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Fosfomax 4 Powder For Solution For Infusion
Fosfomax 4 is prescribed for the treatment of the following infections in adults and children, including neonates:
- Osteomyelitis
- Complicated urinary tract infections (UTIs)
- Nosocomial lower respiratory tract infections
- Bacterial meningitis
- Bacteraemia associated with or suspected to be linked to the above infections
Fosfomax is used only when standard antibacterial treatments are deemed inappropriate or ineffective.
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✅ Description:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects:
- Common: Gastrointestinal disturbances, injection site reactions (pain, swelling, redness), hypokalaemia, hypernatraemia
- Rare but Serious: Acute hypersensitivity reactions (e.g., anaphylactic shock), hypotonia, somnolence, thrombocytopenia, hypoprothrombinemia
✔️ Dosage Guidelines: Adults and Adolescents (≥12 years, >40 kg):
- Osteomyelitis: 12–24 g/day in 2–3 divided doses
- Complicated UTIs: 12–16 g/day in 3 divided doses
- Nosocomial lower respiratory tract infections: 12–24 g/day in 2–3 divided doses
- Bacterial meningitis: 16–24 g/day in 3–4 divided doses
Maximum single dose: 8 g
Note: Severe infections caused by resistant bacteria may require higher doses. Doses exceeding 16 g/day require caution due to limited safety data.
✔️ Pediatric Population (<12 years, <40 kg):
- Premature neonates (<40 weeks gestational age): 100 mg/kg/day in 2 divided doses
- Neonates (40–44 weeks): 200 mg/kg/day in 3 divided doses
- Infants (1–12 months, ≤10 kg): 200–300 mg/kg/day in 3 divided doses
- Infants and children (1–12 years, 10–40 kg): 200–400 mg/kg/day in 3–4 divided doses
✔️ Hepatic Impairment:
No dosage adjustment is typically required for patients with liver impairment.
✔️ Renal Impairment:
Adjust dosage based on kidney function. Higher doses should be administered cautiously in patients with impaired renal function.
✔️ Elderly Patients:
The standard adult dosage is appropriate, but higher doses should be used cautiously.
✔️ Administration Instructions:
- Administer via intravenous infusion. For 4 g vials, infusion should last at least 30 minutes.
- Reconstitute with Water for Injections or Glucose Infusion (5% or 10%). Sodium chloride-containing solvents must not be used.
- Shake the vial to loosen the powder, then dissolve 4 g of the drug in 20 ml of solvent.
- Add the reconstituted solution to 80 ml of solvent, resulting in a clear, colorless slightly yellowish infusion solution.
- Use the solution immediately after preparation or store it under refrigeration (2–8°C) for up to 24 hours.
✔️ Duration of Treatment:
The treatment length depends on the type, severity, and clinical response to the infection.
✔️ Overdose Management:
Overdose symptoms may include hypotonia, drowsiness, electrolyte disturbances, thrombocytopenia, and coagulation issues. Symptomatic treatment is recommended.
✔️ Drug Interactions:
No specific drug-drug interaction studies are available for fosfomycin.
✔️ Pregnancy & Lactation
- Pregnancy: Limited clinical data; use only if the benefits outweigh potential risks.
- Breastfeeding: Fosfomycin appears in low concentrations in breast milk; avoid it unless necessary.
✔️ Warnings and Precautions:
- Monitor potassium and sodium levels due to the high sodium load. A low-sodium diet and potassium supplementation may be necessary.
- Use cautiously in patients with cardiac insufficiency, hypertension, hyperaldosteronism, hypernatraemia, or pulmonary edema.
- Discontinue immediately if signs of anaphylactic shock occur.
✔️ Storage:
- Store below 30°C, protected from light and moisture.
- After reconstitution, use immediately or refrigerate (2–8°C) for up to 24 hours.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
