Trifluoperazine is used to manage excessive anxiety, tension, and agitation in neuroses or somatic conditions. It also treats nausea and vomiting of various causes and psychotic disorders like schizophrenia.
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Sizonil 1mg Tablet is prescribed to address schizophrenia, a neurological condition impacting a person's cognition, emotions, and behavior. Symptoms include delusions, hallucinations, apathy, and speech difficulties. Additionally, it's used to manage anxiety, marked by feelings of unease, nervousness, fear, and persistent worry.
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as confusion, dizziness, nausea, vomiting, weakness, fainting, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Sizonil 1 is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Sizonil 1 is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
Use of Sizonil 1 may cause symptoms such as dizziness, blurred vision, confusion, drowsiness, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Sizonil 1 should be used with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening the patient's condition. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Sizonil 1 should be used with extreme caution in patients suffering from liver diseases due to the increased risk of worsening the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Trifluoperazine, the active component of Sizonil 1, blocks dopamine D2 receptors in the brain, exerting weak anticholinergic and sedative effects alongside strong extrapyramidal and antiemetic effects.
Common side effects include restlessness, dystonias, drowsiness, dizziness, and blurred vision. Peripheral edema, blood dyscrasias, and jaundice may rarely occur.
Trifluoperazine, belonging to the phenothiazine class, primarily acts by blocking dopamine receptors in the central nervous system (CNS), which underlies its antipsychotic and antiemetic effects.
For schizophrenia and psychoses, adults typically start with 2-5 mg twice daily, with gradual increases. Children aged 6-12 start with 1 mg twice daily. For severe anxiety, adults may take 1-2 mg twice daily, while children aged 3-12 have adjusted doses based on weight and symptoms. Elderly patients start with reduced doses.
Trifluoperazine may interact with drugs like oral anticoagulants, propranolol, and CNS depressants, altering their effects.
Avoid trifluoperazine in comatose patients, those with blood dyscrasias or liver damage, or hypersensitivity to the drug.
Its safety during pregnancy is not established, so use during pregnancy should be carefully considered. Limited data are available regarding its use during lactation.
Caution is advised when treating elderly patients or those with cardiovascular disease. Careful monitoring for extrapyramidal effects and hypotension is necessary.
Overdose symptoms mainly involve extrapyramidal effects and hypotension. Treatment includes supportive measures and managing symptoms. Anticholinergic drugs can be used for extrapyramidal symptoms, and fluid replacement for hypotension.
Store trifluoperazine at room temperature, away from light and moisture.
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