Azathioprine belongs to the class of cytotoxic immunosuppressants and acts as an immunosuppressive antimetabolite by antagonizing purine metabolism.
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Imruza 50mg Tablet is utilized as an immunosuppressant antimetabolite, either alone or in combination with other agents such as corticosteroids, and procedures that affect the immune response. Its therapeutic effects may take weeks or months to become evident and can include a steroid-sparing effect, thereby reducing the toxicity associated with high doses and prolonged usage of corticosteroids.
It is indicated for:
It is not known whether it is safe to consume alcohol with Imruza 50. Consult your doctor.
Imruza 50 is unsafe to use during pregnancy due to the risk of harm to the developing baby. However, in life-threatening situations, a doctor may prescribe it if the benefits outweigh the risks. Consult your doctor if you are pregnant or planning pregnancy.
Imruza 50 may pass into breast milk and harm the baby. It is probably unsafe to use during breastfeeding. Consult your doctor.
It is not known whether Imruza 50 affects driving ability. Avoid driving if you experience symptoms that affect concentration and reaction.
Use Imruza 50 with caution in patients with kidney disease. Dose adjustment may be necessary. Consult your doctor.
Use Imruza 50 with caution in patients with liver disease. Dose adjustment may be needed. Regular monitoring of liver function tests is advisable. Avoid Imruza 50 in severe liver disease.
Azathioprine
Common side effects of Imruza 50mg Tablet include infections, depression of bone marrow function, leucopenia, thrombocytopenia, nausea, and hypersensitivity reactions. Rare side effects include neoplasms, hepatotoxicity, and immune system disorders.
Imruza 50mg Tablet is used in the management of organ transplantation. It helps the body to accept a transplanted organ like a kidney, liver, heart, lung, or pancreas. It is also useful in some autoimmune diseases including severe inflammatory diseases of the skin, liver, arteries, and blood disorders.
Imruza 50mg Tablet antagonizes purine metabolism, potentially inhibiting the synthesis of DNA, RNA, and proteins. It may also interfere with cellular metabolism and inhibit mitosis. Its mechanism of action is likely due to the incorporation of thiopurine analogs into the DNA structure, causing chain termination and cytotoxicity.
The dosage of Imruza 50mg Tablet varies depending on the condition being treated. For renal homotransplantation, the initial dose is usually 3 to 5 mg/kg daily, adjusted based on individual patient response. For rheumatoid arthritis, the initial dose is approximately 1.0 mg/kg, with adjustments made based on response and tolerance. Maintenance therapy should be at the lowest effective dose.
Imruza 50mg Tablet may interact with various drugs, including allopurinol, neuromuscular blocking agents, anticoagulants, cytostatic/myelosuppressive agents, methotrexate, vaccines, ribavirin, and aminosalicylate derivatives.
Pregnancy:
Mutagenicity & Fertility:
Lactation:
Monitoring for toxic effects is essential throughout the therapy, especially in patients with renal and/or hepatic impairment. Close monitoring of blood counts is necessary, particularly in individuals with a deficiency of thiopurine methyltransferase (TPMT). Caution is advised in patients with Lesch-Nyhan syndrome.