Rimactazid 300mg

Indications

Antituberculosis agents, such as Rifampicin and Isoniazid, belong to a class of drugs known as antituberculosis drugs. It's a set combination of two highly efficient antituberculosis drugs that inhibit mycobacteria from growing. Tuberculosis is caused by these mycobacteria. Rifampicin and isoniazid are used in the continuation phase of tuberculosis treatment.

Pharmacology

Rifampicin and isoniazid are bactericidal anti-TB medicines that are particularly effective against fast-growing extracellular bacteria and also have intracellular bactericidal activity. In sensitive cells, rifampicin suppresses DNA-dependent RNA polymerase activity. It interacts with bacterial RNA polymerase but has no effect on mammalian RNA polymerase. Only other rifamycins have exhibited cross-resistance to rifampicin. It works against M. tuberculosis, which grows slowly and intermittently. Isoniazid kills tubercle bacilli that are actively developing.

Dosage & Administration

Body weight <50 kg: 3 tablets of 150/100 once daily or 1 tablet of 450/300 once daily

Body weight >50 kg: 2 tablets of 300/150 once daily.

Hepatic impairment: Max: 8 mg/kg daily.

Interaction

May reduce the effectiveness of hormonal contraceptives. Use antacids to reduce absorption. May reduce the plasma concentrations of antiviral drugs (such as atazanavir, darunavir, fosamprenavir), atovaquone and rifampin. Rifampicin can reduce anticonvulsants (such as phenytoin), antiarrhythmic drugs (such as disopyramide), oral anticoagulants, antifungal drugs (such as ketoconazole), barbiturates, β-receptor blockade Serum levels of blockers, Ca channel blockers (such as diltiazem), chloramphenicol, clarithromycin, and corticosporides. , Clofibrate, dapsone, diazepam, doxycycline, fluoroquinolones (such as ciprofloxacin), haloperidol, oral hypoglycemic drugs (sulfonylureas), levothyroxine, Methadone, narcotic pain relievers, progesterone, quinine, tacrolimus line (for example, (for example, theophylline). The use of halothane increases the risk of liver toxicity.

Isoniazid can inhibit the metabolism of anticonvulsants (such as carbamazepine, phenytoin), benzodiazepines (such as diazepam), haloperidol, ketoconazole, theophylline, and warfarin. May enhance the central nervous system effects of pethidine, cycloserine, disulfiram, and isoniazid. Patients taking oral hypoglycemic isoniazid lose blood glucose control.

Contraindications

Known or suspected hypersensitivity to rifamycins and/or to INH, and/or to any of the excipients including a history of drug-induced hepatitis; acute liver diseases, regardless of their origin; peripheral neuritis.

Side Effects

Adverse reactions that may occur during continuous or intermittent daily treatment: Rifampicin: Rifampicin can cause red discoloration of body fluids and occasionally other body secretions (such as urine, sputum, tears, feces, saliva, and sweat). May cause permanent discoloration of soft contact lenses.

Liver effects: Very common (> 10%) is the asymptomatic elevation of liver enzymes; severe life-threatening liver reactions, such as liver failure and acute fulminant hepatitis, are rare (> 0.1% and <1%). In individual cases, (<0.01%), fatal results were observed.

Kidney effects: increased urea nitrogen and blood uric acid, hemolysis, hematuria, interstitial nephritis, renal failure. Gastrointestinal effects: nausea, abdominal pain, vomiting or diarrhea, pseudomembranous colitis.

Effects on the central and peripheral nervous system: fatigue, drowsiness, headache, dizziness, ataxia, confusion, muscle weakness, and visual impairment. Hematologic changes: leukopenia, eosinophilia, thrombocytopenia, and thrombocytopenic purpura. Effects on the skin and accessories: redness, itching, with or without rash, hives, red eyes, exudative conjunctivitis or systemic allergic reactions involving the skin, such as exfoliative dermatitis, Lyle's syndrome, and pemphigoid reaction. Endocrine effects: the menstrual cycle is disturbed, causing a crisis in Addison's patients. Adverse reactions mainly occur during intermittent treatment or when treatment is resumed after a temporary interruption.

Pregnancy & Lactation

Pregnancy Classification C. Although animal reproduction studies have revealed that the medicine has a negative effect on the fetus, and there is no suitable and well-controlled human research, the drug's potential advantages may justify its usage in pregnant women despite the dangers.

Precautions & Warnings

Isoniazid should be used with caution in the following situations:

Alcoholics on a regular basis. Alcohol consumption on a daily basis has been linked to an increased risk of isoniazid hepatitis.

Patients suffering from aggressive chronic liver disease or severe renal failure.

>35 years old.

Use of any chronically administered medicine at the same time.

Isoniazid has previously been discontinued.

Peripheral neuropathy or conditions that predispose to neuropathy are present. Pregnancy.

Use of injectable drugs.

Women from minority groups face unique challenges, particularly in the postpartum period.

Patients who have tested positive for HIV.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.