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Type: Tab. Generic Name:Clopidogrel bisulphate INN equivalent to clopidogrel 75mg & aspirin BP 75mg/tablet (f.c) Manufacturer/Distributor: UniHealth
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✅ Description:
Indications of Pladex-A
It is indicated to reduce the rate of Myocardial Infarction (MI) and stroke in patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation Myocardial Infarction (NSTEMI)] and acute ST-segment elevation ACS [ST-elevation Myocardial Infarction (STEMI)].
Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: In patients with established peripheral arterial disease or with a history of recent Myocardial Infarction (MI) or recent Stroke it is indicated to reduce the rate of MI and Stroke.
Pharmaceutical Name
UniMed UniHealth Pharmaceuticals Ltd
Pharmacology
Clopidogrel is a prodrug. It inhibits platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets. Dose-dependent inhibition of platelet aggregation can be seen at 2 hours after single oral doses. Repeated doses of 75 mg per day inhibit ADP-induced platelet aggregation on the first day, and inhibition reaches a steady state between Day 3 and Day 7.
Aspirin inhibits platelet aggregation by irreversible inhibition of platelet cyclooxygenase and thus inhibiting the generation of thromboxane A2 a powerful inducer of platelet aggregation and vasoconstriction.
Dosage & Administration
The recommended oral dose is one tablet daily. Oral anticoagulants, NSAIDs, Metamizole, SSRIs, CYP2C19 inhibitors increase the risk of bleeding. It shows interaction with Tenofovir, Valproic acid, Varicella vaccine, Acetazolamide, and Nicorandil.
Interactions of Pladex-A
Oral anticoagulants, NSAIDs, Metamizole, SSRIs, CYP2C19 inhibitors increase the risk of bleeding. It shows interaction with Tenofovir, Valproic acid, Varicella vaccine, Acetazolamide and Nicorandil.
Contraindications
This combination is contraindicated in the following conditions: Hypersensitivity to the drug substance or any component of the product. Active pathological bleeding such as a peptic ulcer or intracranial hemorrhage.
Side Effects of Pladex-A
This combination is generally well tolerated.
Pregnancy & Lactation
There are no adequate and well-controlled studies in pregnant women. It should be used during first and second trimesters of pregnancy only if clearly needed. It is contraindicated during the third trimester of pregnancy. It is unknown whether Clopidogrel is excreted in human breast milk but Aspirin is known to be excreted in human milk. This Drug should be discontinued during breast feeding.
Precautions & Warnings
This combination may prolong the bleeding time. Thrombotic thrombocytopenic purpura (TTP): TTP has been reported rarely following the use of this combination.Reye's syndrome: Reye's syndrome may develop in individuals who have chickenpox, influenza or flu symptoms. Hypersensitivity including rash, angioedema or hematologic reaction has been reported in patients receiving this combination or history of hypersensitivity to other thienopyridines
Therapeutic Class
Antiplatelet medications
Storage Conditions
Keep in a cool & dry place (below 30o C), protected from light & moisture. Keep out of the reach of children.
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