Clozapine is an atypical antipsychotic drug, distinguishing itself from traditional antipsychotics by its unique interaction with dopamine receptors. It affects dopamine-mediated behaviors differently compared to other typical antipsychotic drugs. Clozapine binds to D1, D2, D3, and D5 dopamine receptors, with a particularly strong affinity for the D4 receptor. This pattern of activity is thought to primarily affect limbic dopamine receptors, which may explain Clozapine’s minimal extrapyramidal side effects. Additionally, Clozapine acts as an antagonist at adrenergic, cholinergic, histaminergic, and serotonergic receptors.
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Treatment of Schizophrenia
Zapenia 100 Tablet works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby helping in improving mood, behavior, and thoughts.
For adults over 16 years: Start with 12.5 mg at bedtime, then increase by 12.5 mg as needed, up to twice weekly. The usual dose is 25-37.5 mg at bedtime, with a maximum daily dose of 50 mg. In exceptional cases, the dose may be further increased to 100 mg daily in 1-2 divided doses.
Common side effects include:
Store below 30°C, away from light, and out of the reach of children.
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