthritis, and managing autoimmune diseases.
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Imruza 25, containing azathioprine as its active ingredient, is prescribed for the treatment of organ transplants and certain autoimmune diseases. Azathioprine works by reducing the strength of the immune system.
It is crucial to use contraceptive methods while taking Azathioprine Tablets and for up to 3 months after completing the course of treatment, as the medication may pose risks during pregnancy. Therefore, it is advised to avoid Azathioprine Tablets if you are pregnant or breastfeeding.
Additionally, excessive exposure to sunlight should be avoided while on Azathioprine Tablets. It is recommended to wear protective clothing and use sunscreen with a high protection factor to minimize the risk of skin damage.
Avoid consumption of alcohol while taking Imruza 25. Consult your doctor before taking it.
Imruza 25 is not recommended for use in pregnant women unless considered necessary. Consult your doctor before taking it.
Imruza 25 is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
Do not drive or operate any machines if you feel dizzy after taking Imruza 25. Consult your doctor before taking it.
Imruza 25 should be taken with caution in patients with kidney problems. Consult your doctor before taking it.
Imruza 25 is not recommended for use in patients with severe liver disease. Consult your doctor before taking it.
Imruza inhibits DNA, RNA, and protein synthesis, suppressing the body's immune response. It also blocks certain chemical messengers responsible for inflammation in joint diseases.
Imruza (azathioprine) is an immunosuppressant medication used either alone or in combination with other agents, such as corticosteroids, to influence the immune response.
Imruza has been used with clinical benefit in conditions like severe active rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, polymyositis, autoimmune chronic active hepatitis, pemphigus vulgaris, polyarteritis nodosa, autoimmune hemolytic anemia, and chronic refractory idiopathic thrombocytopenic purpura.
For organ transplant recipients, the initial dosage of Azathioprine may vary depending on the specific immunosuppressive regimen employed, but it can be up to 5 mg/kg of body weight per day, administered orally or intravenously on the first day of therapy. Maintenance dosages typically range from 1 to 4 mg/kg of body weight per day and should be adjusted based on clinical requirements and hematological tolerance. It's generally recommended to continue Azathioprine therapy indefinitely, even at low doses, to reduce the risk of organ rejection.
For other indications such as inflammatory bowel disease (IBD), the starting dosage is typically between 1 to 3 mg/kg of body weight per day. The maintenance dosage can be adjusted within this range based on the clinical response and hematological tolerance of the individual patient. If there's no improvement in the patient's condition within three months, discontinuation of Azathioprine should be considered. However, for patients with IBD, treatment should typically continue for at least twelve months, as the response to treatment may not be clinically apparent until after three to four months.
Dosage adjustments may be necessary for certain patient populations:
Imruza 25 is administered orally and should be taken at least 1 hour before or 2 hours after consuming milk or dairy products.
Here are some important drug interactions to be aware of when taking Imruza 25:
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